Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Metabolic Regulation

Clinical Pharmacology and Therapeutics

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Professor Koujirou Yamamoto, Ph.D.
Associate Professor Takuya Araki, Ph.D.
Assistant Professor Tadahiro Hashita, Ph.D.


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Research & Education

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Clinical Activities

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Citizenship Activities

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1. Rusdiana T, Araki T, Nakamura T, Subarnas A, Yamamoto K: Responsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian population. European Journal of Clinical Pharmacology 69(3):395-405, 2013

2. Obayashi K, Araki T, Nakamura K, Kurabayashi M, Nojima Y, Hara K, Nakamura T, Yamamoto K: Risk of Falling and Hypnotic Drugs: Retrospective Study of Inpatients. Drugs in R&D 36(8):1068-77, 2013

3. Ohno I, Araki T, Kawano M, Nakamura T, Yamamoto K: Sensitive and simple determination of vitamin K1 in human plasma by ultra-performance liquid chromatography coupled with a fluorescence detector. Journal of liquid chromatography & related technologies 36(8):1068-77, 2103

4. Nagano D, Araki T, Nakamura T, Yamamoto K: Determination of Intracellular Darunavir by Liquid Chromatography Coupled with Fluorescence Detection. Journal of Chromatographic Science In press

5. Fujita Y, Araki T, Okada Y, Aomori T, Shimizu R, Tomizawa T, Hiromura K, Nojima Y, Nakamura T, Yamamoto K: Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents. Journal of Clinical Pharmacy and Therapeutics 38(1):74-6, 2013

6. Tomita H, Kadokami T, Momii H, Kawamura N, Yoshida M, Inou T, Fukuizumi Y, Usui M, Funakoshi K, Yamada S, Aomori T, Yamamoto K, Uno T, Ando S, On behalf of ATTACK-WF research group: Patient factors against stable control of warfarin therapy for Japanese non-valvular atrial fibrillation patients. Thrombosis Research 132(5):537-42, 2013

7. Hirooka-Masui K, Lesmana R, Iwasaki T, Xu M, Hayasaka K, Haraguchi M, Takeshita A, Shimokawa N, Yamamoto K, Koibuchi N: Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter. Life Sci 92(17-19):911-5, 2013

8. Akiyoshi T, Ito M, Murase S, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H: Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants: Drug Metabolism and Pharmacokinetics 28(5):411-5, 2013

9. Araki T, Takaai M, Miyazaki A, Ohshima S, Shibamiya T, Nakamura T, Yamamoto K: Clinical efficacy of two intravenous iron, saccharated ferric oxide and cideferron, for iron deficiency anemia. Pharmazie 67:1030-1032, 2012

10. Araki T, Yashima H, Shimizu K, Aomori T, Hashita T, Kaira K, Nakamura T, Yamamoto K: Review of the treatment of non-small-cell lung cancer with gefitinib. Clinical Medicine Insights: Oncology 6:407-421, 2012

11. Aomori T, Makino H, Sekizuka M, Araki T, Iizuka K, Nakamura T, Yamamoto K: Effect of ethanol contained in paclitaxel injection on the ethanol concentration in expiration. Drugs R&D 12(3):165-170, 2012

12. Hashita T, Katsuyama Y, Nakamura K, Momose Y, Komatsu D, Koide N, Miyagawa S, Nakamura T, Yamamoto K, Ohmori S: A patient with GIST modified dose by measurement of plasma concentration of sunitinib. Oncology Letters 4(3):501-504, 2012

13. Nagamine A, Takenaka M, Aomori T, Okada Y, Hiromura K, Nojima Y, Araki T, Nakamura T, Yamamoto K: Effect of genetic polymorphisms (TPMT, ITPA, IMPDH1, XO and MRP4) on the efficacy of low-dose azathioprine therapy in Japanese patients with systemic lupus erythematosus. Amer J Health-Sys Pharm 69(23):2072-2078, 2012

14. Nakamura K, Obayashi K, Araki T, Aomori T, Fujita Y, Okada Y, Kurabayashi M, Hasegawa A, Ohmori S, Nakamura T, Yamamoto K: CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects. J. Clin. Pharmacy Ther 37(4):481-485, 2012

15. Achmad A, Hanaoka H, Yoshioka H, Yamamoto S, Tominaga H, Araki T, Ohshima Y, Oriuchi N, Endo K: Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography. Cancer Science 103:600-605, 2012

16. Arisawa M, Kasaya Y, Obata T, Sasaki T, Nakamura T, Araki T, Yamamoto K, Sasaki A, Yamano A, Ito M, Abe H, Ito Y, Shuto S: Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multi-drug resistant protein without Cox inhibitory activity. J Med Chem 55(18):8152-8163, 2012

17. Ogawa T, Nakamura T, Araki T, Yamamoto K, Shuto S, Arisawa M: Ruthenium-catalyzed cycloisomerization of 1,3-dienes, for example, an N-dienyl-2-vinylaniline derivative, leading to a 3-Exomethylene-2-vinyl indole derivative and its application to the synthesis of (±)- cinchonaminone. Eur J Organic Chemistry 16:3084-3087, 2012

18. Matsumoto N, Aomori T, Kanamoto M, Usui T, Shiga T, Yamamoto K, Saito S: Influence of hemodynamic variations on the pharmacokinetics of landiolol in patients undergoing cardiovascular surgery. Biol Pharm Bull 35(10):1655-1660, 2012

19. Nagai Y, Tanaka Y, Nakazato Y, Sugawara N, Arai M, Okada E, Koyama Y, Hinohara H, Yamamoto K, Kurabayashi M, Nojima Y, Ishikawa O: Autopsy case of delayed anaphylactic shock due to contrast medium. J Dermatol 39:852?854, 2012

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