Graduate School of Medicine / School of Medicine, Faculty of Medicine

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Basic Medical Sciences


Bioactive lipids are produced from membrane phospholipids upon various stimuli, and act on their specific cell-surface receptors (G-protein coupled receptor; GPCR) of neighborhood cells. They are involved in most life activity such as nervous system, respiration, circulation, reproduction, and cell differentiation. In our department, biochemical research on phospholipid metabolism and lipid mediator is conducted.

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Professor Yoji Andrew Minamishima, M.D., Ph.D.
Professor Emeritus Takashi Izumi, M.D., Ph.D.
Associate Professor Kazuaki Tatei, Ph.D.
Associate Professor Akimitsu Konishi, M,D., Ph.D.
Assiatant Professor Noriyasu Ohshima, Ph.D.
Hiraku Suzuki, Ph.D.

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Research & Education

Research content

Our research projects aim to clarify turnover of cell membrane phospholipids on various kinds of stimulation, production of bioactive lipids (leukotriene, LPA, 2-AG, 9-HODE), signal transduction through their GPCRs, and function of these bioactive lipids. We are also interested in DNA-damage induced signaling, and function of telomere.

Business education

Organic Chemistry (1st grade)
Basic Genetics (2nd grade)
Biochemistry (2nd grade)

Lecture of Biochemistry, Exercise of Biochemistry, Practice of Biochemistry

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Clinical Activities

(no clinical assignments)

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Citizenship Activities

International Brain Awareness Week

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GDE5 Inhibition Accumulates Intracellular Glycerophosphocholine and Suppresses Adipogenesis at a Mitotic Clonal Expansion Stage.
Okazaki Y, Nakamura K, Takeda S, Yoshizawa I, Yoshida F, Ohshima N, Izumi T, Klein JD, Kumrungsee T, Sands JM, Yanaka N.
Am J Physiol Cell Physiol. 2018

Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.
Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E.
Kidney Int. 2018 Nov 13. pii: S0085-2538(18)30635-5.

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure.
Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Sci Rep. 2018 Aug 13;8(1):12035.

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice.
Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Cardiovasc Res. 2018 Jul 1;114(8):1132-1144.

Inhibition of Phosphorylated c-Jun NH(2)-terminal Kinase by 2′,4′-dihydroxy-6-methoxy-3,5-dimethylchalcone Isolated from Eugenia aquea Burm f. Leaves in Jurkat T-cells.
Barliana MI, Diantini A, Subarnas A, Abdulah R, Izumi T.
Pharmacogn Mag. 2017 Oct;13(Suppl 3):S573-S577.

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.
Umbarawan Y, Syamsunarno MRAA, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.
Metabolism. 2017 Dec;77:47-57.

Metabolic activity by 18F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC.
Kaira K, Higuchi T, Naruse I, Arisaka Y, Tokue A, Altan B, Suda S, Mogi A, Shimizu K, Sunaga N, Hisada T, Kitano S, Obinata H, Yokobori T, Mori K, Nishiyama M, Tsushima Y, Asao T.
Eur J Nucl Med Mol Imaging. 2018 Jan;45(1):56-66.

An engineered S1P chaperone attenuates hypertension and ischemic injury.
Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T.
Sci Signal. 2017 Aug 15;10(492). pii: eaal2722.

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA.
Mol Cell Biol. 2017 Jul 28;37(16). pii: e00248-17.

Autophagy controls centrosome number by degrading Cep63.
Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.
Nat Commun. 2016 Nov 21;7:13508.

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.
Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, Itoh H.
Sci Rep. 2016 Nov 9;6:36533.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.
Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlén P, Suematsu M, Oya M.
JCI Insight. 2016 Nov 3;1(18):e83654.

Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase.
Araki M, Ohshima N, Aso C, Konishi A, Obinata H, Tatei K, Izumi T.
J Biochem. 2016 Nov;160(5):269-279.

TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.
Konishi A, Izumi T, Shimizu S.
J Biol Chem. 2016 Sep 23;291(39):20798-810.

Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C.
FASEB J. 2016 Jun;30(6):2351-9.

Protein purification and cloning of diacylglycerol lipase from rat brain.
Aso C, Araki M, Ohshima N, Tatei K, Hirano T, Obinata H, Kishi M, Kishimoto K, Konishi A, Goto F, Sugimoto H, Izumi T.
J Biochem. 2016 Jun;159(6):585-97.

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.
Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr, Suematsu M, Minamishima YA.
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11642-7.

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.
Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A.
Nat Med. 2015 Sep;21(9):1028-1037.

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.
Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T.
Sci Signal. 2015 Aug 11;8(389):ra79. doi: 10.1126/scisignal.aaa2581. Erratum in: Sci Signal. 2015 Oct 27;8(400):er8.

