Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Oncology

Radiation Oncology

Our Department conducts research, education, and clinical work in a wide range of general clinical oncology with a focus on radiation oncology.  1. Research: Our Department focuses on the research of radiation oncology in which our research range from the basic research of radiation biology and medical physics to the clinical research of oncology as indicated below.  2. Education: Our department provides education in a wide range of oncology, not only on radiation biology and radiotherapy, but also on molecular biology, cancer pathology, cancer diagnosis, clinical oncology and heavy ion therapy.  3. Clinical work: Our department provides comprehensive cancer management with mainly radiotherapy for malignant tumors. As radiation oncologists, we collaborate with oncologists in other specialties and provide a complete patient care from diagnosis to treatment including provision of chemotherapy and palliative care. Especially, we are providing heavy ion therapy at our Heavy Ion Medical Research Center, one of the most cutting edge therapeutic technologies in the field of radiation therapy. 4. International activities: our groups actively contribute for International medical welfare through collaboration with the International Atomic Energy Agency (IAEA) mainly by RCA activities in health sector as well as through Federation of Asian Radiation Oncology (FARO) activities as the administrative office and as a regional office of Austral-Asian Journal of Cancer.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History

Staffs

Professor OHNO Tatsuya, M.D., PhD.
Associate professor KAWAMURA Hidemasa, M.D., PhD.
Associate professor (lecturer) OIKE Takahiro, M.D., PhD.
OKAMOTO Masahiko, M.D., PhD.
KAMINUMA Takuya, M.D., PhD.
KUBO Nobuteru, M.D., PhD.
SHIBUYA Kei, M.D.
Assistant professors ANDO Ken, M.D., PhD.
IRIE Daisuke, M.D., PhD.
OKAZAKI Shohei, M.D.,PhD.
OKANO Naoko, M.D., PhD.
SATO Hiro, M.D., PhD.
SHIBA Shintaro, M.D., PhD.
MUSHA Atsushi, M.D., PhD.

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Research & Education

Research content

1. Basic and clinical research on heavy ion therapy with cooperation of Department of Radiation Oncology at MGH/Harvard University and Heidelberg University.

2. Research on radiation biology including cancer-related genes, cellular growth factor receptors, hypoxia, and their signal pathway related to radio-sensitivity, radiation-induced apoptosis, and visualization of in vivo hypoxic cells using hypoxic cellular markers.

3. Research on the use of FDG-PET in diagnosis and treatment of malignant tumors.

4. Research on Image guided radiation therapy, especially development of image guided brachytherapy for cervical cancer, hybrid brachytherapy,

5. Clinical research on radiotherapy for prostate cancer, cervical cancer, lung cancer, malignant lymphoma, and so on.

6. Research on medical physics including dose distribution analysis, respiratory gaited radiation therapy, and design of new therapeutic and diagnostic technology.

Business education

Education in the School of Medicine:
Our Department provides lectures and clinical clerkships on radiation biology and radiotherapy for the medical students so that they can gain the basic knowledge of radiation oncology necessary for medical doctors.

Education in the Graduate School of Medicine:
Our Department provides a wide range of education opportunities including classical radiation biology, radiotherapy, molecular biology, pathology, and other oncology fields and fosters researchers and clinical oncology specialists in the field of radiation oncology. Especially, our Department promotes the advanced research on heavy ion therapy.

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Clinical Activities

1. Radiotherapy: Our Department provides radiotherapy for more than 900 new patients per year (brain tumors, head and neck cancers, lung cancer, breast cancer, esophageal cancer, prostate cancer, uterine cervical cancers, lymphoma, and others): external body irradiation using three linear accelerators, low-dose rate and high-dose rate brachytherapy ( intracavitary irradiation and interstitial irradiation), radioactive iodine therapy for thyroid cancers, and other therapies.

2. Heavy Ion Therapy: Our Department has started heavy ion therapy from March, 2010 and treated patients with head and neck cancers, lung cancer, liver cancer, prostate cancer, and bone and soft tissue tumors. By the 2014 fiscal year, we have treated more than 1500 patients with heavy ion therapy, and in the 2015 fiscal year, we expect to treat approximately 600 patients.

