Division of Breast and Endocrine Surgery
Breast and Endocrine Surgery
Breast cancer is the highest incidence disease among female malignant neoplasm. We review diagnosis and treatment of breast cancer and endocrine disorders. Basic research includes 1) mechanism of therapy resistance in breast cancer, 2) tumor angiogenesis, 3) biomarker of sensitivity for breast cancer treatment, 4) an exhaustive analysis of breast cancer prognostic factors, including micro RNA and tumor infiltrating lymophocytes (TILs). In addition, clinical study includes 1) additional usefulness of FDG-PET in breast cancer, 2) Mechanism of lymph node metastasis, 3) analysis of navigation surgery for identification of parathyroid glands and sentinel lymph nodes.
It is not necessary to focus on the specific research subject, which you belong to. We held a research conference every week and discuss everything to solve the research problems with our professor.
|Director and Chief：
|Takaaki Fujii, MD, PhD, FACS|
|Staff||Tomoko Hirakata, MD, PhD|
|Reina Yajima, MD, PhD|
|Sayaka Obayashi, MD, PhD|
|Sasagu Kurozumi, MD, PhD|
|Yuko Nakazawa, MD|
|Shoko Tokuda, MD|
|Keiko Yanai, MD|
(Medical Education Center)
|Mami KIKUCHI, MD, PhD|
Research & Education
1. Mechanism of therapy resistance in breast cancer, 2. Tumor angiogenesis, 3. Biomarker of sensitivity for breast cancer treatment, 4. An exhaustive analysis of breast cancer prognostic factors, including micro RNA and TILs, 5. Additional usefulness of FDG-PET in breast cancer, 6. Mechanism of lymph node metastasis, 7. Analysis of navigation surgery for identification of parathyroid glands and sentinel lymph nodes.
We try to work on streamlining surgical training and foreshortening training period. You may be able to start your graduate course as soon as you reach for minimum admission requirement.
With increasing emphasis on the cosmetic outcome of breast surgery, the role of immediate breast reconstruction has become important. We have performed nipple-sparing mastectomy with immediate breast reconstruction using tissue expander since 2002. We also use minimally invasive surgical techniques, including minimally invasive parathyroidectomy and thyroidectomy. We recently demonstrated that in scan-positive patients identified by Tc-MIBI, Tc-MIBI scintigraphy with the use of a hand-held gamma camera, is useful for navigation surgery for PHPT and minimally invasive parathyroidectomies.
Fujii T, et al. Phase II Study of S-1 plus Trastuzumab for HER2-positive Metastatic Breast Cancer (GBCCSG-01). Anticancer Res (in press)
Fujii T, et al. Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Relationship between brown adipose tissue and breast cancer progression. Oncology Letters (in press)
Obayashi S, et al. Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients. Int J Oncol 2017
Kurozumi S, et al. Significance of evaluating tumor-infiltrating lymphocytes (TILs) and programmed cell death-ligand 1 (PD-L1) expression in breast cancer. Med Mol Morphol 2017
Kurozumi S, et al. Power of PgR expression as a prognostic factor for ER-positive/HER2-negatiev breast cancer patients at intermediate risk classified by the Ki67 labeling index. BMC Cancer 2017.
Kurozumi S, et al. Recent in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes. J Hum Genet 2017.
Fujii T, et al. Clinicopathological Features of Ductal Carcinoma In Situ from 18F-FDG-PET Findings. Anticancer Res 2017.
Fujii T, et al. 18F-fluorodeoxyglucose uptake as predictor for invasion in preoperatively diagnosed breast ductal carcinoma in situ: Significance in cases without mass formation
Mol Clin Oncol 2017
Fujii T, et al. A case of subareolar abscess in the male breast: Usefulness of MRI for diagnosis. International Journal of Case Reports and Images 2017
Yajima R, et al. Tumor-infiltrating CD45RO+ memory cells are associated with a favorable prognosis
breast cancer. Breast Cancer 2016.
Kurozumi S, et al. HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients. Breast Cancer Res Treat 2016.
Kurozumi S, et al. Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer. Cancer Med 2016.
Fujii T, et al. Clinicopathological features of cases with primary breast cancer not identified by 18F-FDG-PET. Anticancer Res 2016.
Fujii T, et al. Clincal significance of 18F-FDG-PET in invasive lobular carcinoma. Anticancer Res 2016.
Fujii T, et al. Implication of F18-fluorodeoxyglucose uptake of affected axillary lymph nodes in cases with differentiated thyroid cancer. Mol Clin Oncol 2016.
Fujii T, et al. Implications of long-term indwelling of tissue expander in breast reconstruction: risk of expander rupturing. Anticancer Res 2016.
Fujii T, et al. Implication of F18-fluorodeoxyglucose uptake of affected axillary lymph nodes in cases with breast cancer. Anticancer Res 2016.
Fujii T, et al. Prediction of extracapsular invasion at metastatic sentinel nodes and non-sentinel lymph nodal metastases by FDG-PET in cases with breast cancer. Anticancer Res 2016
Fujii T, et al. Anticancer effect of rapamycin on MCF-7 via downregulation of VEGF expression. In Vitro Cell Dev Biol Anim 2016.
Fujii T, et al. Cystic parathyroid adenoma with MIBI scan-negative PHPT: Usefulness of Gamma camera. Int J Case Rep Imag 2016.
Kurozumi S, et al. ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab. BMC Cancer 2015.
Fujii T, et al. Impact of vascular invasion of a primary tumor as a strong risk factor for disease recurrence in patients with node-positive breast cancer. Am Surg 2015
Fujii T, et al. Significance of lymphatic invasion combined with size of primary tumor for predicting sentinel lymph node metastasis in patients with breast cancer. Anticancer Res 2015
Fujii T, et al. Implication of duration of clinical presentation on tumor progression and the short-term recurrence in patients with early breast cancer. Mol Clin Oncol 2015
Yajima R, et al. Prognostic value of extracapsular invasion of axillary lymph nodes combined with peritumoral vascular invasion in patients with breast cancer. Ann Surg Oncol 2015.