Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Metabolic Regulation

Anatomy and Cell Biology

We aim to elucidate the biological structure and function of the human body at the cell and molecular level.  We analyze the function and regulation of cell membrane proteins by using histochemical and biochemical techniques.  We also educate the medical students and graduate students in anatomy and cell biology.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History

Staffs

Professor Toshiyuki Matsuzaki (MD, PhD)  
Associate Professor    
Associate Professor Takeo Aoki (PhD)  

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Research & Education

Research content

We aim to elucidate the biological structure and function of the human body at the cell and molecular level.  We analyze the function and regulation of cell membrane proteins by using histochemical and biochemical techniques.  We focus on the water channel proteins, aquaporins.

Business education

teaching in graduate course

advices in experiments and thesis preparation

cell biology in basic medicine

tutorial courses

human gross anatomy (lectures, laboratory courses)

neuroanatomy (lectures, laboratory courses)

hisotology(lectures, laboratory courses)

general education

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Clinical Activities

(no clinical assignments)

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Citizenship Activities

We participate in the laboratory courses and workshops in electron microscopy for students from the elementary to high schools.

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Achievements

Matsuzaki T, Hata H, Ozawa H, Takata K. Immunohistochemical localization of the aquaporins AQP1, AQP3, AQP4, and AQP5 in the mouse respiratory system. Acta Histochem Cytochem 42: 159-169, 2009.

松崎利行,高田邦昭,小澤一史.腎臓と唾液腺における細胞膜水チャネル,アクアポリン.顕微鏡 44:111-116,2009.

Iida Y, Matsuzaki T, Morishima T, Sasano H, Asai K, Sobue K, Takata K. Localization of reversion-induced LIM protein (RIL) in the rat central nervous system. Acta Histochem Cytochem 42: 9-14, 2009.

Hagiwara H, Ohwada N, Aoki T, Suzuki T & Takata K : The primary cilia of
secretory cells in the human oviduct mucosa. Med Mol Molph 41: 193-198,
2009.

Hagiwara H, Ohwada N, Aoki T, Suzuki T & Takata K : Immunohistochemical and
electron microscopic observations of stromal cells in the human oviduct
mucosa. Med Mol Molph 41: 221-226, 2009.

Shiba D, Yamaoka Y, Hagiwara H, Takamatsu T, Hamada H &, Yokoyama T :
Localization of Inv in a distinctive intraciliary compartment requires the
C-terminal ninein-homolog-containing region. J Cell Sci. 122: 44-54, 2009.

Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang
Qi, Leblond G, O’Toole E, Hara C, Mizuno H, Kawano H, Fliegau M, Yagi T,
Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya
R, Mitchell DR & Takeda H: Ktu/PF13 is required for cytoplasmic pre-assembly
of axonemal dyneins. Nature 456: 611-616, 2008.

Takata K, Matsuzaki T, Tajika Y, Ablimit A & Hasegawa T : Localization and
trafficking of aquaporin 2 in the kidney. Histochem Cell Biol 130: 197-209,
2008.

Ablimit A, Aoki T, Matsuzaki T, Suzuki, Hagiwara H, Takami S & Takata K.
Immunolocalization of water channel aquaporins in the vomeronasal organ of
the rat. Expression of AQP4 in neuronal sensory cells. Chemical Senses 33:
481-488, 2008.

Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Puentes S., Aoki T.,
Hata H, Takata K, Yoshimoto Y & Saito N. Experimental model of lacunar
infarction in the gyrencephalic brain of the miniature pig: Neurological
assessment and histological, immunohistochemical, and physiological
evaluation of dynamic corticospinal tract deformation : Stroke 39: 205-213,
2008.

Suzuki T, Matsuzaki T, Hagiwara H, Aoki T & Takata K : Recent advance on
fluorescent labeling technique for fluorescence microscopy. Acta Histochem
Cytochem 40: 131-137, 2007.

Aoki T, Hagiwara H, Matsuzaki T, Suzuki T & Takata K : Internalization of
caveolae and their relationship with endosomes in cultured human and mouse
endothelial cells. Anat Sci Int, 82: 82-97, 2007.

Hasegawa T, Matsuzaki T, Tajika Y, Ablimit A, Suzuki T, Aoki T, Hagiwara H,
Takata K: Differential localization of aquaporin-2 and glucose transporter 4
in polarized MDCK cells. Histochem Cell Biol 127: 233-241, 2007.

Hagiwara H, Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Takata K: Localization
of Golgi 58K protein (formiminotransferase cyclodeaminase) to the
centrosome. Histochem Cell Biol 126, 251-259, 2006.

Ablimit A, Matsuzaki T, Tajika Y, Aoki T, Hagiwara H & Takata K:
Immunolocalization of water channel aquaporins in the nasal olfactory
mucosa. Arch Histol Cytol 69, 1-12, 2006.

Tajika Y, Matsuzaki T, Suzuki T, Ablimit A, Aoki T, Hagiwara H, Kuwahara M,
Sasaki S & Takata K: Differential regulation of AQP2 trafficking in
endosomes by microtubules and actin filaments. Histochem Cell Biol 124:
1-12, 2005.

