Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Biological Regulation

Integrative Physiology

We energetically study the effect of environmental factors on development and functional maintenance of organ system, particularly on those mediated by steroid/thyroid hormones.  The final goal of our research is to understand the whole view of such system (from molecule to behavior).  For this purpose, we use various research technique, such as behavioral analysis, histochemistry, cellular and molecular biological techniques, and biochemical technique. In addition to faculty staff and postgraduate students, we have many MD-PhD course students and undergraduates who actively involved in research projects in our laboratory.

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  • Research & education
  • Clinical Activities
  • Citizen Activities
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Professor Noriyuki Koibuchi, M.D., Ph.D.
Associate Professor Wataru Miyazaki, M.D., Ph.D.
Assistant Professor Sumiyasu Ishii, M.D., Ph.D.
Assistant Professor Asahi Haijima, Ph.D.
Assistant Professor Izuki Amano, M.D., Ph.D.

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Research & Education

Research content

Using integrative approach, we study the effect of environmental factors on brain development and organ metabolism.  Particularly, we are interested in the involvement of steroid/thyroid hormone system.  Using both in vivo and in vitro technique, following projects are ongoing;
1) Analysis of trophic and hormonal regulation on brain development
2) Involvement of endocrine-disrupting chemicals on trophic factor-mediated brain development.
3) The role of hormones and trophic factors on functional maintenance and adaptation of various organs.

Business education

To undergraduates, we take in charge of Physiology course with Neurophysiology Department.  We also give lectures of Introductory Biology to 1st year medical students, who have not taken Biology at high school, and Advanced Biology to 2nd year medical students.  In addition, we accept students for Research Presentation Tutorial for 1st year and Research Rotation for 3rd year of medical school.  Furthermore, we also take care of Pathophysiology Lecture Course with other departments.
To postgraduates, we take part in Organ Regulation lecture course.

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Clinical Activities

(no clinical assignments)

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Citizenship Activities

1. Through collaboration with the Board of Education, Gunma Prefecture, we conducted a lecture about the heat stroke for a health and physical education teacher and sports leader.  Also, we made a poster of the heat stroke prevention with the Baord and Prefectural Medical Association.
2. We participated in a Super Science High School program, invited a student to this school and conducted a scientific lecture and training.
3. We participated in a World brain Awareness Week program, gave a lecture of the neurosciences to high school students, and conducted simple experiment guidance.
4. We participated in a program of Japan Society for the Promotion of Science HIRAMEKI☆TOKIMEKI science program KAKENHI, and gave a lecture to middle school students, and conducted simple experiment guidance.

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1. Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N. Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism. J Neuroendocrinol. 2014 Mar;26(3):164-75.

2. Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N.  Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder. Physiol Rep. 2014 Jan 13;2(1):e00197.

3. Xu M, Iwasaki T, Shimokawa N, Sajdel-Sulkowska EM, Koibuchi N. The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 iodothyronine deiodinase activity in astrocytes.  Endocr J. 2013 Nov 29;60(11):1221-30.

4. Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T.  Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.  J Neurochem. 2013 Oct 13.

5. Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM.  Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain; modeling the effect of maternal infection on the developing human CNS. Cerebellum. 2013 Aug;12(4):572-86.

6. Takatsuru Y, Nabekura J, Koibuchi N. Contribution of neuronal and glial circuit in intact hemisphere for functional remodeling after focal ischemia. Neurosci Res. 2013 Jul 26.

7. Xu M, Sajdel-Sulkowska EM, Iwasaki T, Koibuchi N. Aberrant cerebellar neurotrophin-3 expression induced by lipopolysaccharide exposure during brain development. Cerebellum. 2013 Jun;12(3):316-8.

8. Koibuchi N. The role of thyroid hormone on functional organization in the cerebellum. Cerebellum. 2013 Jun;12(3):304-6.

9. Takatsuru Y, Nabekura J, Koibuchi N. Activity of the layer II/III neurons in the somatosensory cortex (SSC) plays a critical role on functional recovery after focal stroke in the contralateral SSC. Neurosci Lett. 2013 May 24;543:168-71.

10. Hirooka-Masui K, Lesmana R, Iwasaki T, Xu M, Hayasaka K, Haraguchi M, Takeshita A, Shimokawa N, Yamamoto K, Koibuchi N.  Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter. Life Sci. 2013 May 20;92(17-19):911-5.

11. Takatsuru Y, Eto K, Kaneko R, Masuda H, Koibuchi N, Nabekura J. Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke. (NK & JN equal contribution) J Neurosci. 2013 Mar 13;33(11):4683-92.

12. Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM. Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS. Cerebellum. 2013 Mar 9.

