Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Clinical Sciences

Diagnostic Radiology and Nuclear Medicine

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Professor Tsushima Yoshito
Associate Professors Higuchi Tetsuya
Nakajima Takahito
Associate Professors Taketomi-Takahashi Ayako
Assistant Professors Miyazaki Masaya
Shibuya Kei
Hirasawa Hiromi
Tokue Hiroyuki
Katsumata Natsumi
Kodaira Sayaka
Tomonaga Hiroyasu
Kumasaka Souma
K Achmad A.P

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Research & Education

Research content

We aim to develop advanced, cutting edge medicine.
1) Developing new imaging technology using CT, MRI and US
2) Developing techniques for disease diagnosis using morphologic and functional imaging
3) Elucidating pathology using imaging techniques
4) Radiologic analysis of phyisiological function (functional imaging)
5) Minimally invasive therapy using interventional radiology
6) Developing new radiopharmaceuticals for PET and general nuclear medicine examinations
7) Developing novel tumor specific radioisotope therapy techniques using radiolabeled monoclonal antibodies

Business education

1) Imaging diagnosis (4th year)
2) Radioisotope therapy (4th year)
3) Radiation basic medicine (3nd year)
4) Clinical rotation (5th year)
5) Clinical rotation (6th year)

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Clinical Activities

We perform nearly all imaging examinations (CT, MRI, US, nuclear medicine, PET) in this hospital. We also perform therapy using angiographic and other imaging techniques (interventional radiology), and are especially active in therapy of liver tumors and many emergency interventional procedures such as those for angioplasty and gastrointestinal hemorrhage. CT guided biopsies and radiofrequency ablation for lung, bone and liver tumors are also part of interventional radiology. Radioisotope therapy is another part of our work. We have an outpatient clinic and inpatient ward for patients referred to us from outside institutions for interventional procedures, specialized imaging diagnosis, or radioisotope therapy.

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Citizenship Activities

Open Film Conference (OFC)

CT/ MRI research meeting

Gunma IVR meeting

Gunma MR medical research meeting

Gunma Nuclear Medicine research meeting

Clinical imaging diagnosis discussion group

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1. Fukushima Y, Miyazawa H, Nakamura J, Taketomi-Takahashi A, Suto T, Tsushima Y: Contrast-induced nephropathy (CIN) of patients with renal dysfunction in CT examination. Jpn J Radiol. 2017 Aug;35(8):427-431. doi: 10.1007/s11604-017-0649-4.

2. Erdene K, Nakajima T, Kameo S, Khairinisa MA, Lamid-Ochir O, Tumenjargal A, Koibuchi N, Koyama H, Tsushima Y: Organ retention of gadolinium in mother and pup mice: effect of pregnancy and type of gadolinium-based contrast agents. Jpn J Radiol. 2017 Oct;35(10):568-573. doi: 10.1007/s11604-017-0667-2.

3. Heryanto YD, Hanaoka H, Nakajima T, Yamaguchi A, Tsushima Y: Applying near-infrared photoimmunotherapy to B-cell lymphoma: comparative evaluation with radioimmunotherapy in tumor xenografts. Ann Nucl Med. 2017 Nov;31(9):669-677. doi: 10.1007/s12149-017-1197-9.

4. Iriuchijima A, Fukushima Y, Nakajima T, Tsushima Y, Ogura A: Simple method of size- specific dose estimates calculation from patient weight on computed tomography. Radiat Prot Dosimetry. 2018 Jan 1;178(2):208-212. doi: 10.1093/rpd/ncx100.

5. Kaira K, Higuchi T, Naruse I, Arisaka Y, Tokue A, Altan B, Suda S, Mogi A, Shimizu K, Sunaga N, Hisada T, Kitano S, Obinata H, Yokobori T, Mori K, Nishiyama M, Tsushima Y, Asao T: Metabolic activity by 18F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC. Eur J Nucl Med Mol Imaging. 2018 Jan;45(1):56-66. doi: 10.1007/s00259-017-3806-1.

6. Shinohara A, Hanaoka H, Sakashita T, Sato T, Yamaguchi A, Ishioka NS, Tsushima Y: Rational evaluation of the therapeutic effect and dosimetry of auger electrons for radionuclide therapy in a cell culture model. Ann Nucl Med. 2018 Feb;32(2):114-122. doi: 10.1007/s12149-017-1225-9.