New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.
Ohshima N, Kudo T, Yamashita Y, Mariggiò S, Araki M, Honda A, Nagano T, Isaji C, Kato N, Corda D, Izumi T, Yanaka N.
J Biol Chem. 2015 Feb 13;290(7):4260-71.

Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type.
Yoshiyama S, Chen Z, Okagaki T, Kohama K, Nasu-Kawaharada R, Izumi T, Ohshima N, Nagai T, Nakamura A.
Atherosclerosis. 2014 Dec;237(2):464-70.

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.
Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T.
J Lipid Res. 2014 Dec;55(12):2665-75.

Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity.
Kikuchi D, Minamishima YA, Nakayama K.
Biochem Biophys Res Commun. 2014 Aug 22;451(2):288-94.

Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis.
Xi X, Tatei K, Kihara Y, Izumi T.
Gene Expr Patterns. 2014 Jul;15(2):88-95.

Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies.
Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T, Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y.
Biochim Biophys Acta. 2014 Jun;1840(6):1625-33.

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo.
Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
Mol Cancer Res. 2013 Sep;11(9):973-85.

Fine-tuning S1P therapeutics.
Obinata H, Hla T.
Chem Biol. 2012 Sep 21;19(9):1080-2.

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T.
Dev Cell. 2012 Sep 11;23(3):600-10.

Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.
Obinata H, Hla T.
Methods Mol Biol. 2012;874:69-76.

Involvement of Beclin 1 in engulfment of apoptotic cells.
Konishi A, Arakawa S, Yue Z, Shimizu S.
J Biol Chem. 2012 Apr 20;287(17):13919-29.

Sphingosine 1-phosphate in coagulation and inflammation.
Obinata H, Hla T.
Semin Immunopathol. 2012 Jan;34(1):73-91.

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q.
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13379-86.

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8.

Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr.
Circulation. 2010 Sep 7;122(10):1004-16.

Reactivation of hepatic EPO synthesis in mice after PHD loss.
Minamishima YA, Kaelin WG Jr.
Science. 2010 Jul 23;329(5990):407.

Detection of G protein-coupled receptor-mediated cellular response involved in cytoskeletal rearrangement using surface plasmon resonance.
Chen K, Obinata H, Izumi T.
Biosens Bioelectron. 2010 Mar 15;25(7):1675-80.

Identification and analysis of two splice variants of human G2A generated by alternative splicing.
Ogawa A, Obinata H, Hattori T, Kishi M, Tatei K, Ishikawa O, Izumi T.
J Pharmacol Exp Ther. 2010 Feb;332(2):469-78.

Osteoblast differentiation is functionally associated with decreased AMP kinase activity.
Kasai T, Bandow K, Suzuki H, Chiba N, Kakimoto K, Ohnishi T, Kawamoto S, Nagaoka E, Matsuguchi T.
J Cell Physiol. 2009 Dec;221(3):740-9.

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr.
Mol Cell Biol. 2009 Nov;29(21):5729-41.

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.
Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F.
Circulation. 2009 Sep 8;120(10):888-96.

Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.
Hirano T, Kishi M, Sugimoto H, Taguchi R, Obinata H, Ohshima N, Tatei K, Izumi T.
Biochim Biophys Acta. 2009 Aug;1791(8):797-805.

Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells.
Kawamura H, Tatei K, Nonaka T, Obinata H, Hattori T, Ogawa A, Kazama H, Hamada N, Funayama T, Sakashita T, Kobayashi Y, Nakano T, Izumi T.
J Radiat Res. 2009 Mar;50(2):161-9.

G2A as a receptor for oxidized free fatty acids.
Obinata H, Izumi T.
Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):66-72.

Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation.
Saheki T, Ito H, Sekiguchi A, Nishina A, Sugiyama T, Izumi T, Kojima I.
Cytotechnology. 2008 Jun;57(2):137-43.

CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Izumi T, Yamauchi K, Hisanaga S, Pessin JE, Mori M.
J Biol Chem. 2008 Dec 19;283(51):35455-63.

Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids.
Sasaki Y, Tsujii T, Takeda S, Obinata H, Izumi T, Yamada K, Katakai R.
J Pept Sci. 2008 Dec;14(12):1251-8.

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2.
Konishi A, de Lange T.
Genes Dev. 2008 May 1;22(9):1221-30.

Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I.
Hum Mol Genet. 2008 Jul 1;17(13):1994-2005.

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG Jr.
Nat Cell Biol. 2008 Mar;10(3):361-9.

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr.
Blood. 2008 Mar 15;111(6):3236-44

G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.
Hattori T, Obinata H, Ogawa A, Kishi M, Tatei K, Ishikawa O, Izumi T.
J Invest Dermatol. 2008 May;128(5):1123-33.

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG Jr.
Mol Cell. 2007 Oct 12;28(1):15-27.

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr.
Mol Cell Biol. 2007 Aug;27(15):5381-92.

