Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Biological Regulation

Integrative Physiology

We energetically study the effect of environmental factors on development and functional maintenance of organ system, particularly on those mediated by steroid/thyroid hormones.  The final goal of our research is to understand the whole view of such system (from molecule to behavior).  For this purpose, we use various research technique, such as behavioral analysis, histochemistry, cellular and molecular biological techniques, and biochemical technique. In addition to faculty staff and postgraduate students, we have many MD-PhD course students and undergraduates who actively involved in research projects in our laboratory.

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Professor Koibuchi Noriyuki, M.D., Ph.D.
Associate Professor Ishii Sumiyasu, M.D., Ph.D.
Amano Izuki, M.D., Ph.D.
Assistant Professor Fujiwara Yuki, Ph.D.

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Research & Education

Research content

Using integrative approach, we study the effect of environmental factors on brain development and organ metabolism.  Particularly, we are interested in the involvement of steroid/thyroid hormone system.  Using both in vivo and in vitro technique, following projects are ongoing;
1) Analysis of trophic and hormonal regulation on brain development
2) Involvement of endocrine-disrupting chemicals on trophic factor-mediated brain development.
3) The role of hormones and trophic factors on functional maintenance and adaptation of various organs.

Business education

To undergraduates, we take in charge of Physiology course with Neurophysiology Department.  We also give lectures of Introductory Biology to 1st year medical students, who have not taken Biology at high school, and Advanced Biology to 2nd year medical students.  In addition, we accept students for Research Presentation Tutorial for 1st year and Research Rotation for 3rd year of medical school.  Furthermore, we also take care of Pathophysiology Lecture Course with other departments.
To postgraduates, we take part in Organ Regulation lecture course.

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Clinical Activities

(no clinical assignments)

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Citizenship Activities

1. Through collaboration with the Board of Education, Gunma Prefecture, we conducted a lecture about the heat stroke for a health and physical education teacher and sports leader.  Also, we made a poster of the heat stroke prevention with the Baord and Prefectural Medical Association.
2. We participated in a Super Science High School program, invited a student to this school and conducted a scientific lecture and training.
3. We participated in a World brain Awareness Week program, gave a lecture of the neurosciences to high school students, and conducted simple experiment guidance.
4. We participated in a program of Japan Society for the Promotion of Science HIRAMEKI☆TOKIMEKI science program KAKENHI, and gave a lecture to middle school students, and conducted simple experiment guidance.

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1: Sato T, Vargas D, Miyazaki K, Uchida K, Ariyani W, Miyazaki M, Okada J, Lizcano F, Koibuchi N, Shimokawa N. EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes. J Cell Physiol. 2020 Feb 13. doi: 10.1002/jcp.29567. Epub ahead of print. PMID: 32056205.

2: Ishii S, Yamada M, Koibuchi N. Chicken ovalbumin upstream promoter- transcription factor II protects against cisplatin-induced acute kidney injury. Endocr J. 2020 Mar 28;67(3):283-293. doi: 10.1507/endocrj.EJ19-0459. Epub 2019 Dec 3. PMID: 31801919.

3: Ariyani W, Miyazaki W, Koibuchi N. A Novel Mechanism of S-equol Action in Neurons and Astrocytes: The Possible Involvement of GPR30/GPER1. Int J Mol Sci. 2019 Oct 18;20(20):5178. doi: 10.3390/ijms20205178. PMID: 31635400; PMCID: PMC6829462.

4: Hashimoto S, Ichinose T, Ohsawa T, Koibuchi N, Chikuda H. Extracorporeal Shockwave Therapy Accelerates the Healing of a Meniscal Tear in the Avascular Region in a Rat Model. Am J Sports Med. 2019 Oct;47(12):2937-2944. doi: 10.1177/0363546519871059. Epub 2019 Sep 10. PMID: 31503505.

5: Farenia R, Lesmana R, Uchida K, Iwasaki T, Koibuchi N, Shimokawa N. Changes in biomarker levels and myofiber constitution in rat soleus muscle at different exercise intensities. Mol Cell Biochem. 2019 Aug;458(1-2):79-87. doi: 10.1007/s11010-019-03532-9. Epub 2019 Apr 16. PMID: 30993497.

6: Khairinisa MA, Takatsuru Y, Amano I, Kokubo M, Haijima A, Miyazaki W, Koibuchi N. In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice. Front Endocrinol (Lausanne). 2018 May 14;9:228. doi: 10.3389/fendo.2018.00228. PMID: 29867761; PMCID: PMC5960672.

7: Ariyani W, Iwasaki T, Miyazaki W, Yu L, Takeda S, Koibuchi N. A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription. Toxicol Sci. 2018 Aug 1;164(2):417-427. doi: 10.1093/toxsci/kfy097. PMID: 29688519.

8: Amano I, Takatsuru Y, Khairinisa MA, Kokubo M, Haijima A, Koibuchi N. Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring. Endocrinology. 2018 Apr 1;159(4):1910-1921. doi: 10.1210/en.2017-03125. PMID: 29522169.

9: Fujiwara Y, Miyazaki W, Koibuchi N, Katoh T. The Effects of Low-Dose Bisphenol A and Bisphenol F on Neural Differentiation of a Fetal Brain-Derived Neural Progenitor Cell Line. Front Endocrinol (Lausanne). 2018 Feb 9;9:24. doi: 10.3389/fendo.2018.00024. PMID: 29479338; PMCID: PMC5811521.