3. In-Patient Care; Other than radiotherapy, our Department provides chemotherapy and palliative care for cancer patients.

4. Diagnosis of patients with malignant tumors: Our Department provides diagnosis using imaging modalities such as X-rays, CT, MRI, ultrasonography, PET, and fiber scope and decides on the treatment strategy.

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Citizenship Activities

1. Our Department contributes to the activity of the International Atomic Energy Agency (IAEA).

2. Our Department provides research and educational workshops and lectures to promote heavy ion therapy as well as radiation oncology in Japan and the World.

3. Prof. Ohno has been chairing the Gynecologic Oncology Group of the Japanese Radiation Oncology Study Group (JROSG), and our department contributes to the development of gynecologic cancer research.

4. As the administrative office of Gunma Conference for Therapeutic Radiology and Oncology, our Department contributes to the development of radiation oncology and cancer therapy in the Gunma region.

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Achievements

Shibuya K, Ohno T, Katoh H, Okamoto M, Shiba S, Koyama Y, Kakizaki S, Shirabe K, Nakano T. A feasibility study of high-dose hypofractionated carbon ion radiation therapy using four fractions for localized hepatocellular carcinoma measuring 3cm or larger. Radiother Oncol PMID:30366726

Hagiwara Y, Oike T, Niimi A, Yamauchi M, Sato H, Limsirichaikul S, Held KD, Nakano T, Shibata A. Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation. J Radiat Res PMID:30476166

Kawahara M, Kawamura H, Kubota Y, Katoh H, Kubo N, Shimada H, Torikai K, Torikoshi M, Kanai T, Nakano T. MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment. J Radiat Res PMID:30668869

Parajuli RK, Sakai M, Kada W, Torikai K, Kikuchi M, Arakawa K, Torikoshi M, Nakano T. Annihilation gamma imaging for carbon ion beam range monitoring using Si/CdTe Compton camera. Phys Med Biol PMID:30669125

Permata TBM, Hagiwara Y, Sato H, Yasuhara T, Oike T, Gondhowiardjo S, Held KD, Nakano T, Shibata A. Base excision repair regulates PD-L1 expression in cancer cells. Oncogene PMID:30755733

Shibuya K, Kasama S, Funada R, Katoh H, Tsushima Y. Kounis syndrome induced by contrast media: A case report and review of literature. Eur J Radiol Open PMID:30805421

Takakusagi Y, Kawamura H, Okamoto M, Kaminuma T, Kubo N, Mizukami T, Sato H, Onishi M, Ohtake N, Sekihara T, Nakano T. Long-term outcome of hypofractionated intensity-modulated radiotherapy using TomoTherapy for localized prostate cancer: A retrospective study. PLoS One PMID:30807581

Okonogi N, Wakatsuki M, Kato S, Karasawa K, Miyasaka Y, Murata H, Nakano T, Kamada T, Shozu M; Working Group of Gynecological Tumors.. A Phase 1/2 Study of Carbon Ion Radiotherapy with Concurrent Chemotherapy for Locally Advanced Uterine Cervical Squamous Cell Carcinoma (Protocol 1302). Int J Radiat Oncol Biol Phys PMID:30825494

Li Y, Kubota Y, Tashiro M, Ohno T. Value of Three-Dimensional Imaging Systems for Image-Guided Carbon Ion Radiotherapy. Cancers (Basel) PMID:30832346

Ebara T, Ando K, Eishima J, Suzuki M, Kawakami T, Horikoshi H, Tamaki Y. Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous cell carcinoma. Jpn J Radiol PMID:30915648

Ohno T, Okamoto M. Carbon ion radiotherapy as a treatment modality for paediatric cancers. Lancet Child Adolesc Health PMID:30948250

