The main work in the Diagnostic Pathology is surgical pathology, cancer research and pathology education. In surgical pathological work, we pathologists have a common mind similar to clinician, that is, “we see a patient through microscope”. We do diagnostic work in wide field of human organs such as lung, uterine cervix, stomach, colon, breast, prostate, etc. In research, we are focusing human carcinogenesis by genetic abnormality, breast cancer and steroid hormones, human papillomavirus (HPV) infection in cervical lesions. In educational work, we are intended to provide pathological knowledge for post-graduate and undergraduate medical student as well as paramedical students.
|Professor||Tetsunari OYAMA, M.D., Ph.D.|
|Associate Professor||Takaaki SANO, M.D., Ph.D.|
|Assistant Professor||Hiromi KOSHI, M.D., Ph.D.|
|Mai SODA, D.D.S., Ph.D.|
|Ayaka KATAYAMA, M.D., Ph.D.|
Research & Education
In our department, we are clinicopathologically studying the mechanism of carcinogenesis and cancer progression and the problems about cancer therapy. In lung and alimentary tract cancers, we have studied correlation between human carcinogenesis including multi-step carcinogenesis and genetic abnormalities occurred in various oncogenes and tumor suppressor genes. Human papillomavirus (HPV) infection has been investigated on cervical cancers, and main target of this study has recently shifted from HPV detection to p16 protein, which is expected to become diagnostic tool for cervical cancer diagnosis. Moreover, we are studying hormone related carcinogenesis in mammary gland and prostate.
In our university, the curriculum for medical students is changing to new one. In 2007, it will be completed. In the education for undergraduate, our department deals with the education of general pathology as well as a part of biology and anatomic pathology. In our department, post-graduate students learn diagnostic pathology including autopsy in the first and second years and followed by research work in third and fourth years.
Our staff and post-graduate students partly shear the diagnostic and autopsy work in Gunma University Hospital.
1. Katayama A, Handa T, Komatsu K, Togo M, Horiguchi J, Nishiyama M, Oyama T. Expression patterns of claudins in patients with triple-negative breast cancer are associated with nodal metastasis and worse outcome. Pathol Int. Aug;67(8):404-413. 2017
2. Handa T, Katayama A, Yokobori T, Yamane A, Horiguchi J, Kawabata-Iwakawa R,Rokudai S, Bao P, Gombodorj N, Altan B, Kaira K, Asao T, Kuwano H, Nishiyama M,Oyama T. Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients. J Surg Oncol. Jun 1. [Epub ahead of print] 2017
3. Seki M, Sano T, Yokoo S, Oyama T. Histologic assessment of tumor budding in preoperative biopsies to predict nodal metastasis in squamous cell carcinoma of the tongue and floor of the mouth. Head Neck. Apr:38 Suppl 1:E1582-90. 2016
4. Kurozumi S, Inoue K, Takei H, Matsumoto H, Kurosumi M, Horiguchi J, Takeyoshi I, Oyama T. ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab. BMC Cancer. 7:15:622. 2015
5. Koshi H, Sano T, Handa T, Yanagawa T, Saitou K, Nagamori S, Kanai Y, Takagishi K, Oyama T. L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors. Pathol Int. 65(9):460-7. 2015
6. Nobusawa A, Negishi A, Sano T, Hirato J, Oyama T, Yokoo S. Solitary fibrous tumor composing benign and malignant components in the floor of the mouth: A case report. J Oral Maxillofac Surg Med Pathol. 27:267-270, 2015
7. Kato T, Fujii T, Ide M, Takada T, Sutoh T, Morita H, Yajima R, Yamaguchi S, Tsutsumi S, Asao T, Oyama T, Kuwano H. Effect of long interval between hyperthermochemoradiation therapy and surgery for rectal cancer on apoptosis, proliferation and tumor response. Anticancer Res. 34:3141-3146, 2014.
8. Nakajima H, Ishikawa Y, Furuya M, Sano T, Ohno Y, Horiguchi J, Oyama T. Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer. Breast Cancer. 21:66-74, 2014
9. Nobusawa A, Sano T, Yokoo S, Oyama T. Ameloblastic carcinoma developing in pre-existing ameloblastoma with a mutation of the p53 gene: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 118: e146-e150, 2014
10. Sano T, Nakamura C, Yoshida T, Oyama T. Stratified mucin-producing intraepithelial lesions (SMILEs) of the uterine cervix are associated with HPV integration. Pathol Int 64, 628-630, 2014
11. Nobusawa A, Sano T, Negishi A, Yokoo S, Oyama T. Immunohistochemical staining patterns of cytokeratins 13, 14, and 17 in oral epithelial dysplasia including orthokeratotic dysplasia. Pathol Int. 64:20-27, 2014
12. Segawa A, Nagamori S, Kanai Y, Masawa N, Oyama T. L-type amino acid transporter 1 expression is highly correlated with Gleason score in prostate cancer. Mol Clin Oncol. 1:274-280, 2013.
13. Nobusawa A, Kim M, Kaira K, Miyashita G, Negishi A, Oriuchi N, Higuchi T, Tsushima Y, Kanai Y, Yokoo S, Oyama T. Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma. Eur J Nucl Med Mol Imaging. 40:1692-1700, 2013.
In 1954, Second Department of Pathology was separated from Pathology Department and the first professor was Genjyu Ooneda come from Keiogijyuku University. He intensively studied the mechanism of atherosclerosis and brain hemorrhage. In 1980, associate professor Yoji Yoshida and assistant professor Keiji Suzuki became professor in Yamanashi Medical School and Gunma University, respectively.
In 1981, Professor Rikuo Machinami came from Tokyo University after the retirement of professor Ooneda. His specialty was the pathology of bone and soft tissue tumors as well as of liver cell carcinoma.
In 1989, Professor Takashi Nakajima came from the National Cancer Center Research Institute after professor Machinami got a new position in Tokyo University. In 1997, Assistant Professor Toshio Fukuda moved to the Faculty of Health Science and became Professor in 2003. In 2005, Associate Professor Tetsunari Oyama got a position of Professor of Department of Pathology in the Dokkyo Medical School.
In 2009, Tetsunari Oyama came from the Dokkyo Medical School again as a Professor of the Diagnostic Pathology after professor Nakajima had moved to the Shizuoka Cancer Center in 2008.