Graduate School of Medicine / School of Medicine, Faculty of Medicine

  • Campus Map
  • Site Map
  • Contact us
  • Japanese
  • English

Injection & Bioresponse


Our activities include dermatological treatment, education and research.  We always keep it in our mind that ” the result of research and education should be given back to practical field”, and we carry out our research in order to resolve problems caused from clinician’s perspective.  Our education policy is fostering not only specialists of dermatology but also general physicians who never overlook any common skin diseases.  In particular, the leaders specializing rheumatology, immunology, oncology or skin surgery conduct researches as well as clinical practice such as diagnosis and therapy of patients.
Clinical conferences and research sessions are regularly held.  Subgroups hold small conferences, research meetings and journal seminars.  Each doctor actively attends dermatological conferences.  There are a lot of opportunities for studying at overseas or domestic institutes.  We always make the greatest effort to maintain high standard of expertise.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History


Professor Osamu ISHIKAWA, M.D., Ph.D.
Associate Professor Sei-ichiro MOTEGI, M.D., Ph.D.
Associate Professor Akira SHIMIZU, M.D., Ph.D.
Masahito YASUDA, M.D., Ph.D.
Chikako KISHI, M.D., Ph.D.
Assistant Professors Yukie ENDO, M.D., Ph.D.
Akihito UEHARA, M.D., Ph.D.
Sayaka TOKI
Mariko SUDO

Top of Page

Research & Education

Research content

1)Role of hypoxia-inducible factor (HIF) in systemic sclerosis

2)Role of connective tissue growth factor (CTGF) in systemic sclerosis

3)Intracellular signal transduction and changes of cytoskelton in cutaneous wound healing

4)Role of sphingolipids in the regulation of extracellular matrix

5)Effect of phychological stress on atopic dermatitis model mice

6)Investigation of innate immunity in atopic dermatitis

7)Generation of scleroderma model mice and analysis of the mechanism of fibrosis

8)Evaluation of micrometastases of skin cancers using RT-PCR

9)Genetic analyses of heritable skin diseases and skin tumors

10)Investigation of collagen disease and viral infection

11)Investigation of skin tumors and viral infection

12)The regulation of angiogenesis in malignant melanoma

13)Invetigation of peripheral circulatory disturbance in systemic sclerosis

14)Epigenetic analysis in the pathogenesis of systemic sclerosis

15)Analysis of the roles of bioactive lipids in skin

Business education

1)Lecture on dermatology to college students

2)Clinical practice for college students

3)Instruction of writing to college and graduate students

4)Lecture on dermatology to graduate students

5)Instruction of dermatological research to graduate students

6)Seminar on dermatology (for medical doctors)

7)Workshop on dermatological research (for graduate students)

8)Seminar on clinical dermatology (for junior doctors and students) doctors

Top of Page

Clinical Activities

1)Autoimmune rheumatic diseases (systemic sclerosis, systemic lupus erythematosus, cutaneous lupus erythematosus and dermatomyositis)
2)Atopic dermatitis
3)Malignant skin tumors
4)Skin surgery and laser surgery
5)Bullous skin disease
6)Refractory skin ulcer
7)Infectious diseases
8)Psoriasis vulgaris

Top of Page

Citizenship Activities

1)Physical checkup for skin cancer
2)Complimentary consultation for skin diseases
3)Public lecture on skin diseases
4)Workshop for patients with psoriasis vulgaris
5)Enlightenment for skin diseases
6)Special lecture for patients

Top of Page


1)Motegi S-I, Sekiguchi A, Uehara A, Ishikawa O. Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress. Sci Rep, 2017 Dec 7;7(1):17186. doi: 10.1038/s41598-017-17630-5

2)Uchiyama A, Ishikawa O, Motegi S-I. Mesenchymal stem cells-derived MFG-E8 accelerates diabetic cutaneous wound healing. J Dermatol Sci, 86(3):187-197, 2017

3)Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H.. RXRB is a MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis. J Invest Dermatol, 86(3): 187-197, 2017

4)Motegi SI, Uehara A, Yamada K, Sekiguchi A, Fujiwara C, Toki S, Date Y, Nakamura T, Ishikawa O. Efficacy of Botulinum toxin B injection for Raynaud’s phenomenon and digital ulcers in patients with systemic sclerosis. Acta-Dermato-Venereologica. 97(7): 843-850, 2017

5)Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cernic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelman N, Baron M, Hassouns P, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Trans-ethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis 76(6): 1150-1158, 2017

6)Yanagita T, Murata Y, Tanaka D, MotegiS-I, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg P-A, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. 2017; 2(1):e89140. doi:10.1172/jci. insight.89140.

