Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Oncology

Radiation Oncology

Our Department conducts research, education, and clinical work in a wide range of general clinical oncology with a focus on radiation oncology.  1. Research: Our Department focuses on the research of radiation oncology in which our research range from the basic research of radiation biology and medical physics to the clinical research of oncology as indicated below.  2. Education: Our department provides education in a wide range of oncology, not only on radiation biology and radiotherapy, but also on molecular biology, cancer pathology, cancer diagnosis, clinical oncology and heavy ion therapy.  3. Clinical work: Our department provides comprehensive cancer management with mainly radiotherapy for malignant tumors. As radiation oncologists, we collaborate with oncologists in other specialties and provide a complete patient care from diagnosis to treatment including provision of chemotherapy and palliative care. Especially, we are providing heavy ion therapy at our Heavy Ion Medical Research Center, one of the most cutting edge therapeutic technologies in the field of radiation therapy. 4. International activities: our groups actively contribute for International medical welfare through collaboration with the International Atomic Energy Agency (IAEA) mainly by RCA activities in health sector as well as through Federation of Asian Radiation Oncology (FARO) activities as the administrative office and as a regional office of Austral-Asian Journal of Cancer.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History

Staffs

Professor OHNO Tatsuya, M.D., PhD.
Associate professor KAWAMURA Hidemasa, M.D., PhD.
Associate professor (lecturer) OKAMOTO Masahiko, M.D., PhD.
KAMINUMA Takuya, M.D., PhD.
OIKE Takahiro, M.D., PhD.
SHIBUYA Kei, M.D.
KUBO Nobuteru, M.D., PhD.
Assistant professors SATO Hiro, M.D., PhD.
MUSHA Atsushi, M.D., PhD.
MURATA Kazutoshi, M.D., PhD.
OKANO Naoko, M.D., PhD.
IRIE Daisuke, M.D., PhD.
SHIBA Shintaro, M.D., PhD.

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Research & Education

Research content

1. Basic and clinical research on heavy ion therapy with cooperation of Department of Radiation Oncology at MGH/Harvard University and Heidelberg University.

2. Research on radiation biology including cancer-related genes, cellular growth factor receptors, hypoxia, and their signal pathway related to radio-sensitivity, radiation-induced apoptosis, and visualization of in vivo hypoxic cells using hypoxic cellular markers.

3. Research on the use of FDG-PET in diagnosis and treatment of malignant tumors.

4. Research on Image guided radiation therapy, especially development of image guided brachytherapy for cervical cancer, hybrid brachytherapy,

5. Clinical research on radiotherapy for prostate cancer, cervical cancer, lung cancer, malignant lymphoma, and so on.

6. Research on medical physics including dose distribution analysis, respiratory gaited radiation therapy, and design of new therapeutic and diagnostic technology.

Business education

Education in the School of Medicine:
Our Department provides lectures and clinical clerkships on radiation biology and radiotherapy for the medical students so that they can gain the basic knowledge of radiation oncology necessary for medical doctors.

Education in the Graduate School of Medicine:
Our Department provides a wide range of education opportunities including classical radiation biology, radiotherapy, molecular biology, pathology, and other oncology fields and fosters researchers and clinical oncology specialists in the field of radiation oncology. Especially, our Department promotes the advanced research on heavy ion therapy.

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Clinical Activities

1. Radiotherapy: Our Department provides radiotherapy for more than 900 new patients per year (brain tumors, head and neck cancers, lung cancer, breast cancer, esophageal cancer, prostate cancer, uterine cervical cancers, lymphoma, and others): external body irradiation using three linear accelerators, low-dose rate and high-dose rate brachytherapy ( intracavitary irradiation and interstitial irradiation), radioactive iodine therapy for thyroid cancers, and other therapies.

2. Heavy Ion Therapy: Our Department has started heavy ion therapy from March, 2010 and treated patients with head and neck cancers, lung cancer, liver cancer, prostate cancer, and bone and soft tissue tumors. By the 2014 fiscal year, we have treated more than 1500 patients with heavy ion therapy, and in the 2015 fiscal year, we expect to treat approximately 600 patients.

3. In-Patient Care; Other than radiotherapy, our Department provides chemotherapy and palliative care for cancer patients.

4. Diagnosis of patients with malignant tumors: Our Department provides diagnosis using imaging modalities such as X-rays, CT, MRI, ultrasonography, PET, and fiber scope and decides on the treatment strategy.

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Citizenship Activities

1. Collaboration in the activity of the International Atomic Energy Agency (IAEA): Our Department contributes to the IAEA regional project on radiotherapy in the Asia-Pacific region. Prof. Nakano had been the Thematic Sector Lead Country Coordinator for Human Health for IAEA/RCA activities.