7. Zhang X, Nakajima T, Kim M, Yamagushi A, Lamid-Ochir O, Nguyen-Thu H, Tsushima Y: Detection of epidermal growth factor receptor expressing lung squamous cell carcinoma by activatable fluorescence imaging. J Nucl Med. May 1, 2018 Vol.59 no.supplement 1 321

8. Yamaguchi A, Hanaoka H, Higuchi T, Tsushima Y: Radiolabeled (4-Fluoro-3-iodobenzyl) guanidine improves imaging and targeted radionuclide therapy of norepinephrine transporter-expressing tumors. J Nucl Med. 2018 May;59(5):815-821. doi: 10.2967/jnumed.117.201525.

9. Lamid-Ochir O, Nakajima T, Miyazaki M, Zhang X, Erdene K, Murakami T, Tsushima Y: Bioluminescence image as a quantitative imaging biomarker for preclinical evaluation of cryoablation in a murine model. J Vasc Interv Radiol. 2018 Jul;29(7):1034-1040. doi: 10.1016/j.jvir.2018.03.013.

10. Aoki M, Tokue H, Miyazaki M, Shibuya K, Hirasawa S, Oshima K: Primary postpartum hemorrhage: outcome of uterine artery embolization. Br J Radiol. 2018 Jul;91(1087):20180132. doi: 10.1259/bjr.20180132.

11. Taketomi-Takahashi A, Tsushima Y: In utero exposure to gadolinium-based contrast agents. Radiology. 2018 Aug;288(2):633-635. doi: 10.1148/radiol.2018180147.

12. Ngyen-Cong T, Ohyama Y, Taketomi-Takahashi A, Nguyen HY, Sugimoto A, Sato M, Sumiyoshi H, Nakamura T, Kurabayashi M, TsushimaY: Influence of cardiac function on image quality in coronary computed tomography angiography. Clin Imaging. 2019 Jan-Feb;53:58-64. doi: 10.1016/j.clinimag.2018.10.010.

13. Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ: Distribution of cerebral microbleeds in the East and West: individual participant meta-analysis. Neurology. 2019 Mar 5;92(10):e1086-e1097. doi: 10.1212/WNL.0000000000007039.

14. Ishizaki A, Mishiro K, Shiba K, Hanaoka H, Kinuya S, Odani A, Ogawa K: Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives. Ann Nucl Med. 2019 Apr;33(4):244-251. doi: 10.1007/s12149-018-01326-5.

15. Palangka CRAP, Hanaoka H, Yamaguchi A, Murakami T, Tsushima Y: Al18F-labeled alpha-melanocyte-stimulating hormone (α-MSH) peptide derivative for the early detection of melanoma. Ann Nucl Med. 2019 Oct;33(10):733-739. doi: 10.1007/s12149-019-01383-4.

16. Tsushima Y, Taketomi-Takahashi A: Shear wave velocity might correlate with portal venous perfusion if correct portal venous perfusion techniques are used. J Med Ultrason(2001). 2019 Oct;46(4):515-516. doi: 10.1007/s10396-019-00950-6.

17. Gu W, Yudistiro R, Hanaoka H, Tsushima Y: Bevacizumab radioimmunotherapy in triple-negative breast cancer xenograft. J Nucl Med. 2019 Oct;60(10):1405 supplement.

18. Khairinisa MA, Amano I, Miyazaki W, Koibuchi N, Tsushima Y: Gadolinium-based contrast agents toxicity in animal studies. Magn Reson Imaging. 2019 Oct;62:57-58. doi: 10.1016/j.mri.2019.05.027.

19. Tsushima Y, Hirasawa H, Wakabayashi Y, Taketomi-Takahashi A, Sutou T, Tanaka K, Takizawa M, Komatsu Y: Possible solution for the problem of unread image interpretation reports: the “Gunma university star search”. Jpn J Radiol. 2020 Mar 17. doi: 10.1007/s11604-020-00944-2.

20. Mahendra I, Hanaoka H, Yamaguchi A, Amartuvshin T, Tsushima Y: Diagnosis of bladder cancer using 18F-labeled α-methyl-phenylalanine tracers in a mouse model. Ann Nucl Med. 2020 May;34(5):329-336. doi: 10.1007/s12149-020-01452-z.

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1. Professor Yasuhito Sasaki (1985-1991). Later Professor at Tokyo University. and Chairman of National Institute of Radiological Sciences.

2. Professor Keigo Endo (1991-2010). Currently President of Kyoto College of Medical Science.

3. Professor Yoshito Tsushima (2011-present).