7)Kishi C, Ishikawa O, Motegi S-I. Elevated serum MFG-E8 level is possibly associated with the presence of high-intensity cerebral lesions on magnetic resonance imaging in patients with systemic lupus erythematosus. J Dermatol. 44(7): 783-788, 2017

8)Motegi SI, Ishikawa O. Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth. J Dermatol Sci. 86(2): 83-89, 2017

9)Shimizu A, Kaira K, Okubo Y, Utsumi D, Yasuda M, Asao T, Tominaga H, Oriuchi N, Kanai Y, Takahashi K, Ishikawa O. Prognostic impact of LAT1 and CD98 expression in cutaneous angiosarcoma. Neoplasma, 64(2): 283-288, 2017

10)Motegi SI, Sekiguchi A, Fujiwara C, Toki S, Ishikawa O. Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis. J Dermatol, 44(2): 167-172, 2017

11)Shimizu A, Kaira K, Yasuda M, Asao T, Ishikawa O. Clinical and pathological significance of ER stress marker (Bip/GRP78 and PERK) expression in malignant melanoma. Pathol Oncol Res, 23(1):111-116, 2017

12)Hattori M, Shimizu A, Ishikawa O. Alopecia areata associated with Graves’ disease. Kitakanto Medical Journal , 67:169-171, 2017

13)Motegi SI, Yasuda M, Yamanaka M, Amano H, Ishikawa O. Cutaneous collagenous vasculopathy: Report of first Japanese case and review of the literature. Australas J Dermatol. 58(2):145-149, 2017

14)Hattori M, Shimizu A, Tsukagoshi H, Saruki N, Kaira K, Ohkawa T, Ishikawa O. A mild phenotype of hand, foot and mouth disease caused by Coxsackievirus A6. Eur J Dermatol. 27(5):527-528, 2017

15)Uchiyama A, Motegi S-I, Fujiwara C, Sekiguchi A, Yasuda M, Amano H, Ishikawa O. Trigeminal trophic syndrome; Analysis of the number of peripheral nerve fibers and blood vessels in the lesional skin. Austral J Dermatol , 59(1):59-61, 2018

16)Fujiwara C, Motegi S-I, Sekiguchi A, Amano H, Ishikawa O. Pyogenic granuloma possibly associated with capecitabine therapy. J Dermatol , 44(4):473-474, 2017

17)Motegi S-I, Sekiguchi A, Toki S, Amano H, Ishikawa O. Progressive myelopathy in systemic sclerosis patient with cervical intraspinal calcinosis. J Dermatol. 44(2) :209-2010, 2017

18)Hattori M, Shimizu A, Kaira K, Ishikawa O. Atypical flat wart in an immunocompromised host. J Dermatol. 44(4): 473-474, 2017

19)Yamada K, Uchiyama A, Uehara A, Perera B, Ogino S, Yokoyama Y, Takeuchi Y, Udey MC, Ishikawa O, Motegi S-I. MFG-E8 drives melanoma growth by stimulating mesenchymal stromal cell-induced angiogenesis and M2 polarization of tumor-associated macrophages. Cancer Res. May 17. pii: canres.2812.2015. [Epub ahead of print], 2016

20)Uchiyama A, Yamada K, Perera Buddhini, Ogino S, Yokoyama Y, Takeuchi Y, Ishikawa O, Motegi, S-I . Topical betamethasone butyrate propionate exacerbates pressure ulcers after cutaneous ischemia-reperfusion injury. Exp Dermatol , Apr 20. doi: 10.1111/exd.13043. [Epub ahead of print], 2016

21)Yasuda M, Yamaguchi S, Miyachi Y, Ishikawa O, Takahashi K. Palmoplantar collagen bundle size correlated with a characteristic spatial expression of decorin and lumican. Exp Dermatol, 25(4); 318-20, 2016

22)Shimizu A, Kaira K, Yasuda M, Asao T, Ishikawa O. Decreased expression of class III β-tubulin is associated with unfavourable prognosis in patients with malignant melanoma.Melanoma Res. 26(1):29-34, 2016

23)Motegi S-I, Yamada K, Toki S, Uchiyama A, Kubota Y, Nakamura T, Ishikawa O. Beneficial effect of botulinum toxin A on Raynaud’s phenomenone in Japanese patients with systemic sclerosis: a prospective, open-label trial. J Dermatol . 43(1):56-62, 2016