2. Our Department provides research and educational workshops and lectures to promote heavy ion therapy as well as radiation oncology in Japan and the World.

3. As a regional office of Austral-Asian Journal of Cancer, our Department contributes to the development of cancer research in the Asia-Pacific region.

4. As the administrative office of Federation of Asian Radiation Oncology (FARO), our Department contributes to the development of cancer care and research in the Asian region.

5. As the administrative office of NPO Japanese Organization for International Cooperation in Radiation Medicine, we make the international cooperation activities to develop radiation medicine in Asia by supporting international contribution of our country.

6. As the administrative office of Gunma Conference for Therapeutic Radiology and Oncology, our Department contributes to the development of radiation oncology and cancer therapy in the Gunma region.

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Achievements

Shibuya K, Ohno T, Katoh H, Okamoto M, Shiba S, Koyama Y, Kakizaki S, Shirabe K, Nakano T.
A feasibility study of high-dose hypofractionated carbon ion radiation therapy using four fractions for localized hepatocellular carcinoma measuring 3 cm or larger.
Radiother Oncol. 2018 Oct 23. pii: S0167-8140(18)33521-7.

Abe T, Ohno T, Koto M, Demizu Y, Suefuji H, Tsuji H, Okimoto T, Shioyama Y, Saitoh JI, Shirai K, Nemoto K, Nakano T, Kamada T;
Japan Carbon-Ion Radiation Oncology Study Group. A multi-institutional retrospective study of carbon-ion radiotherapy for non-squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon-Ion Radiation Oncology Study Group study 1402 HN.
Cancer Med. 2018 Dec; 7(12): 6077-6083.

Saitoh JI, Shirai K, Abe T, Kubo N, Ebara T, Ohno T, Minato K, Saito R, Yamada M, Nakano T;
WORKING GROUP OF THE LUNG TUMOR. A Phase I Study of Hypofractionated Carbon-ion Radiotherapy for Stage III Non-small Cell Lung Cancer.
Anticancer Res. 2018 Feb; 38(2):885-891.

Hagiwara Y, Sato H, Permata TBM, Niimi A, Yamauchi M, Oike T, Nakano T, Shibata A.
Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.
Hum Immunol. 2018 Aug; 79(8): 627-631.

Irie D, Okonogi N, Wakatsuki M, Kato S, Ohno T, Karasawa K, Kiyohara H, Kobayashi D, Tsuji H, Nakano T, Kamada T, Shozu M; and The Working Group of the Gynecological Tumor.
Carbon-ion radiotherapy for inoperable endometrial carcinoma.
J Radiat Res. 2018 May 1;59(3):309-315.

Shiba S, Okamoto M, Kiyohara H, Okano N, Yoshimoto Y, Murata H, Irie D, Katoh H, Nakano T.
Clinical Advantage of Chest-wall Post-mastectomy Radiation Therapy Without Bolus.
In Vivo. 2018 Jul-Aug;32(4):961-965.

Hagiwara Y, Oike T, Niimi A, Yamauchi M, Sato H, Limsirichaikul S, Held KD, Nakano T, Shibata A.
Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation.
J Radiat Res. 2018 Nov 22.

Musha A, Ogawa M, Yokoo S. Granular cell tumors of the tongue: fibroma or schwannoma. Head Face Med. 2018 Jan 3;14(1):1.

Nuryadi E, Mayang Permata TB, Komatsu S, Oike T, Nakano T.
Inter-assay precision of clonogenic assays for radiosensitivity in cancer cell line A549.
Oncotarget. 2018 Feb 7;9(17):13706-13712.

Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, et al.
Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.
Oncotarget. 2018 Aug 24;9(66):32642-32652.

Shiba S, Shibuya K, Katoh H, Koyama Y, Okamoto M, Abe T, Ohno T, Nakano T.
No Deterioration in Clinical Outcomes of Carbon Ion Radiotherapy for Sarcopenia Patients with Hepatocellular Carcinoma.
Anticancer Res. 2018 Jun;38(6):3579-3586.

Ohno T, Noda SE, Murata K, Yoshimoto Y, Okonogi N, Ando K, Tamaki T, Kato S, Hirakawa T, Kanuma T, Minegishi T, Nakano T; Working Group for Gynecologic Cancer.
Phase I Study of Carbon Ion Radiotherapy and Image-Guided Brachytherapy for Locally Advanced Cervical Cancer.
Cancers (Basel). 2018 Sep 18;10(9).

Okazaki S, Abe T, Takayanagi N, Yasuda M, Sakai F, Kobayashi K, Kato S.
Pulmonary Tumor Embolism Due to Squamous Cell Carcinoma of the Uterine Cervix: A Case Report.
In Vivo. 2018 Mar-Apr;32(2):337-343.

