Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Basic Medical Sciences


Our research goal is to elucidate the following molecular mechanisms:
(1) Hypoxic response
(2) Lipid metabolism
(3) DNA damage response
(4) Cancer-specific metabolism
(5) Cellular senescence
Our experimental strategy includes biochemistry, molecular biology, cell biology, analytical chemistry, and genetics (mouse and fly).

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Professor Yoji Andrew Minamishima, M.D., Ph.D.
Professor Emeritus Takashi Izumi, M.D., Ph.D.
Associate Professor Kazuaki Tatei, Ph.D.
Hideru Obinata, Ph.D.
Akimitsu Konishi, M,D., Ph.D.
Assiatant Professor Noriyasu Ohshima, Ph.D.
Kazuki Irie, Ph.D.
Grad Students Binderiya Tserendavga, M.D.
Yuma Aramaki
Xian Zhao, PhC
Keisuke Kiyozuka, PhC.
Naoki Inoue, M.D.

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Research & Education

Research content

  1. (1) Regulation of cellular energy metabolism by the hypoxic response

The hypoxic response is involved in many physiological events, including metabolism, epigenetics, transcription, respiration, and redox. These are closely related to ischemia/reperfusion injury, ischemic heart disease, chronic kidney disease, obesity, cancer, and inflammation. Our lab is trying to elucidate the mechanism of metabolism regulation by the hypoxic response in vivo.

  1. (2) Regulation of lipid metabolism

Bioactive lipids are produced from membrane phospholipids upon various stimuli and act on their specific cell-surface receptors (G-protein coupled receptor; GPCR) of neighborhood cells. They are involved in most life activities such as nervous system, respiration, circulation, reproduction, and cell differentiation. In our department, biochemical research on phospholipid metabolism and lipid mediator is conducted. Our research project aims to clarify the turnover of cell membrane phospholipids on various kinds of stimulation, production of bioactive lipids (leukotriene, LPA, 2-AG, 9-HODE), signal transduction through their GPCRs, and function of these bioactive lipids.

  1. (3) Response upon DNA damage

Our lab focuses on the maintenance of telomere and response upon DNA damage, trying to unveil the whole molecular mechanism of DNA-damage/DNA-repair signaling using the techniques including molecular biology, biochemistry, and proteomics using mass spectrometry.

  1. (4) Cancer cell-specific metabolism

We have already identified the several metabolites that might be involved in the cancer cell-specific energy metabolism system. Our goal is to develop a new treatment strategy against cancer that targets the cancer-specific metabolism pathway.

  1. (5) Molecular mechanism of cellular senescence

B Based on our preliminary metabolome analysis, we have identified several cellular senescence-specific metabolites. The project aims to clarify the whole picture of cellular senescence form the view of cellular metabolism.

The hypoxic response, Lipid mediator, Receptor, Signal transduction, DNA damage, Omics analysis

For detail, visit our web site.

Business education

[for the undergrad students]
Organic Chemistry (1st grade)
Basic Genetics (2nd grade)
Biochemistry (2nd grade)

[for the grad students]
Lecture of Biochemistry, Exercise of Biochemistry, Practice of Biochemistry. For detail, visit our web site.

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Clinical Activities

(no clinical assignments)

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Citizenship Activities

(1) International Brain Awareness Week

(2) Gunma Chibikko University

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Please check PubMed for the latest publications.

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Former professors and main research projects

1st: Dr. Yoshio Mutoh (1943-1949)
Chemistry, Biochemistry, Mathematics, Physics

2nd: Dr. Saburo Yamazoe (1949-1974)
Fatigue, Phospholipid of Muscle and Brain, Metabolism in Sperm

3rd: Dr. Satoshi Yamashita (1974-2000)
Metabolism of Phospholipid, Phospholipase D & C, Choline kinase

4th: Dr. Takashi Izumi (2000-2018)
Lipid mediator, Metabolism of Phospholipid, GPCR

5th: Yoji Andrew Minamishima (2018~)
Hypoxic response, metabolism, cancer biology, and cellular senescence