Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Basic Medical Sciences

Infectious Diseases and Host Defense

We are studying Virology and Parasitology and Immunology. In Virology, our research focuses on coronaviruses and studies the molecular biology and host cell-virus interaction of these coronaviruses. We also establish reverse genetics methods for coronaviruses and will extend our project to eradication of Infectious diseases. In Parasitology and immunology, we are focusing about a host-parasite interaction, especially about the protective immune response against malaria parasites and about allergy, autoimmunity, and anti-tumor immunity upon parasite infection.

  • Staff
  • Research & education
  • Clinical Activities
  • Citizen Activities
  • Achievement
  • History

Staffs

Professor Kamitani Wataru, Ph.D.
Associate Professor Suzue Kazutomo, Ph.D.
Assistant Professor Imai Takashi, Ph.D.

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Research & Education

Business education

We are in charge of giving lectures for undergraduate and graduate students. In relation to our research, as one of the pathogens and their pathogenesis are lectured in the systematized VIROLOGY and PARASITOLOGY lectures. We also give lectures host defense mechanisms against pathogens as IMMUNOLOGY, and both for the third grade undergraduate students. For graduate school students, we instruct how to conduct scientific experiments to encourage their research mind.

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Clinical Activities

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Citizenship Activities

We instruct general information of malaria and parasitic diseases to the medical officers of Ministry of Foreign Affairs and to medical experts from developing countries. Among our social contributions we devote to grow up young researchers from Thai, Uganda, India, Bangladesh and so on. Furthermore, we transfer our discovery concerning drugs and vaccines against protozoa or parasites to licensing or getting patents.

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Achievements

Virology:

1:  Molecular pharmacology of ciclesonide against SARS-CoV-2
Hirokazu Kimura, Hiromu Kurusu, Mitsuru Sada, Daisuke Kurai, Koichi Murakami, Wataru Kamitani, Haruyoshi Tomita, Kazuhiko Katayama, Akihide Ryo J Allergy Clin Immunol. 2020 Jun 13  doi: 10.1016/j.jaci.2020.05.029 [Epub ahead of print]
PMCID: PMC7293530

2:  Establishment of a Virulent Full-Length cDNA Clone for Type I Feline Coronavirus Strain C3663 Yutaka Terada, Yudai Kuroda, Shigeru Morikawa, Yoshiharu Matsuura, Ken Maeda, Wataru Kamitani J Virol. 2019 Nov 1; 93(21): e01208-19.  Prepublished online 2019 Aug 2. Published online 2019 Oct 15. doi: 10.1128/JVI.01208-19
PMCID: PMC6803248

3:  Development of fluorescent reverse transcription loop-mediated isothermal amplification (RT-LAMP) using quenching probes for the detection of the Middle East respiratory syndrome coronavirus Kazuya Shirato, Shohei Semba, Sherif A. El-Kafrawy, Ahmed M. Hassan, Ahmed M. Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar
J Virol Methods. 2018 Aug; 258: 41–48.  Published online 2018 May 12. doi: 10.1016/j.jviromet.2018.05.006
PMCID: PMC7113683

4:  MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA Yutaka Terada, Kengo Kawachi, Yoshiharu Matsuura, Wataru Kamitani Virology. 2017 Nov; 511: 95–105.  Published online 2017 Aug 23. doi: 10.1016/j.virol.2017.08.026
PMCID: PMC7118922

5:  Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication
Yusuke Sakai, Kengo Kawachi, Yutaka Terada, Hiroko Omori, Yoshiharu Matsuura, Wataru Kamitani Virology. 2017 Oct; 510: 165–174.  Published online 2017 Jul 21. doi: 10.1016/j.virol.2017.07.019
PMCID: PMC7111695

 

Parasitology:

1: CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.
Shimokawa C, Kato T, Takeuchi T, Ohshima N, Furuki T, Ohtsu Y, Suzue K, Imai T, Obi S, Olia A, Izumi T, Sakurai M, Arakawa H, Ohno H, Hisaeda H. Nat Commun. 2020 Apr 22;11(1):1922. doi: 10.1038/s41467-020-15857-x.

2: IL-33 is essential to prevent high fat diet-induced obesity in mice infected with an intestinal helminth. Obi S, Shimokawa C, Katsuura M, Olia A, Imai T, Suzue K, Hisaeda H.
Parasite Immunol. 2020 Feb 6:e12700. doi: 10.1111/pim.12700. Online ahead of print.
PMID: 32027755

3: Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma. Olia A, Shimokawa C, Imai T, Suzue K, Hisaeda H.
Parasitol Int. 2020 Jun;76:102057. doi: 10.1016/j.parint.2020.102057. Epub 2020 Jan 16.
PMID: 31954872

4: Chemotaxis Assay for Marsupenaeus japonicas Hemocytes and Application for the Development of an Oral Immunostimulant Against White Spot Syndrome Virus.
Imai T, Takahashi Y. Front Cell Dev Biol. 2020 Feb 7;8:46. doi: 10.3389/fcell.2020.00046. eCollection 2020.
PMID: 32117975 Free PMC article.

5: A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages. Marin-Mogollon C, Salman AM, Koolen KMJ, Bolscher JM, van Pul FJA, Miyazaki S, Imai T, Othman AS, Ramesar J, van Gemert GJ, Kroeze H, Chevalley-Maurel S, Franke-Fayard B, Sauerwein RW, Hill AVS, Dechering KJ, Janse CJ, Khan SM. Front Cell Infect Microbiol. 2019 Apr 16;9:96. doi: 10.3389/fcimb.2019.00096. eCollection 2019. PMID: 31058097 Free PMC article.

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History

○History of Dep. of Virology

1984 Dr. Hiroo Hosino became the sixth professor and He started research for Virology (HIV)
2012 Dr. Hiroki ISOMURA became the seventh professor

○History of Dep. of Parasitology

1996 Department of Parasitology was separated from Department of Hygiene, Dr. Toshisada SAWADA became the first professor.
1976 Dr. Mamoru SUZUKI became the second professor.
2004 Dr. Tomoyoshi NOZAKI became the third professor.
2010 Dr. Hajime HISAEDA became the fourth professor.

○History of Dep. Infectious Diseases and Host Defense

2019 Dr. Wataru Kamitani became professor and He started research for Coronavirus.