10: Ariyani W, Khairinisa MA, Perrotta G, Manto M, Koibuchi N. The Effects of Gadolinium-Based Contrast Agents on the Cerebellum: from Basic Research to Neurological Practice and from Pregnancy to Adulthood. Cerebellum. 2018 Jun;17(3):247-251. doi: 10.1007/s12311-017-0903-4. PMID: 29196974.

11: Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N. Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13042-13047. doi: 10.1073/pnas.1621196114. Epub 2017 Nov 20. PMID: 29158391; PMCID: PMC5724246.

12: Khairinisa MA, Takatsuru Y, Amano I, Erdene K, Nakajima T, Kameo S, Koyama H, Tsushima Y, Koibuchi N. The Effect of Perinatal Gadolinium-Based Contrast Agents on Adult Mice Behavior. Invest Radiol. 2018 Feb;53(2):110-118. doi: 10.1097/RLI.0000000000000417. PMID: 28915162.

13: Haijima A, Lesmana R, Shimokawa N, Amano I, Takatsuru Y, Koibuchi N. Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice. J Toxicol Sci. 2017;42(4):407-416. doi: 10.2131/jts.42.407. PMID: 28717099.

14: Ariyani W, Iwasaki T, Miyazaki W, Khongorzul E, Nakajima T, Kameo S, Koyama H, Tsushima Y, Koibuchi N. Effects of Gadolinium-Based Contrast Agents on Thyroid Hormone Receptor Action and Thyroid Hormone-Induced Cerebellar Purkinje Cell Morphogenesis. Front Endocrinol (Lausanne). 2016 Aug 26;7:115. doi: 10.3389/fendo.2016.00115. PMID: 27617003; PMCID: PMC4999949.

15: Amano I, Takatsuru Y, Toya S, Haijima A, Iwasaki T, Grasberger H, Refetoff S, Koibuchi N. Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors. Thyroid. 2016 May;26(5):741-52. doi: 10.1089/thy.2015.0034. Epub 2016 Mar 23. PMID: 26914863; PMCID: PMC4860669.

16: Khairinisa MA, Amano I, Miyazaki W, Koibuchi N, Tsushima Y. Gadolinium-based contrast agents toxicity in animal studies. Magn Reson Imaging. 2019 Oct;62:57-58. doi: 10.1016/j.mri.2019.05.027. Epub 2019 May 30. PMID: 31153911.

17: Sonoda H, Iizuka H, Ishiwata S, Tsunoda D, Abe M, Takagishi K, Chikuda H, Koibuchi N, Shimokawa N. The retinol-retinoic acid metabolic pathway is impaired in the lumbar spine of a rat model of congenital kyphoscoliosis. J Cell Biochem. 2019 Sep;120(9):15007-15017. doi: 10.1002/jcb.28762. Epub 2019 May 5. PMID: 31056772.

18: Kaneko R, Takatsuru Y, Morita A, Amano I, Haijima A, Imayoshi I, Tamamaki N, Koibuchi N, Watanabe M, Yanagawa Y. Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites. J Comp Neurol. 2018 Feb 15;526(3):373-396. doi: 10.1002/cne.24343. Epub 2017 Nov 11. PMID: 29063602.

19: Erdene K, Nakajima T, Kameo S, Khairinisa MA, Lamid-Ochir O, Tumenjargal A, Koibuchi N, Koyama H, Tsushima Y. Organ retention of gadolinium in mother and pup mice: effect of pregnancy and type of gadolinium-based contrast agents. Jpn J Radiol. 2017 Oct;35(10):568-573. doi: 10.1007/s11604-017-0667-2. Epub 2017 Jul 20. PMID: 28730467.

20: Tsunoda D, Iizuka H, Ichinose T, Iizuka Y, Mieda T, Shimokawa N, Takagishi K, Koibuchi N. The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis. Mol Cell Biochem. 2016 Jan;412(1-2):11-8. doi: 10.1007/s11010-015-2603-z. Epub 2015 Nov 7. PMID: 26547552.

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In May 1943, the department was started as Department of Physiology at Maebashi Medical Technical School.  Professor Yasuo Oku became the first chair of the department.  However, he was arrested into custody for a political creed.  He returned to his post after the war, and ran for a representative. However, he lost and resigned subsequently.
In October 1945, Professor Masao Matsumoto took up his new post as the chair from Tokyo Medicine Dentistry Technical School (existing Tokyo Medical and Dental University).  He served as the chairman until March, 1974.
In 1948, the department was reorganized to Department of Physiology, Maebashi Medical College. Furthermore, in 1950, it was reorganized to Department of Physiology, Gunma University School of Medicine. Then Department of Physiology was divided in to the 2 departments. Professor Matsumoto served as a chair of First Department of Physiology, where he established a model system to study neuronal excitable membrane using the non-biological material. The department made a great number of research achievements.
In April 1974, Professor Mitsuhiko Miura took up his new post from Chiba University School of Medicine. He served as the chairman until March, 1999.  Professor Miura studied neuronal mechanism regulating cardiovascular and respiratory system, using electrophysiology, morphology, molecular biology and various additional kinds of technique, and became the first person of this field.
In April 2001, Professor Noriyuki Koibuchi, who is a graduate of Gunma University School of Medicine 1985, took up his new post from Dokkyo University School of Medicine.  He serves as the chairman until now. He changed the research theme of the Department to Environmental Physiology.
The School of Medicine was reorganized to Gunma University School of Medicine in April, 2003. And the department of was renamed to Department of Integrative Physiology.  The department conducts medical education, and tries to contribute to society positively.