Shibuya K, Ohno T, Terashima K, Toyama S, Yasuda S, Tsuji H, Okimoto T, Shioyama Y, Nemoto K, Kamada T, Nakano T; Japan Carbon Ion Radiotherapy Study Group.
Short-course carbon-ion radiotherapy for hepatocellular carcinoma: A multi-institutional retrospective study.
Liver Int. 2018 Dec;38(12):2239-2247.

Ando K, Suzuki Y, Kaminuma T, Yoshimoto Y, Oike T, Okonogi N, Sato H, Tamaki T, Noda SE, Mimura K, Nakano T.
Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia.
Int J Hyperthermia. 2018;35(1):226-231.

Kubo N, Harimoto N, Shibuya K, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Araki K, Miyazaki M, Kuwano H, Shirabe K.
Successful treatment of isolated bile leakage after hepatectomy combination therapy with percutaneous transhepatic portal embolization and bile duct ablation with ethanol: a case report.
Surg Case Rep. 2018 Jun 19;4(1):61.

Lee SH, Sunaguchi N, Hirano Y, Kano Y, Liu C, Torikoshi M, Ohno T, Nakano T, Kanai T.
A carbon CT system: how to obtain accurate stopping power ratio using a Bragg peak reduction technique.
Phys Med Biol. 2018 Jan 31;63(3):035025.

Keawsamur M, Matsumura A, Souda H, Kano Y, Torikoshi M, Nakano T, Kanai T.
Development of stereotactic radiosurgery using carbon beams (carbon-knife).
Phys Med Biol. 2018 Feb 20;63(4):045024. doi: 10.1088/1361-6560/aaaa4d.

Kubota Y, Hayashi H, Abe S, Souda S, Okada R, Ishii T, Tashiro M, Torikoshi M, Kanai T, Ohno T, Nakano T.
Evaluation of the accuracy and clinical practicality of a calculation system for patient positional displacement in carbon ion radiotherapy at five sites.
J Appl Clin Med Phys. 2018 Mar;19(2):144-153.

Sakai M, Yamaguchi M, Nagao Y, Kawachi N, Kikuchi M, Torikai K, Kamiya T, Takeda S, Watanabe S, Takahashi T, Arakawa K, Nakano T.
In vivo simultaneous imaging with (99m)Tc and (18)F using a Compton camera.
Phys Med Biol. 2018 Oct 16;63(20):205006.

Hirano Y, Kodaira S, Souda H, Matsumura A, Torikoshi M.
Linear energy transfer (LET) spectra and survival fraction distribution based on the CR-39 plastic charged-particle detector in a spread-out Bragg peak irradiation by a (12)C beam.
Phys Med Biol. 2018 Sep 10;63(18):185006.

Bridges D, Kawamura H, Kanai T.
Probabilistic dose distribution from interfractional motion in carbon ion radiation therapy for prostate cancer shows rectum sparing with moderate target coverage degradation.
PLoS One. 2018 Aug 31;13(8):e0203289.

Sakai M, Kubota Y, Saitoh JI, Irie D, Shirai K, Okada R, Torikoshi M, Ohno T, Nakano T.
Robustness of patient positioning for interfractional error in carbon ion radiotherapy for stage I lung cancer: Bone matching versus tumor matching.
Radiother Oncol. 2018 Oct;129(1):95-100.

Kubota Y, Sakai M, Tashiro M, Saitoh JI, Abe T, Ohno T, Nakano T.
Technical Note: Predicting dose distribution with replacing stopping power ratio for inter-fractional motion and intra-fractional motion during carbon ion radiotherapy with passive irradiation method for stage I lung cancer.
Med Phys. 2018 Jul;45(7):3435-3441.

Paz AE, Yamamoto N, Sakama M, Matsufuji N, Kanai T.
Tumor Control Probability Analysis for Single-Fraction Carbon-Ion Radiation Therapy of Early-Stage Non-small Cell Lung Cancer.
Int J Radiat Oncol Biol Phys. 2018 Aug 2.

Yoshida Y, Sejimo Y, Kurachi M, Ishizaki Y, Nakano T, Takahashi A.
X-ray irradiation induces disruption of the blood-brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain.
Neurochem Int. 2018 Oct;119:199-206.

Mizuno H, Fukumura A, Kanematsu N, Yonai S, Shirai T, Yusa K, Yanou T, Suga M, Mizota M, Minohara S, Kanai T, Kamada T.
External dosimetry audit for quality assurance of carbon-ion radiation therapy clinical trials. J Appl Clin Med Phys. 2018 Nov 1.

Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.
Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.
Int J Mol Sci. 2018 Dec 9;19(12).

Sakai M, Parajuli RK, Kikuchi M, Yamaguchi M, Nagao Y, Kawachi N, Arakawa K, Nakano T.
Effect of number of views on cross-sectional Compton imaging: A fundamental study with backprojection. Phys Med. 2018 Dec;56:1-9.

