Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Medical Neuroscience


Our department is a center of eye service in Gunma Prefecture and surrounding area, which have 3 million people. We provide medical service for all ophthalmologic disorders with most advanced technology.
Our department is highly reputed in management of vitreoretinal diseases. We have 1400 surgeries in a year and the majority of them are vitreoretinal diseases. Our clinical research is at international level and we are developing newly surgical treatment for various vitreoretinal diseases. Residents have two years training at university hospital. Our education course includes clinical practice under supervisor, a series of lectures and clinical conference (twice a week). Postgraduate school is available after two years residency. Postgraduate school provides two courses including basic research such as molecular biology, physiology and pathology and clinical research of ophthalmology. Doctors outside the university can participate in the postgraduate school at night and week end. After graduation, there are two choices, study in abroad and advanced training in clinical ophthalmology. We accept the international fellowship in program of international federation of ophthalmic society (ICO) / international council of ophthalmology (ICO).

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History


Professor Hideo AKIYAMA, M.D.Ph.D.
Associate Professor Daisuke TODOKORO, M.D.Ph.D.
Associate Professor Hidetaka MATSUMOTO, M.D.Ph.D.
Assiatant Professor Masahiro MORIMOTO
Ryo MUKAI ,M.D.Ph.D.
Satomi NODA

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Research & Education

Research content

Basic research includes: metabolism of vitreous body, experimental ocular neovascularization, genetic analysis of diabetic retinopathy, fine structure of the eye using scanning electron microscopy, microcirculation of the ocular fundus in experimental animals, electrophysiology of the retina.
Clinical research includes: noninvasive observation of retinal tomography using optical coherence tomography in fundus diseases, correlation of morphologic and electrophysiological changes in retinal diseases, clinical and therapeutic aspects of diabetic retinopathy, retinal detachment and age-related macular degeneration. Study of ocular microcirculation using high-speed fluorescein angiography and laser speckle flowgraphy.
Our major target is the fundus disease. We make an effort to find the pathological process and strategies in fundus disease. Many articles have been published from our department in peer-reviewed English journals.

Business education

We introduce the general ophthalmology to the 4th grade students in a series of lectures. We provide the clinical practice for the 5th grade students. A series of lectures for practical ophthalmology is given to the pre-graduate students.
The professor and the associates serve the lectures and practices to the graduate students. Education of basic research is collaborated with laboratories of circulatory disorders, physiology and gene analysis. We give training for ocular microcirculation using fluorescein angiography, laser speckle flowgraphy and scanning laser ophthalmoscope, in vivo histology of the retina using optical coherence tomography and retinal functional study using multifocal electroretinogram. Research achievement is written in English manuscript under our supervision.

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Clinical Activities

We provide outpatient service from Monday to Friday. We have several subspeciality clinics that include: vitreoretinal disease, corneal disease, ocular tumors, diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, glaucoma, macular edema, uveitis, strabismus, low vision and dacryocystitis. We have two days of regular operation in a week and additional operation day twice a month.

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Citizenship Activities

We organize ‘Gunma Ophthalmologic Forum twice a year, where the invited specialist gives a lecture in their subspecialty.
We perform corneal transplantation in cooperation with Gunma Eye Bank and propagate the activity of Eye Bank.
We participate in the visual disability program.
We have co-operation with the group of retinal pigmentary degeneration.
We organize academic meeting for ophthalmologists in Gunma prefecture twice a year. We provide a training course of vitreoretinal practice for doctors from developing countries as a guest institute of ICO/IFOC international fellowship program.

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1. Matsumoto H, Kishi S, Otani T, Sato T: Elongation of photoreceptor outer segment in central serous chorioretinopathy. Am J Ophthalmol 145:162-168, 2008

2. Shimoda Y, Hamano R, Ishihara K, Shimoda N, Hagimura N, Akiyama H, Kishi S, Kaneko A: Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy. Graefes Arch Clin Exp Ophthalmol 246:501-8, 2008

3. Ikeda F, Iida T, Kishi S: Resolution of retinoschisis after vitreous surgery in X-linked retinoschisis. Ophthalmology 115:718-722, 2008

4. Li D, Kishi S: Loss of photoreceptor outer segment in acute zonal occult outer retinopathy. Arch Ophthalmol 125:1194-200, 2007

