Graduate School of Medicine / School of Medicine, Faculty of Medicine

  • Campus Map
  • Site Map
  • Contact us
  • Japanese
  • English


Otolaryngology-Head and Neck Surgery

Our goal is to provide excellent treatments through basic and clinical research works in the field of Otolaryngology – Head and Neck Surgery.
Our specialties are followings;
1) Neuroscience
2) Head and neck tumor, Reconstruction surgery
3) Cochlear implant
4) Malformation of the ear
5) Smell and taste
6) Hearing disorder and hearing aid
7) Nasal allergy
8) Operation of the vocal organs

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History


Professor CHIKAMATSU Kazuak, M.D., D.M.Sci.
Associate Professors TAKAYASU Yukihiro, M.D., D.M.Sci.
SHINO Masato, M.D., D.M.Sci.
Assiatant Professors NIKKUNI Osamu, M.D., D.M.Sci.
TAKAHASHI Hideyuki, M.D., D.M.Sci.
MATSUYAMA Toshiyuki, M.D., D.M.Sci.
TADA Hiroe, M.D.
IDA Shota, M.D.
MITO Ikko, M.D.

Top of Page

Research & Education

Research content

1)Tumor microenvironment in head and neck cancer
2)Immunosuppressive mechanisms in head and neck cancer
3)Development of cancer vaccine
4)Circulating tumor cells in head and neck cancer
5)Electrophysiology of vestibular and cerebellar neuron
6)Integration of vision and balance
7)Effect of stress to balance

Business education

Education in School of Medicine
1)Understanding of diseases in Otolaryngology-Head and Neck Surgery
2)Understanding of technique for primary care

Education in Graduate School of Medicine
1)Tumor Immunology
2)Neuroscience of balance


Top of Page

Clinical Activities

Out Patients
The medical examination; from Monday to Friday, 8:30 to 11:30 in the morning
The special examination, in the afternoon
on Monday; Children’s hearing disorder, Hearing-aid
on Wednesday; The sense of smell, Larynx, Head and neck cancer, Otitis media
on Thursday; Allergy, Cochlear implant, Balance
The Children’s hearing loss support center; early detection, checkup, and treatment for children’s hearing loss

In Patients
Operation day, on Tuesday and Friday
The rounds of patients, on Wednesday
Conference, on Friday

Top of Page

Citizenship Activities

A society and a lecture meeting for the medical association
A free clinic about hearing disorders and hearing-aid

Top of Page


1.Kubo N, Kubota Y, Kawamura H, Oike T, Sakai M, Kumazawa T, Miyasaka Y, Okazaki S, Kobayashi D, Sato H, Mizukami T, Musha A, Saitoh J-I, Yokoo S, Chikamatsu K, Ohno T, Nakano T. Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma. Radiother Oncol 2019; in press

2.Musha A, Fukata K, Saitoh JI, Shirai K, Abe T, Mizukami T, Kawashima M, Yokoo S, Chikamatsu K, Ohno T, Nakano T. Tongue surface model can predict radiation tongue mucositis due to intensity- modulated radiation therapy for head and neck cancer. Int J Oral Maxillofac Surg 2019;

3.Tsurumaki H, Matsuyama T, Ezawa K, Koga Y, Yatomi M, Aoki-Saito H, Chikamatsu K, Hisada T. Rapid effect of benralizumab for hypereosinophilia in a case of severe asthma with eosinophilic chronic rhinosinusitis. Medicina 2019;55:336.

4.Okamoto A, Sakakura K, Takahashi H, Motegi S, Kaira K, Yokobori-Kuwabara Y, Ishikawa 0, Chikamatsu K. Immunological and clinicopathological significance of MFG-E B expression in patients with oral squamous cell carcinoma. Pathol Oncol Res 2019; in press.

5.Takahashi H, Sakakura K, Arosala Y, Tokue A, Kaira K, Tada H, Higuchi T, Tsushima Y, Chikamatsu K. Clinical and biological significance of PD-L1 expression within the tumor miciroenvironment of oral squamous cell carcinoma. Anticancer Res 2019;39:3039-3046.

6.Takahashi H, Sakakura K, Tada H, Kaira K, Oyama T, Chikamatsu K. Prognostic significance and population dynamics of peripheral monocytes in patients with oropharyngeal squamous cell carcinoma. Head Neck 2019;41:1880-1888.

7.Chikamatsu K, Tada H, Takahashi H, Kuwabara-Yokobori Y, Ishii H, Ida S, Shino
M. Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma. Oral Oncol 2019;89:34-39.