Kubota Y, Ohno T, Kawashima M, Murata K, Okonogi N, Noda SE, Tsuda K, Sakai M, Tashiro M, Nakano T. Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer. Anticancer Res PMID:30952733

Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T. In Reply to Minhas and Tran. Int J Radiat Oncol Biol Phys PMID:30967232

Okonogi N, Kaminuma T, Okimoto T, Shinoto M, Yamamoto N, Yamada S, Murata K, Ohno T, Shioyama Y, Tsuji H, Nakano T, Kamada T. Carbon-ion radiotherapy for lymph node oligo-recurrence: a multi-institutional study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS). Int J Clin Oncol PMID:30968270

Shirai K, Ohno T, Saitoh JI, Okamoto M, Katoh H, Murata K, Kawamura H, Musha A, Abe T, Mizukami T, Akahane K, Nakano T. Prospective Study of Isolated Recurrent Tumor Re-irradiation With Carbon-Ion Beams. Front Oncol PMID:30972294

Murata H, Okonogi N, Wakatsuki M, Kato S, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M, The Working Group Of Gynecological Tumors TWGOG. Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma. Cancers (Basel) PMID:30987391

Kubota Y, Katoh H, Shibuya K, Shiba S, Abe S, Sakai M, Yuasa D, Tsuda K, Ohno T, Nakano T. Comparison between bone matching and marker matching for evaluation of intra- and inter-fractional changes in accumulated dose of carbon ion radiotherapy for hepatocellular carcinoma. Radiother Oncol PMID:31078014

Okazaki S, Murata K, Noda SE, Kumazaki Y, Hirai R, Igari M, Abe T, Komatsu S, Nakano T, Kato S. Dose-volume parameters and local tumor control in cervical cancer treated with central-shielding external-beam radiotherapy and CT-based image-guided brachytherapy. J Radiat Res PMID:31111896

Wakatsuki M, Kato S, Ohno T, Banu PA, Hoang NC, Yadamsuren E, Supriana N, Cao J, Devi CRB, Calaguas MJ, Chansilpa Y, Cho CK, Adylkhanov T, Okonogi N, Nakano T, Tsujii H. Multi-institutional observational study of prophylactic extended-field concurrent chemoradiotherapy using weekly cisplatin for patients with pelvic node-positive cervical cancer in East and Southeast Asia. Int J Radiat Oncol Biol Phys PMID:31125594

Tashiro M, Kubota Y, Torikoshi M, Ohno T, Nakano T. Divided-volume matching technique for volume displacement estimation of patient positioning in radiation therapy. Phys Med PMID:31153388

Tsuchida K, Murakami N, Kato T, Okuma K, Okamoto H, Kashihara T, Takahashi K, Inaba K, Igaki H, Nakayama Y, Nakano T, Itami J. Postoperative pelvic intensity-modulated radiation therapy reduced the incidence of late gastrointestinal complications for uterine cervical cancer patients. J Radiat Res PMID:31251358

Kubo N, Kawamura H, Oike T, Sato H, Iwanaga M, Mizukami T, Adachi A, Matsui H, Ito K, Suzuki K, Nakano T. Hypofractionated Intensity-modulated Radiotherapy for Intermediate- and High-risk Prostate Cancer: A Retrospective Study. In Vivo PMID:31280214

Nakano T, Sakai M, Torikai K, Suzuki Y, Noda SE, Yamaguchi M, Takeda S, Nagao Y, Kikuchi M, Odaka H, Kamiya T, Kawachi N, Watanabe S, Arakawa K, Takahashi T. Imaging of 99mTc-DMSA and 18F-FDG in humans using a Si/CdTe Compton camera. Phys Med Biol PMID:31323647

Anakura M, Nachankar A, Kobayashi D, Amornwichet N, Hirota Y, Shibata A, Oike T, Nakano T. Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses. Int J Mol Sci PMID:31349558

Itabashi Y, Kubota Y, Okamoto M, Tsuda K, Shiba S, Hoshino Y, Suto T, Ohno T, Nakano T. Potential Pitfalls of Diaphragm Structural Matching in Carbon-ion Radiotherapy for Pancreatic Cancer. Anticancer Res PMID:31366529

