Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Medical Neuroscience


Neurological sciences are not only exploring an exciting and mysterious world of human brain but also fighting against neurodegenerative disorders most prevalent in increasing population of the aged. Since the beginning of our department, we have been focusing on clinical and basic researches of amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease and cerebrovascular disorders. Cell biological and molecular genetic researches as well as clinical practices and researches aided by the advanced techniques and equipments in University Hospital are further developing with fruitful results. Our department also devotes its energies to the education of the neurological sciences to bring up excellent clinicians and researchers.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History


Professor IKEDA Yoshio, M.D., D.M.Sci.
Associate Professor IKEDA Masaki, M.D., D.M.Sci.
Associate Professor FUJITA Yukio, M.D., D.M.Sci.
NAGASHIMA Kazuaki, M.D., D.M.Sci.
Assistant Professor MAKIOKA Koki,M,D.
FURUTA Natsumi,M,D.

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Research & Education

Research content

#1 Genomic analysis on hereditary neurological disorders
#2 Cell biological and molecular genetic approaches to Alzheimer’s disease
#3 Molecular biology and pathology in amyotrophic lateral sclerosis

Business education

#1 Education in School of Medicine
A course of lectures on diagnostic, clinical and therapeutic neurology
A course of bedside teaching
#2 Education in Graduate School of Medicine
For 4-year PhD (DMSci) course, options in our research excellence are offered.
#3 Postgraduate Clinical Training Program in University Hospital
Our hospital is an authorized medical training facility for registered physicians or neurologists.

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Clinical Activities

Clinical practice in University Hospital
Neuroimaging (PET, SPECT, MRI and CT)
Electrophysiological and pathological diagnosis
Gene diagnosis of hereditary neurological disorders
as an authorized highly-advanced medical technology
Development of new pharmaceuticals and clinical trials

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Citizenship Activities

Social action program as Medical Center supporting and contributing to
Medical cooperation with office-based physicians
Gunma clinical network of obstinate neurological diseases
Regional network for early diagnosis and treatment of dementing disorders

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1)Harigaya Y, Matsukawa T, Fujita Y, Mizushima K, Ishiura H, Mitsui J, Morishita S, Shoji M, Ikeda Y, Tsuji S. Novel GBE1 mutation in a Japanese family with adult polyglucosan body disease. Neurol Genet. 2017; 3: e138.

2)Hirayanagi K, Ikeda Y. Response to the letter to the editor regarding an article “Bilateral striatal necrosis caused by a founder mitochondrial 14459G>A mutation in two independent Japanese families”. J Neurol Sci. 2017; 380: 283-284.

3)Hirayanagi K, Okamoto Y, Takai E, Ishizawa K, Makioka K, Fujita Y, Kaneko Y, Tanaka M, Takashima H, Ikeda Y. Bilateral striatal necrosis caused by a founder mitochondrial 14459G>A mutation in two independent Japanese families. J Neurol Sci. 2017; 378: 177-181.

4)Iwama K, Mizuguchi T, Takanashi JI, Shibayama H, Shichiji M, Ito S, Oguni H, Yamamoto T, Sekine A, Nagamine S, Ikeda Y, Nishida H, Kumada S, Yoshida T, Awaya T, Tanaka R, Chikuchi R, Niwa H, Oka YI, Miyatake S, Nakashima M, Takata A, Miyake N, Ito S, Saitsu H, Matsumoto N. Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts. Clin Genet. 2017; 92: 180-187.

5)Nagashima K, Furuta N, Makioka K, Fujita Y, Ikeda M, Ikeda Y. An analysis of prognostic factors after percutaneous endoscopic gastrostomy placement in Japanese patients with amyotrophic lateral sclerosis. J Neurol Sci. 2017; 376: 202-205.

6)Tsukagoshi S, Ishizawa K, Hirayanagi K, Nagamine S, Makioka K, Fujita Y, Ikeda Y. Progressive Pseudolithiasis Associated with the Intravenous Administration of Ceftriaxone in Patients with Central Nervous System Infections. Intern Med. 2017; 56: 3189-3192.

7)Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H. Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome. Sci Rep. 2018; 8: 819.

8)Yamazaki Y, Suzuki A, Hirayanagi K, Tsukagoshi Y, Uehara R, Horiguchi K, Ohyama T, Tomaru T, Horiguchi N, Nobusawa S, Ikota H, Sato K, Kakizaki S, Kusano M, Ikeda Y, Yokoo H, Yamada M. An Autopsy Case of Fulminant Hepatitis in a Patient with Multiple Sclerosis Treated by Interferon-Beta-1a. Intern Med. 2017; 56: 1897-1901.

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Clinical neurology in Gunma University started with the establishment of the Neurological Division in the Institute of Neurology and Rehabilitation in School of Medicine in 1973, and Dr Shunsaku Hirai was invited as the first professor. Division of Neurology in University Hospital began to operate in 1975.
Professor Koichi Okamoto took over in 1996, and reorganized the Neurological Division into Department of Neurology School of Medicine in 1999. In 2003, Department of Neurology was advanced to a part of Gunma University Graduate School of Medicine.