24)Hattori M, Yokoyama Y, Hattori T, Motegi S-I, Amano H, Hatada I, Ishikawa O. Global DNA hypomethylation and hypoxia-induced expression of the ten eleven translocation (TET) family, TET1, in scleroderma fibroblasts. Exp Dermatol 24:841-846, 2015

25)Motegi S-I, Uchiyama A, Yamada K, Perera B, Ogino S, Yokoyama Y, Takeuchi Y, Ishikawa O. Pathogenesis of Multiple Lentigines in LEOPARD Syndrome with PTPN11 Gene Mutation. Acta Derm Venereol. 95(8):978-984, 2015

26)Shimizu A, Kaira K, Kato M, Yasuda M, Takahashi T, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Asao T, Ishikawa O. Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma. Melanoma Res 25(5):399-405, 2015

27)Uchiyama A, Yamada K, Perera B, Ogino S, Yokoyama Y, Takeuchi Y, Ishikawa O, Motegi S-I. Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury. Sci Rep Mar 13; 5: 9072., 2015

28)Kato M, Shimizu A, Yamamoto A, Shimomura Y, Ishikawa O. A novel autosomal recessive mutation of DSG4 causes monilethrix through the ER stress response. J Invest Dermatol 135(5):1253-1260, 2015 (平成26年度群馬大学大学院最優秀賞)

29)Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Udey MC, Ishikawa O, Motegi S-I. Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury. J Invest Dermatol 135(4):1157-65, 2015

30)Motegi S-I, Toki S, Yamada K, Uchiyama A, Ishikawa O. Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies. J Dermatol 42(2): 189-192, 2015

31)Yasuda M, Kishi C, Yokoyama Y, Amano H, Ishikawa O. A case of X-linked hypohidrotic ectodermal dysplasia with a novel EDA missense mutation. J Dermatol 42(9):907-908, 2015

32)Shimizu A, Kato M, Takeuchi Y, Sano T, Uezato H, Ishikawa O. Detection of human papilloma virus in patients with squamous cell carcinoma and the clinical characteristics of HPV-positive cases. Br J Dermatol 171(4): 779-785, 2014

33)Motegi S-I, Okada E, Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Monma F, Suzuki T, Ishikawa O. Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis. Exp Dermatol 23(9): 664-669, 2014

34)Kishi C, Amano H, Suzue K, Ishikawa O. Plasmodium berghei infection ameliorates atopic dermatitis-like skin lesions in NC/Nga mice. Allergy 69(10): 1412-1419, 2014

35)Shimizu A, Nakatani Y, Nakamura T, Jinno-Oue A, Ishikawa O, Boeke JD, Takeuchi Y, Hoshino H. Characterization of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells. Sci Rep 4: 5074, 2014

36)Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Udey MC, Ishikawa O, Motegi S-I. MFG-E8 regulates angiogenesis in cutaneous wound healing. Am J Pathol 184(7): 1981-1990, 2014

37)Kato M, Shimizu A, Takeuchi Y, Hattori T, Abe M, Amano H, Motegi S-I, Tamura A, Ishikawa O. Human papillomaviruses in anogenital epithelial lesions. Acta Derm Venereol 94(5): 597-599, 2014

38)Hattori T, Takeuchi Y, Takenouchi T, Hirofuji A, Tsuchida T, Kabumoto T, Fujiwara H, Ito M, Shimizu A, Okada E, Motegi S-I, Tamura A, Ishikawa O. The prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinoma. J Dermatol Sci 70(2): 99-107, 2013

Top of Page


Our department was launched when Prof. Jun Yamazaki (Tokyo University) was welcomed to Gunma University as the first chairman in 1944. Then, Prof. Hidekazu Ishikawa (Tokyo University), as the second chairman in 1972, made clinical practice and research on systemic sclerosis as his lifework. The fundamentals of clinical practice and research for collagen diseases were established during this period. In 1992, Prof. Yoshiki Miyachi (Kyoto University) became the third chairman. He had made great contribution to promote clinical practice and research for skin allergology and skin surgery, in addition to collagen diseases practice and research. The present Prof. Osamu Ishikawa was promoted to the fourth chairman in 1999. Since then, we have actively absorbed new scientific knowledge and technology in the field of cell biology molecular biology. Now, our research activities have covered wound healing, skin allergology, skin oncology and skin surgery as well as autoimmune rheumatic diseases.
One young dermatologist has been studying abroad in United States.
Recently, pressure ulcer is one of the severe problems among aging society. We actively spread out the research and clinical practice in the field of wound healing.Proffessor Ishikawa is widening his activities as the director of Gunma University Hospital four years since 2007, and vice-president (education and international exchenge) of Gunma University since 2011.