5. Sato T, Kishi S, Watanabe G, Matsumoto H, Mukai R: Tomographic features of branching vascular networks in polypoidal choroidal vasculopathy. Retina 27:589-94, 2007

6. Yamaguchi Y, Otani T, Kishi S: Tomographic features of serous retinal detachment with multilobular dye pooling in acute Vogt-Koyanagi-Harada disease. Am J Ophthalmol 144: 260-5, 2007

7. Yoshida M, Kishi S: Pathogenesis of macular hole recurrence and its prevention by internal limiting membrane peeling. Retina 27: 169-73, 2007

8. Otani T, Kishi S: Correlation between optical coherence tomography and fluorescein angiography findings in diabetic macular edema. Ophthalmology 114: 104-7, 2007

9. Takahashi K, Kishi S: Serous macular detachment associated with retinal arterial macroaneurysm. Jpn J Ophthalmol 50: 460-4, 2006

10. Takahashi K, Kashima T, Kishi S: Massive macular hard exudates associated with branch retinal vein occlusion. Jpn J Ophthalmol 49: 527-9, 2005

11. Itakura, H., Kishi, S., Kotajima, N., Murakami, M: Vitreous collagen metabolism before and after vitrectomy. Graefe’s Archive for Clinical and Experimental Ophthalmology 243:994-998, 2005

12. Yamada, N., Kishi, S: Tomographic features and surgical outcomes of vitreomacular traction syndrome. American Journal of Ophthalmology 139: 112-117, 2005

13. Utsugi, N., Takahashi, K., Kishi, S: Choroidal vascular occlusion in internal carotid artery obstruction. Retina 24: 915-919, 2004

14. Sato, T., Iida, T., Hagimura, N., Kishi, S: Correlation of optical coherence tomography with angiography in retinal pigment epithelial detachment associated with age-related macular degeneration. Retina 24: 910-914, 2004

15. Otani, T., Yamaguchi, Y., Kishi, S: Serous macular detachment secondary to distant retinal vascular disorders. Retina 24: 758-762, 2004

16. Li, D., Horiguchi, M., Kishi, S: Tomographic and multifocal electroretinographic features of idiopathic epimacular membranes. Archives of Ophthalmology 122: 1462-1467, 2004

17. Itakura, H., Kishi, S., Kotajima, N., Murakami, M: Persistent secretion of vascular endothelial growth factor into the vitreous cavity in proliferative diabetic retinopathy after vitrectomy. Ophthalmology 111: 1880-1884, 2004

18. Maeshima, K., Utsugi-Sutoh, N., Otani, T., Kishi, S: Progressive enlargement of scattered photocoagulation scars in diabetic retinopathy. Retina 24: 507-511, 2004

19. Maruyama, Y., Kishi, S: Tomographic Features of Serous Retinal Detachment in Vogt-Koyanagi-Harada Syndrome. Ophthalmic Surgery Lasers and Imaging 35: 239-242, 2004

20. Akiyama, H., Tanaka, T., Itakura, H., Kanai, H., Maeno, T., Doi, H., Yamazaki, M., (…), Kurabayashi, M: Inhibition of ocular angiogenesis by an adenovirus carrying the human von Hippel-Lindau tumor-suppressor gene in vivo. Investigative Ophthalmology and Visual Science 45: 1289-1296, 2004


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Maebashi medical special school was established in 1943. The first president was Dr. Shinobu Ishihara who is ophthalmologist well known as Ishihara’s color blindness chart. The 1st Professor in our department was Dr. Shimizu Okamura (1943-44).
The 2nd Professor was Dr. Heihachi Aoki (1946-72). The main themes of department were anterior segment disorders and retinal pigment degeneration in the period.
The 3rd Professor was Dr. Koichi Shimizu (1972-98). After he introduced fluorescein angiography and laser photocoagulation, our department took a leading position in diagnosis and treatment of fundus disease at the international level.
The 4th Professor is Dr. Shoji Kishi (1998- ). We can recognize the fundus disease as a three dimension by his discovery of precortical vitreous pocket. We clarified the pathologic process of macular hole, diabetic retinopathy, macular edema and high myopia that resulted in highly successful vitreoretinal surgery. We are developing clinical research in ocular microcirculation, in vivo histology as well as newly treatment for retinal diseases. Recently we are applying molecular biology in ophthalmology