Injection & Bioresponse
Pediatricians are a “general physician” who manage various diseases from the fetus to the AYA generation. Furthermore, they are also involved in the field of child health, which has become a major social problem such as child abuse. It is an important role for us not only to cure children with mental and physical problems, but also to care and manage the development of healthy children.
Our department consist of 10 clinical groups and 5 research ones. To aim new strategies for treatment and improvement of QOL with affected children, we always continue to make efforts in the field, from genetic analysis to field work. There is a special education course for medical students. Also, we have some training courses for postgraduate doctors. We all guide younger doctors to get evidence based-medicine and communication skills.
|Professor||ARAKAWA Hirokazu, M.D., Ph.D.|
|Associate Professor||TAKIZAWA Takumi, M.D., Ph.D.|
|Associate Professor||FUJIU Toru, M.D.,Ph.D.|
|KOBAYASHI Yasuko, M.D.,Ph.D.|
|Assistant Professor||IKEUCHI Yuka, M.D.,Ph.D.|
|OKUNO Haruna, M.D.|
|INOUE Takahiro, M.D.|
|OHTSU Yoshiaki, M.D., Ph.D.|
|HORIKOSHI Takanobu, M.D.|
|TAKAGI Youko, M.D.|
|HARA Yusuke, M.D., Ph.D.|
|KAWASHIMA Jun, M.D.|
Research & Education
Mechanism of GLP-1 secretion promoting through sweet receptor
Establishment of a method for differential diagnosis of idiopathic nephrotic syndrome by podocyte cell biology
Comprehensive analysis of 343 genes in pediatric acute myeloid leukemia using next-generation sequencers
Elucidation of developmental prognosis in congenital central hypoventilation syndrome
Estimation of the prevalence, antibiotic susceptibility, and risk factors for E. coli colonization at birth in premature infants
Functional analysis of novel genes targeting very early-onset inflammatory bowel disease
Mechanism of mucin production from airway epithelial cells in the chronic airway diseases
Education for Students
1) Third year：
Lectures on “Growth and Development of human”
2) Fourth Year：
Lectures on “Diseases of Children”, and class examination.
Tutorial teaching will begin from 2005.
3) Fifth Year: as MDC
Bedside instruction (2 weeks).
4) Six Year: Optional practice in Pediatric ward,
Clinical practice at bedside with resident doctor for 2 weeks, and graduation examination.
As a tertiary referral center, our Department of Pediatrics provides the highest level of pediatric care. The Department also manages critically ill newborns suffering from a wide variety of diseases in the Neonatal Intensive Care Unit. Thus, our range of services includes treating premature infants, full-term newborns, toddlers, youth, adolescents, and all ages and life stages in between. There are several subspecialty services within the Department; allergy, pulmonology, endocrinology, gastroenterology, genetics and metabolism, hematology, oncology, immunology, nephrology, neurology, child psychiatry, and cardiology. This allows us to have skilled multi-disciplinary teams that work well together to deal with almost any disease or disorder a child may have.
1. Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita A, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y. Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome. Genes Chromosomes Cancer. 56(5): 394-404. 2017
2. Hatori R. Tomomasa T, Ishige T, Tatsuki M, Arakawa H. Fecal retention in childhood: Evaluation.on ultrasonography. Pediatr Int. 59(4): 462-466. 2017
3. Hazama K. Shiihara T, Tsukagoshi H, Hasegawa S,Dowa Y, Watanabe M. A case of mumps-related acute encephalopathy with biphasic seizures and late reduced diffusion. Brain & Development. 39(9): 808-810. 2017
4. Ishige T. Tomomasa T, Hatori R, Tatsuki M, Igarashi Y, Sekine K, Arakawa H. Temporal Trend of Pediatric Inflammatory Bowel Disease: Analysis of National Registry Data 2004 to 2013 in Japan. J Pediatr Gastroenterol Nutr. 65(4): e80-e82. 2017
5. Ichinomiya K. Maruyama K, Inoue T, Koizumi A, Inoue F, Fukuda K, Yamazaki Y, Arakawa H. Perinatal Factors Affecting Serum Hepcidin Levels in Low-Birth-Weight Infants. Neonatology. 112(2): 180-186. 2017
6. Kamata A, Muramatsu K, Sawaura N, Makioka N, Ogata T, Kuwashima M, Arakawa H. Demyelinating Demyelinating neuropathy in a 6-year-old girl with autism spectrum disorder. Pediatr Int. 59(8): 951-954. 2017
7. Kobayashi Y. Aizawa A, Takizawa T, Igarashi K, Hatada I and Arakawa H. Changes in DNA methylation in naïve T helper cells regulate the pathophysiological state in minimal-change nephrotic syndrome. BMC Research Notes. 10(1): 480. 2017
8. Muramatsu K, Sawaura N, Ogata T, Makioka N, Tomita K, Motojima T, Ida K, Hazama K, Arakawa H. Efficacy and tolerability of levetiracetam for pediatric refractory epilepsy. Brain Dev. 39(3): 231-235. 2017
9. Oyanagi T, Takizawa T, Aizawa A,Solongo O, Yagi H, Nishida Y, Koyama H, Saitoh A, Arakawa H. Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ . Allergol Int. 66(1): 75-82. 2017
10. Yamato G, Shiba N, Yoshida K, Shiraishi Y, Hara Y, Ohki K, Okubo J, Okuno H, Chiba K, Tanaka H, Kinoshita A, Moritake H, Kiyokawa N, Tomizawa D, Park MJ, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Miyano S, Ogawa S, Hayashi Y. ASXL2 mutations are frequently found in pediatric AML patients with t(8;21)/ RUNX1-RUNX1T1 and associated with a better prognosis. Genes Chromosomes Cancer. 56(5): 382-393. 2017
11. Yamato G, Yamaguchi H, Handa H, Shiba N, Kawamura M, Wakita S, Inokuchi K, Hara Y, Ohki K, Okubo J, Park MJ, Sotomatsu M, Arakawa H, Hayashi Y. Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia. Genes Chromosomes Cancer. 56(11): 800-809. 2017
12. Arakawa N, Takizawa T, Nishida Y, Yagi H, Arakawa H. Chronic recurrent ostemyelitis with systemic juvenile idiopathic arthritis. Kitakanto Med J. 68(3): 167-169. 2018;
13. Hamajima E, Noda M, Nai E, Akiyama S, Ikuta Y, Obana N, Kawaguchi T, Hayashi K, Oba K, Yoshida T, Katori T, Kokaji M. Therapy with propylthiouracil for T3-predominant neonatal Graves’ disease: A case report. Clin Pediatr Endocrinol. 27(3): 165-169. 2018
14. Ichinomiya K, Maruyama K, Koizumi A, Inoue F, Fukuda K, Kaburagi K, Miyakawa Y; Neonatal Research Network of Japan. Comparison of neurodevelopmental outcomes between monochorionic and dichorionic twins with birth weight ≤ 1500 g in Japan: a register-based cohort study. J Perinatol. 38(10): 1407-1413. 2018
15. Ishige T, Igarashi Y, Hatori R, Tatsuki M, Sasahara Y, Takizawa T, Arakawa H. IL-10RA Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report. Pediatrics. 141(6): pii: e20173548. 2018
16. Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T. Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes. Mol Biol Cell. 29(2): 202-219. 2018
17. Ito K, Takizawa T. Nuclear Architecture in the Nervous System: Development, Function, and Neurodevelopmental Diseases. Front Genet. 9: 308. 2018
18. Motojima T, Fujii K, Ohashi H, Arakawa H. Catathrenia in Pitt-Hopkins syndrome associated with 18q interstitial deletion. Pediatr Int. 60(5): 479-481. 2018
19. Nishizawa T, Ohki Y, Urano H Suzuki T, Kuwashima M. Knotted transpyloric tube in an infant, a patient report. Pediatr Int. 60(3): 310-133. 2018
20. Wada A, Muramatsu K, Sunaga Y, Mizuno T, Takei M, Ogasawara S, Uchida M, Tsukida K, Tashiro M. Brainstem infarction associated with HHV-6 infection in an infant. Brain Dev. 40(3): 242-246. 2018
21. Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Okubo J, Park MJ, Sotomatsu M, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe K, Miyano S, Ogawa S, Hayashi Y. RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis. Blood. 131(20): 2266-2270. 2018