Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Clinical Sciences


Our department is a center of eye service in Gunma Prefecture and surrounding area, which have 3 million people. We provide medical service for various ophthalmologic disorders with advanced technology.
Our department is highly reputed in management of vitreoretinal diseases. We have 1400 surgeries in a year and the majority of them are vitreoretinal diseases. Our clinical research is at international level and we are developing newly surgical treatment for various vitreoretinal diseases. Residents have about two years training at university hospital. Our education course includes clinical practice under supervisor, a series of lectures and clinical conference. Postgraduate school is available after two years residency. Postgraduate school provides two courses including basic research such as molecular biology, physiology and pathology and clinical research of ophthalmology. Doctors outside the university can participate in the postgraduate school at night and week end. After graduation, there are two choices, study in abroad and advanced training in clinical ophthalmology. We accept the international fellowship in program of international federation of ophthalmic society (ICO) / international council of ophthalmology (ICO).

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History


Professor AKIYAMA Hideo, M.D.Ph.D.
Associate Professor TODOKORO Daisuke, M.D.Ph.D.
MATSUMOTO Hidetaka, M.D.Ph.D.
MUKAI Ryo ,M.D.Ph.D.
Senior Associate Professor MORIMOTO Masahiro
Assiatant Professor NODA Satomi
SINOHARA Youichiro, M.D.Ph.D.
NITTA Keisuke, M.D.Ph.D.
NAGAI Kazuki

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Research & Education

Research content

Basic research includes: metabolism of vitreous body, experimental ocular neovascularization, genetic analysis of diabetic retinopathy, fine structure of the eye using scanning electron microscopy, microcirculation of the ocular fundus in experimental animals, electrophysiology of the retina.
Clinical research includes: noninvasive observation of retinal tomography using optical coherence tomography in fundus diseases, correlation of morphologic and electrophysiological changes in retinal diseases, clinical and therapeutic aspects of diabetic retinopathy, retinal detachment and age-related macular degeneration. Study of ocular microcirculation using high-speed fluorescein angiography, laser speckle flowgraphy and OCTA.
Our major target is the fundus disease. We make an effort to find the pathological process and strategies in fundus disease. Many articles have been published from our department in peer-reviewed English journals.

Business education

We introduce the general ophthalmology to the 4th grade students in a series of lectures. We provide the clinical practice for the 5th grade students. A series of lectures for practical ophthalmology is given to the pre-graduate students.
The professor and the associates serve the lectures and practices to the graduate students. Education of basic research is collaborated with laboratories of circulatory disorders, physiology and gene analysis. We give training for ocular microcirculation using fluorescein angiography, laser speckle flowgraphy and scanning laser ophthalmoscope, in vivo histology of the retina using optical coherence tomography and retinal functional study using multifocal electroretinogram. Research achievement is written in English manuscript under our supervision.

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Clinical Activities

We provide outpatient service from Monday to Friday. We have several subspeciality clinics that include: vitreoretinal disease, corneal disease, ocular tumors, diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, glaucoma, macular edema, uveitis, strabismus, low vision and dacryocystitis. We have two days of regular operation in a week and we perform emergency surgery as needed.

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Citizenship Activities

We organize ‘Gunma Ophthalmologic Forum twice a year, where the invited specialist gives a lecture in their subspecialty.
We perform corneal transplantation in cooperation with Gunma Eye Bank and propagate the activity of Eye Bank.
We participate in the visual disability program.
We have co-operation with the group of retinal pigmentary degeneration.
We participate in the academic meeting for ophthalmologists in Gunma prefecture twice a year. We provide a training course of vitreoretinal practice for doctors from developing countries as a guest institute of ICO/IFOC international fellowship program.

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2. Matsumoto H, Mukai R, Kikuchi Y, Morimoto M, Akiyama H: One-year outcomes of half-fluence photodynamic therapy combined with intravitreal injection of aflibercept for pachychoroid neovasculopathy without polypoidal lesions. Jpn J Ophthalmol. 64(2):203-209, 2020

3. Miyakubo T, Mukai R, Nakamura K, Matsumoto H, Akiyama H: A Case of Ipilimumab-Induced Unusual Serous Retinal Detachment in Bilateral Eyes. Int Med Case Rep J. 12:355-361, 2019

4. Todokoro D, Kamei S, Goto H, Ikeda Y, Koyama H, Akiyama H: Acute retinal necrosis following herpes simplex encephalitis: a nationwide survey in Japan. Jpn J Ophthalmol. 63(4):304-309, 2019

5. Sakurada Y, Tanaka K, Miki A, Matsumoto H, Kawamura A, Mukai R, Akiyama H, Honda S, Mori R, Iijima H: Clinical characteristics of cuticular drusen in the Japanese population. Jpn J Ophthalmol. 63(6):448-456, 2019