8.Matsuyama T, Kawano M, Takagi R, Nakagome K, Chikamatsu K, Matsushita S. Interleukin-8 produced by T cells is under the control of dopamine signaling. Clin Exp Neuroimmunol 2018;9:251-257.

9.Sakamoto K, Fujita Y, Chikamatsu K, Tanaka S, Takeda S, Masuyama K, Yoshimura K, Ishii H. Ambient mass spectorometry-based detection system for tumor cells in human blood. Transl Cancer Res 2018;7:758-764.

10.Motokawa Y, Kokubo M, Kuwabara N, Tatematsu K, Sezutsu H, Takahashi H, Sakakura K, Chikamatsu K, Takeda S. Production of the MAGE-A4 protein using transgenic silkworms and induction of MAGE-A4-specific immune responses. Exp Ther Med 2018;15:2512-2518.

11.Ishii H, Chikamatsu K, Igarashi S, Takahashi H, Sakamoto K, Higuchi H, Tanaka S, Matsuoka T, Masuyama K. Establishment of Synergistic Chemoimmunotherapy for Head and Neck Cancer Using Peritumoral Immature Dendritic Cell Injections and Low-Dose Chemotherapies. Transl Oncol. 2017;11:132-139.

12.Shirai K, Fukata K, Adachi A, Saitoh JI, Musha A, Abe T, Kanai T, Kobayashi D, Shigeta Y, Yokoo S, Chikamatsu K, Ohno T, Nakano T. Dose-volume histogram analysis of brainstem necrosis in head and neck tumors treated using carbon-ion radiotherapy. Radiother Oncol 2017;125:36-40.

13.Shirai K, Saitoh JI, Musha A, Abe T, Kobayashi D, Takahashi T, Tamaki T, Kawamura H, Takayasu Y, Shino M, Toyoda M, Takahashi K, Hirato J, Yokoo S, Chikamatsu K, Ohno T, Nakano T. Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Cancer Sci. 2017;108:2039-2044.

14.KawadaT, Takahashi H, Sakakura K, Ida S, Mito I, Toyoda M, Chikamatsu K. Circulating tumor cells in patients with head and neck squamous cell carcinoma: Feasibility of detection and quantitation. Head Neck 2017;39:2180-2186.

15. Saitoh J, Shirai K, Imaeda M, Musha A, Abe T, Shino M, Takayasu Y, Takahashi K, Chikamatsu K, Nakano T. Concurrent chemoradiotherapy with conventional fractionated radiotherapy and low-dose daily cisplatin plus weekly docetaxel for T2NO glottic cancer. Radiat Oncol 2017;12:39.

16. Takahashi H, Sakakura K, Kudo T, Toyoda M, Kaira K, Oyama T, Chikamatsu K. Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages. Oncotarget 2017;8:8633-8647.

17. Shirai K, Saitoh JI, Musha A, Abe T, Kobayashi D, Takakusagi Y, Takaysu Y, Shino M, Toyoda M, Takahashi K, Chikamatsu K, Ohno T, Nakano T. Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer. Anticancer Res 2016;36:6571 6578.

18. Sakakura K, Tazawa M, Otani N, Takagi M, Morita M, Kurosaki M, Chiyoda T, Kanai Y, Endo A, Murata T, Shino M, Yokobori Y, Shirakura K, Wada N, Chikamatsu K. Impact of a multidisciplinary round visit for the management of dysphagia utilizing a Wi-Fi”based wireless flexible endoscopic evaluation of swallowing. Ann Otol Rhinol Laryngol 2017;126:47-53.

19. Okano Y, Satoh T, Hriguchi K, Toyoda M, Osaki A, Matsumoto S, Tomaru T, Nakajima Y, Ishii S, Ozawa A, Shibusawa N, Shimada T, Higuchi T, Chikamatsu K, Yamada M. Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma. Endocr J 2016;63:905-912.

20. Sakakura K, Takahashi H, Kaira K, Toyoda M, Murata T, Ohnishi H, Oyama T, Chikamatsu K. Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment. Lab Invest 2016;96:994 1003.

Top of Page


August, 1944; Establishment of the department of Oto-rhino-laryngology
September, 1944; Inauguration of professor Shintaro Kitagawa
April, 1957; Inauguration of professor Hideo Ishii
April, 1984; Inauguration of professor Tamio Kamei
July, 1998; Inauguration of professor Nobuhiko Furuya
September, 2011; Inauguration of professor Kazuaki Chikamatsu