Shiba S, Shibuya K, Katoh H, Kaminuma T, Miyazaki M, Kakizaki S, Shirabe K, Ohno T, Nakano T. A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study. Radiat Oncol PMID:31375120

Shiba S, Okamoto M, Kiyohara H, Ohno T, Kaminuma T, Asao T, Ojima H, Shirabe K, Kuwano H, Nakano T. Prospective Observational Study of High-Dose Carbon-Ion Radiotherapy for Pelvic Recurrence of Rectal Cancer (GUNMA 0801). Front Oncol PMID:31417874

Komatsu S, Oike T, Komatsu Y, Kubota Y, Sakai M, Matsui T, Nuryadi E, Permata TBM, Sato H, Kawamura H, Okamoto M, Kaminuma T, Murata K, Okano N, Hirota Y, Ohno T, Saitoh JI, Shibata A, Nakano T. Deep learning-assisted literature mining for in vitro radiosensitivity data. Radiother Oncol PMID:31431384

Kubo N, Kubota Y, Kawamura H, Oike T, Sakai M, Kumazawa T, Miyasaka Y, Okazaki S, Kobayashi D, Sato H, Mizukami T, Musha A, Shirai K, Saitoh JI, Yokoo S, Chikamatsu K, Ohno T, Nakano T. Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma. Radiother Oncol PMID:31439449

Shirai K, Kubota Y, Ohno T, Saitoh JI, Abe T, Mizukami T, Mori Y, Kawamura H, Akahane K, Nakano T. Carbon-ion Radiotherapy for Isolated Lymph Node Metastasis After Surgery or Radiotherapy for Lung Cancer. Front Oncol PMID:31448233 Matsui T, Nuryadi E, Komatsu S, Hirota Y, Shibata A, Oike T, Nakano T. Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity. Int J Mol Sci PMID:31450688

Sakai M, Kubota Y, Parajuli RK, Kikuchi M, Arakawa K, Nakano T. Compton imaging with (99m)Tc for human imaging. Sci Rep PMID:31501461

Kobayashi D, Okonogi N, Wakatsuki M, Miyasaka Y, Kiyohara H, Ohno T, Kato S, Nakano T, Kamada T. Impact of CT-based brachytherapy in elderly patients with cervical cancer. Brachytherapy PMID:31506225

Kawamura H, Kubo N, Sato H, Miyasaka Y, Matsui H, Ito K, Suzuki K, Ohno T. Quality of life in prostate cancer patients receiving particle radiotherapy: A review of the literature. Int J Urol PMID:31512285

Saitoh JI, Shirai K, Mizukami T, Abe T, Ebara T, Ohno T, Minato K, Saito R, Yamada M, Nakano T. Hypofractionated carbon-ion radiotherapy for stage I peripheral nonsmall cell lung cancer (GUNMA0701): Prospective phase II study. Cancer Med PMID:31532584

Darwis NDM, Nachankar A, Sasaki Y, Matsui T, Noda SE, Murata K, Tamaki T, Ando K, Okonogi N, Shiba S, Irie D, Kaminuma T, Kumazawa T, Anakura M, Yamashita S, Hirakawa T, Kakoti S, Hirota Y, Tokino T, Iwase A, Ohno T, Shibata A, et al. FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy. Int J Mol Sci 31540114

Ikeda H, Muratani M, Hidema J, Hada M, Fujiwara K, Souda H, Yoshida Y, Takahashi A. Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity. Int J Mol Sci PMID:31561588

Kubota Y, Okamoto M, Li Y, Shiba S, Okazaki S, Komatsu S, Sakai M, Kubo N, Ohno T, Nakano T. Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients. Cancers (Basel) PMID:31569617