6. Matsumoto H, Kishi S, Mukai R, Akiyama H: Remodeling of macular vortex veins in pachychoroid neovasculopathy. Sci Rep. 9(1):14689,2019

7. Matsumoto H, Mukai R, Morimoto M, Tokui S, Kishi S, Akiyama H: Clinical characteristics of pachydrusen in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol. 257(6):1127-1132, 2019


9. Matsumoto H, Morimoto M, Mimura K, Ito A, Akiyama H: Treat-and-Extend Regimen with Aflibercept for Neovascular Age-Related Macular Degeneration: Efficacy and Macular Atrophy Development. Ophthalmol Retina. 2(5):462-468, 2018

10. Kishi S, Matsumoto H, Sonoda S, Hiroe T, Sakamoto T, Akiyama H: Geographic filling delay of the choriocapillaris in the region of dilated asymmetric vortex veins in central serous chorioretinopathy. PLoS One. 13(11):e0206646, 2018

11. Mimura K, Matsumoto H, Morimoto M, Akiyama H: Development of Age-Related Macular Degeneration (AMD) in the Fellow Eye of Patients with AMD Treated by Treat-and-Extend Intravitreal Therapy with Aflibercept. Ophthalmologica. 239(2-3):121-127, 2018

12. Matsumoto H, Sugio S, Seghers F, Krizaj D, Akiyama H, Ishizaki Y, Gailly P, Shibasaki K: Retinal detachment-induced Müller glial cell swelling activates TRPV4 ion channels and triggers photoreceptor death at body temperature. J Neurosci. 38(41):8745-8758, 2018

13. Li D, Akiyama H, Kishi S. Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment. BMC Ophthalmol. 18(1):174, 2018

14. Akiyama H, Takahashi I, Shimoda Y, Mukai R, Yoshihara T, Tobita S: Ir(iii) complex-based oxygen imaging of living cells and ocular fundus with a gated ICCD camera.

Photochem Photobiol Sci. 17(6):846-853, 2018

15. Akiyama H, Li D, Shimoda Y, Matsumoto H, Kishi S: Observation of neovascularization of the disc associated with proliferative diabetic retinopathy using OCT angiography. Jpn J Ophthalmol. 62(3):286-291, 2018

16. Matsumoto H, Hiroe T, Morimoto M, Mimura K, Ito A, Akiyama H: Efficacy of treat-and-extend regimen with aflibercept for pachychoroid neovasculopathy and Type 1 neovascular age-related macular degeneration. Jpn J Ophthalmol. 62(2):144-150, 2018

17. Morimoto M, Matsumoto H, Mimura K, Akiyama H: Reply to the letter to the editor: Two-year results of treat-and-extend regimen with aflibercept for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 256(1):225-226, 2018

18. Hanyuda N, Akiyama H, Shimoda Y, Mukai R, Sano M, Shinohara Y, Kishi S: Different Filling Patterns of the Choriocapillaris in Fluorescein and Indocyanine Green Angiography in Primate Eyes Under Elevated Intraocular Pressure. Invest Ophthalmol Vis Sci. 58(13):5856-5861, 2017

19. Ito A, Matsumoto H, Morimoto M, Mimura K, Akiyama H: Two-Year Outcomes of a Treat-and-Extend Regimen Using Intravitreal Aflibercept Injections for Typical Age-Related Macular Degeneration. Ophthalmologica. 238(4):236-242, 2017

20. Morimoto M, Matsumoto H, Mimura K, Akiyama H: Two-year results of a treat-and-extend regimen with aflibercept for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 255(10):1891-1897,2017

21. Shinohara Y, Kashima T, Akiyama H. Shimoda Y, Li D, Kishi S: Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy. PLoS One. 12(1): e0169596, 2017

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Maebashi medical special school was established in 1943. The first president was Dr. Shinobu Ishihara who is ophthalmologist well known as Ishihara’s color blindness chart. The 1st Professor in our department was Dr. Shimizu Okamura (1943-44).
The 2nd Professor was Dr. Heihachi Aoki (1946-72). The main themes of department were anterior segment disorders and retinal pigment degeneration in the period.
The 3rd Professor was Dr. Koichi Shimizu (1972-98). After he introduced fluorescein angiography and laser photocoagulation, our department took a leading position in diagnosis and treatment of fundus disease at the international level.
The 4th Professor was Dr. Shoji Kishi (1998-2016). We can recognize the fundus disease as a three dimension by his discovery of precortical vitreous pocket. We clarified the pathologic process of macular hole, diabetic retinopathy, macular edema and high myopia that resulted in highly successful vitreoretinal surgery.
The 5th Professor is Dr. Hideo Akiyama (2016-).
We are developing clinical research in ocular microcirculation, in vivo histology as well as newly treatment for retinal diseases. Recently we are applying molecular biology in ophthalmology