Morishita Y, Matsuzaki T, Hara-Chikuma M, Andoo A, Shimono M, Matsuki A,
Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K,
Sasaki S & Ishibashi K: Disruption of aquaporin-11 produces polycystic
kidneys following vacuolization of the proximal tubule. Mol Cell Biol 25:
7770-7779, 2005.

Matsuzaki T, Machida N, Tajika Y, Ablimit A, Suzuki T, Aoki T, Hagiwara H &
Takata K: Expression and immunolocalization of water channel aquaporins in
the rat and mouse mammary gland. Histochem Cell Biol 123: 501-512, 2005.

Hagiwara H, Ohwada N, Takata K: Cell biology of normal and abnormal
ciliogenesis in the ciliated epithelium. Int Rev Cytol 234:101-141, 2004.

Takata K, Matsuzaki T & Tajika Y: Aquaporins: water channel proteins of the
cell membrane. Prog Histochem Cytochem 39: 1-83, 2004.

Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Hagiwara H, Kuwahara M, Sasaki S &
Takata K: Aquaporin-2 is retrieved to the apical storage compartment via
early endosomes and phosphatidylinositol 3-kinase-dependent pathway.
Endocrinology 145: 4375-4383, 2004.

Takeda S, Takahashi M, Mizukami H, Kobayashi E, Takeuchi K, Hakamata Y,
Kaneko T, Yamamoto H, Ito C, Ozawa K, Ishibashi K, Matsuzaki T, Takata K,
Asano Y & Kusano E: Successful gene transfer using adeno-associated virus
vectors into the kidney: Comparison among adeno-associated virus serotype
1-5 vectors in vitro and in vivo. Nephron Exp Nephrol 96: e119-e126, 2004.

Hayashi K, Kawai-Hirai R, Harada A & Takata K: Delayed axon formation by and
active migration of inhibitory neurons from fetal rat cerebral cortex in
vitro. J Cell Sci 116: 4419-4428, 2003.

Ishibashi K, Matsuzaki T, Takata K & Imai M: Identification of a new member
of type 1 Na/phosphate co-transporter in the rat kidney. Nephron Physiol 94:
10-18, 2003.

Hagiwara H & Takata K: Depolymerization of microtubules by colcemid induces
the formation of elongated and centriole-nonassociated striated rootlets in
PtK2 cells. Cell Tissue Res 309: 287-292, 2002.

Tajika Y, Mastuzaki T, Suzuki T, Aoki T, Hagiwara H,Tanaka S, Kominami E &
Takata K: Immunohistochemical characterization of the intracellular pool of
water channel aquaporin-2 in the rat kidney. Anat Sci Int 77: 189-195, 2002.

Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T &
Izumi T: The Rab 27a/granuphilin complex regulates the exocytosis of
insulin-containing dense-core granules. Mol Cell Biol 22: 1858-1867, 2002.

Hussar P, Tserentsoodol N, Koyama H, Yokoo-Sugawara M, Matsuzaki T, Takami S
& Takata K: Glucose transporter GLUT1 and tight junction protein occludin in
nasal olfactory mucosa. Chem Senses 27: 7-11, 2002.

Suzuki T, Fujikura K, Koyama H, Matsuzaki T, Takahashi Y & Takata K: The
apical localization of SGLT1 glucose transporter is determined by the short
amino acid sequence in its N-terminal domain. Eur J Cell Biol 80: 765-774,
2001.

Matsuzaki T, Suzuki T & Takata K: Hypertonicity-induced expression of
aquaporin 3 in MDCK cells. Am J Physiol 281: C55-C63, 2001.

Aoki T, Nomura R & Fujimoto T: Tyrosine phosphorylation of caveolin-1 in the
endothelium. Exp Cell Res: 253, 629-36, 1999.

Takata K, Hirano H & Kasahara H: Transport of glucose across the
blood-tissue barriers. Int Rev Cytol 172: 1-53, 1997.

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History

1943 Establishment of the Anatomy Department. Chairman: Prof.M. Niijima.
1947 Prof.M. Niijima moved to Tokyo Medical and Dental College and Prof. was superseded by Prof. Ito of the Tokyo Women’s Medical University.
1952 Anatomy Department was supplemented with the second anatomy department.
1960 N. Watari and A. Watanabe became the first graduate students to obtain Ph.D. in the Department of Anatomy.
1970 Dr.S.Shibasaki was appointed as a professor of the Department of Anatomy
1979 Prof. Emeritus T. Ito was awarded the Japan Academy Prize for his discovery and analysis of fat-storing cells (Ito cells).
1995 Dr.T.Fujimoto was appointed as a professor of the Department of Anatomy and Cell Biology after the retirement of Prof.Shibasaki.
2000 Prof.K.Takata moved from the Institute for Molecular and Cellular Regulation, Gunma University, and superseded Prof.Fujimoto who moved to Nagoya University.
2003 Department of Anatomy and Cell Biology became one of departments in the Subdivision of Metabolic Regulation, Gunma University Graduate School of Medicine by the reformation of the Medical School to Graduate School.