Okonogi N, Wakatsuki M, Kato S, Karasawa K, Kiyohara H, Shiba S, Kobayashi D, Nakano T, Kamada T, Shozu M; Working Group of Gynecological Tumors.
Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001).
Cancer Med. 2018 Feb;7(2):351-359.

Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T.
Combination Therapy of Intravenously Injected Microglia and Radiation Therapy Prolongs Survival in a Rat Model of Spontaneous Malignant Glioma.
Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):601-608.

Okonogi N, Fukahori M, Wakatsuki M, Ohkubo Y, Kato S, Miyasaka Y, Tsuji H, Nakano T, Kamada T.
Dose constraints in the rectum and bladder following carbon-ion radiotherapy for uterus carcinoma: a retrospective pooled analysis.
Radiat Oncol. 2018 Jun 25;13(1):119.

Onishi M, Okonogi N, Oike T, Yoshimoto Y, Sato H, Suzuki Y, Kamada T, Nakano T.
High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells.
J Radiat Res. 2018 Sep 1;59(5):541-546.

Okonogi N, Kobayashi D, Suga T, Imai T, Wakatsuki M, Ohno T, Kato S, Nakano T, Kamada T.
Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer.
Oncol Lett. 2018 Jan;15(1):459-466.

Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M; WORKING GROUP OF GYNECOLOGICAL TUMORS.
Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix.
Anticancer Res. 2018 Jan;38(1):457-463.

Murata H, Okamoto M, Takahashi T, Motegi M, Ogoshi K, Shoji H, Onishi M, Takakusagi Y, Okonogi N, Kawamura H, Okazaki A, Asao T, Kuwano H, Nakano T.
SUV(max)-based Parameters of FDG-PET/CT Reliably Predict Pathologic Complete Response After Preoperative Hyperthermo-chemoradiotherapy in Rectal Cancer.
Anticancer Res. 2018 Oct;38(10):5909-5916.

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History

March, 1950
Dr. Tatsuo Tobe was appointed as an associate professor in Gunma University School of Medicine.

April, 1958
Department of Radiology was established in the Gunma University Hospital.

March, 1959
The Department of Radiation Medicine was established in Gunma University School of Medicine; Prof. Tatsuo Tobe was appointed as the first professor.

September, 1959
The hospital wards for the Department of Radiology was established in Gunma University Hospital.

April, 1968
Prof. Tatsuo Tobe made an assignment report in the annual meeting of Japan Radiological Society.

April, 1974
Prof. Teruo Nagai was appointed as the second professor.

November, 1980
The 20th Annual Meeting of the Japanese Society of Nuclear Medicine was held (President: Prof. Teruo Nagai).

April, 1991
Prof. Hideo Niibe was appointed as the third professor.

November 1998
The 11th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology was held (President: Prof. Hideo Niibe).

December, 2000
Prof. Takashi Nakano was appointed as the fourth professor.

September, 2001
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

July, 2002
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

April, 2003
Following the establishment of Gunma University Graduate School of Medicine, the Department was re-established as the Department of Radiation Oncology, Subdivision of Oncology.

December, 2003
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

July, 2004
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

June, 2005
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

October, 2006
IAEA/RCT Regional Training Course was held (Coordinator: Prof. Takashi Nakano).

May, 2007
The 13th Annual Meeting on the Sensitization of Cancer Treatment was held (Coordinator: Prof. Takashi Nakano).

June, 2007
The 9th Annual Meeting of Japanese Group of Brachytherapy / Japanese Society for Therapeutic Radiology and Oncology was held (Coordinator: Prof. Takashi Nakano).

January, 2008
“Gunma University Symposium on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors from Africa (Coordinator: Prof. Takashi Nakano).

December, 2008
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

January, 2009
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

November, 2009
IAEA/RCA project (RAS/6/048) Final Review Meeting (Project Lead Country Coordinator: Prof. Takashi Nakano).

February, 2010
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

March, 2010
Gunma University Heavy Ion Medical Center was established. The heavy ion therapy was started.

May, 2010
The 49th Annual Meeting of the Particle Therapy Co-Operative Group was held (President: Prof. Takashi Nakano).

October, 2011
“Gunma University Workshop on the Advanced Radiation Medicine for Cancer” was held with attendance of IAEA Ambassadors (Coordinator: Prof. Takashi Nakano).

November, 2015
The 28th Annual Meeting of the Japanese Society for Radiation Oncology was held (President: Prof. Takashi Nakano).

October, 2016
The 54th Annual Meeting of Japan Society of Clinical Oncology was held (President: Prof. Takashi Nakano).

October, 2019
Prof. Tatsuya Ohno was appointed as the fifth professor.