Kakoti S, Yamauchi M, Gu W, Kato R, Yasuhara T, Hagiwara Y, Laskar S, Oike T, Sato H, Held KD, Nakano T, Shibata A. p53 deficiency augments nucleolar instability after ionizing irradiation. Oncol Rep PMID:31578593 Matsui T, Oike T, Shirai K, Ohno T. Definitive Radiation Therapy for Merkel Cell Carcinoma Misdiagnosed as a Metastatic Tumor: A Case Report. Cureus PMID:31656712

Kobayashi D, Sato H, Saitoh JI, Oike T, Nakajima A, Noda SE, Kato S, Iwanaga M, Shimizu T, Nakano T. Efficacy and Feasibility of Salvage Re-Irradiation with CyberKnife for In-Field Neck Lymph Node Recurrence: A Retrospective Study. J Clin Med PMID:31703442

Puspitasari A, Yamazaki H, Kawamura H, Nakano T, Takahashi A, Shirao T, Held KD. X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity. Neurosci Res PMID:31711782

Ma L, Kambe R, Tsuchiya T, Kanegasaki S, Takahashi A. Anti-Metastatic Benefits Produced by Hyperthermia and a CCL3 Derivative. Cancers (Basel) PMID:31717914

Okonogi N, Wakatsuki M, Kato S, Murata H, Kiyohara H, Karasawa K, Ohno T, Tsuji H, Nakano T, Shozu M; Working Group of Gynecological Tumors.. Significance of concurrent use of weekly cisplatin in carbon-ion radiotherapy for locally advanced adenocarcinoma of the uterine cervix: A propensity score-matched analysis. Cancer Med PMID:31891228

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History

March, 1950
Dr. Tatsuo Tobe was appointed as an associate professor in Gunma University School of Medicine.

April, 1958
Department of Radiology was established in the Gunma University Hospital.

March, 1959
The Department of Radiation Medicine was established in Gunma University School of Medicine; Prof. Tatsuo Tobe was appointed as the first professor.

September, 1959
The hospital wards for the Department of Radiology was established in Gunma University Hospital.

April, 1968
Prof. Tatsuo Tobe made an assignment report in the annual meeting of Japan Radiological Society.

April, 1974
Prof. Teruo Nagai was appointed as the second professor.

November, 1980
The 20th Annual Meeting of the Japanese Society of Nuclear Medicine was held (President: Prof. Teruo Nagai).

April, 1991
Prof. Hideo Niibe was appointed as the third professor.

November 1998
The 11th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology was held (President: Prof. Hideo Niibe).

December, 2000
Prof. Takashi Nakano was appointed as the fourth professor.

September, 2001
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

July, 2002
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

April, 2003
Following the establishment of Gunma University Graduate School of Medicine, the Department was re-established as the Department of Radiation Oncology, Subdivision of Oncology.

December, 2003
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

July, 2004
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

June, 2005
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

October, 2006
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

May, 2007
The 13th Annual Meeting on the Sensitization of Cancer Treatment was held (Coordinator: Prof. Takashi Nakano).

June, 2007
The 9th Annual Meeting of Japanese Group of Brachytherapy / Japanese Society for Therapeutic Radiology and Oncology was held (Coordinator: Prof. Takashi Nakano).

January, 2008
“Gunma University Symposium on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors from Africa (Coordinator: Prof. Takashi Nakano).

December, 2008
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

January, 2009
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

November, 2009
IAEA/RCA project (RAS/6/048) Final Review Meeting (Project Lead Country Coordinator: Prof. Takashi Nakano).

February, 2010
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

March, 2010
Gunma University Heavy Ion Medical Center was established. The heavy ion therapy was started.

May, 2010
The 49th Annual Meeting of the Particle Therapy Co-Operative Group was held (President: Prof. Takashi Nakano).

October, 2011
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

November, 2015
The 28th Annual Meeting of the Japanese Society for Radiation Oncology was held (President: Prof. Takashi Nakano).

October, 2016
The 54th Annual Meeting of Japan Society of Clinical Oncology was held (President: Prof. Takashi Nakano).

October, 2019
Prof. Tatsuya Ohno was appointed as the fifth professor.