13. Xu M, Sajdel-Sulkowska EM, Iwasaki T, Koibuchi N. Aberrant cerebellar neurotrophin-3 expression induced by lipopolysaccharide exposure during brain development. Cerebellum. 2013 Jun;12(3):316-8.

14. Lesmana R, Shimokawa N, Takatsuru Y, Iwasaki T, Koibuchi N. Lactational exposure to hydroxylated polychlorinated biphenyls (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor Environ ToxicolEnviron Toxicol. 2012 Sep 20.

15. Itoh M, Shimokawa N, Tajika Y, Murakami T, Aotsuka N, Lesmana R, Farenia R, Iwasaki T, Okada J, Yorifuji H, Koibuchi N. Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion. Mol Cell Biochem 373: 11-18, 2013

16. Xiong Y, Ibhazehiebo K, Iwasaki T, Koibuchi N. An in vitro method to study the effects of thyroid hormone-disrupting chemicals on neuronal development. Neurotoxicology 33: 753-757, 2012

17. Takeshita A, Igarashi-Migitaka J, Nishiyama K, Takahashi H, Takeuchi Y, Koibuchi N. Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome P450 3A through steroid and xenobiotic receptor. Toxicol Sci 123(2): 460?470, 2011

18. Takatsuru Y, Koibuchi N, Nabekura J.  Unilateral infarction of the visual cortex (VC) induced an increase in dendritic spine turnover in contrallateral VC.  Neurosci Lett 488: 97-100, 2011

19. Ibhazehiebo K, Iwasaki T, Kimura-Kuroda J, Miyazaki W, Shimokawa N, Koibuchi N. Disruption of thyroid hormone receptor-mediated transcription and thyroid hormone-induced Purkinje cell dendrite arborization by polybrominated diphenyl ethers.  Env Health Perspect 119: 168-175, 2011

20. Shimokawa N, Haglund K, Holter SM, Grabbe C, Kirkin V, Koibuchi N, Schulz C, Rozman J, Hoeller D, Qiu CH, Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.  CIN85 regulates dopamine receptor endocytosis and governs behavior in mice.  EMBO J 29: 2421-2432, 2010

21. Qiu CH, Miyazaki W, Iwasaki T, Londono M, Ibhazehiebo K, Shimokawa N, Koibuchi N. Retinoic acid receptor-related orphan receptor alpha-enhanced thyroid hormone receptor-mediated transcription requires its ligand binding domain which is not, by itself, sufficient: possible direct interaction of two receptors.  Thyroid19: 893-898, 2009

22. Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoishi I, Koibuchi N. Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR)α in breast cancer cells: Identification of a novel ROR response element. J Biol Chem 284: 17711-17719, 2009

23. Miyazaki W, Iwasaki T, Takeshita A, Tohyama C, Koibuchi N.    Identification of the functional domain of thyroid hormone receptor responsible for polychlorinated biphenyl-mediated suppression of its action in vitro.  Environ Health Perspect 116: 1231-1236, 2008.

24. Qiu CH, Shimokawa N, Iwasaki T, Parhar IS, Koibuchi N. Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation. Endocrinology. 2007 Apr;148(4):1745-53.

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In May 1943, the department was started as Department of Physiology at Maebashi Medical Technical School.  Professor Yasuo Oku became the first chair of the department.  However, he was arrested into custody for a political creed.  He returned to his post after the war, and ran for a representative. However, he lost and resigned subsequently.
In October 1945, Professor Masao Matsumoto took up his new post as the chair from Tokyo Medicine Dentistry Technical School (existing Tokyo Medical and Dental University).  He served as the chairman until March, 1974.
In 1948, the department was reorganized to Department of Physiology, Maebashi Medical College. Furthermore, in 1950, it was reorganized to Department of Physiology, Gunma University School of Medicine. Then Department of Physiology was divided in to the 2 departments. Professor Matsumoto served as a chair of First Department of Physiology, where he established a model system to study neuronal excitable membrane using the non-biological material. The department made a great number of research achievements.
In April 1974, Professor Mitsuhiko Miura took up his new post from Chiba University School of Medicine. He served as the chairman until March, 1999.  Professor Miura studied neuronal mechanism regulating cardiovascular and respiratory system, using electrophysiology, morphology, molecular biology and various additional kinds of technique, and became the first person of this field.
In April 2001, Professor Noriyuki Koibuchi, who is a graduate of Gunma University School of Medicine 1985, took up his new post from Dokkyo University School of Medicine.  He serves as the chairman until now. He changed the research theme of the Department to Environmental Physiology.
The School of Medicine was reorganized to Gunma University School of Medicine in April, 2003. And the department of was renamed to Department of Integrative Physiology.  The department conducts medical education, and tries to contribute to society positively.