Purification and characterization of lysophospholipase D from rat brain.
Sugimoto S, Sugimoto H, Aoyama C, Aso C, Mori M, Izumi T.
Biochim Biophys Acta. 2006 Dec;1761(12):1410-8.

Differential induction of cystathionine gamma-lyase in the livers and kidneys of mouse dams during gestation and lactation.
Akahoshi N, Izumi T, Ishizaki Y, Ishii I.
Biol Pharm Bull. 2006 Sep;29(9):1799-802.

5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13).
Koike D, Obinata H, Yamamoto A, Takeda S, Komori H, Nara F, Izumi T, Haga T.
J Biochem. 2006 Mar;139(3):543-9.

ACTH-secreting thymic carcinoid associated with multiple endocrine neoplasia type 1.
Yano M, Fukai I, Kobayashi Y, Mizuno K, Konishi A, Haneda H, Suzuki E, Endo K, Fujii Y.
Ann Thorac Surg. 2006 Jan;81(1):366-8.

Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.
Obinata H, Hattori T, Nakane S, Tatei K, Izumi T.
J Biol Chem. 2005 Dec 9;280(49):40676-83.

Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay.
Endo K, Konishi A, Sasaki H, Takada M, Tanaka H, Okumura M, Kawahara M, Sugiura H, Kuwabara Y, Fukai I, Matsumura A, Yano M, Kobayashi Y, Mizuno K, Haneda H, Suzuki E, Iuchi K, Fujii Y.
Lung Cancer. 2005 Dec;50(3):375-84.

Stress-induced nuclear export of 5-lipoxygenase.
Hanaka H, Shimizu T, Izumi T.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):111-6.

An atypical protein kinase C, PKC zeta, regulates human eosinophil effector functions.
Kato M, Yamaguchi T, Tachibana A, Suzuki M, Izumi T, Maruyama K, Hayashi Y, Kimura H.
Immunology. 2005 Oct;116(2):193-202.

Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.
Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M.
J Biol Chem. 2005 Nov 25;280(47):39246-52.

Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha.
Sugimoto H, Okamura K, Sugimoto S, Satou M, Hattori T, Vance DE, Izumi T.
J Biol Chem. 2005 Dec 9;280(49):40857-66.

EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler.
Sasaki H, Endo K, Konishi A, Takada M, Kawahara M, Iuchi K, Matsumura A, Okumura M, Tanaka H, Kawaguchi T, Shimizu T, Takeuchi H, Yano M, Fukai I, Fujii Y.
Clin Cancer Res. 2005 Apr 15;11(8):2924-9.

Skp2-mediated degradation of p27 regulates progression into mitosis.
Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI.
Dev Cell. 2004 May;6(5):661-72.

Elevated serum epidermal growth factor receptor level in stage IV thymoma.
Sasaki H, Yukiue H, Sekimura A, Mizuno K, Konishi A, Yano M, Fukai I, Fujii Y.
Surg Today. 2004;34(5):477-9.

Endostatin gene transfection using a cationic lipid: advantages of transfection before tumor cell inoculation and repeated transfection.
Yano M, Nakashima Y, Kobayashi Y, Mizuno K, Konishi A, Sasaki H, Fukai I, Scheule RK, Fujii Y.
Cancer Gene Ther. 2004 May;11(5):354-62.

Expression of Smac/DIABLO is a novel prognostic marker in lung cancer.
Sekimura A, Konishi A, Mizuno K, Kobayashi Y, Sasaki H, Yano M, Fukai I, Fujii Y.
Oncol Rep. 2004 Apr;11(4):797-802.

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW.
Nat Cell Biol. 2004 Feb;6(2):121-8.

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.
Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, Matsuoka Y, Zhang L, Yoneda Y, Fujii Y, Skoultchi AI, Tsujimoto Y.
Cell. 2003 Sep 19;114(6):673-88.

Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells.
Obinata H, Yokomizo T, Shimizu T, Izumi T.
Biochem Biophys Res Commun. 2003 Sep 12;309(1):114-9.

Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils.
Suzuki M, Kato M, Hanaka H, Izumi T, Morikawa A.
J Allergy Clin Immunol. 2003 Jul;112(1):126-33.

Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer.
Sasaki H, Yukiue H, Mizuno K, Sekimura A, Konishi A, Yano M, Kaji M, Kiriyama M, Fukai I, Yamakawa Y, Fujii Y.
Int J Clin Oncol. 2003 Apr;8(2):79-82.

Cten mRNA expression was correlated with tumor progression in lung cancers.
Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y.
Lung Cancer. 2003 May;40(2):151-5.

Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation.
Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW.
Oncogene. 2003 Mar 20;22(11):1678-87.

Identification of Ets-1 as an important transcriptional activator of CTP:phosphocholine cytidylyltransferase alpha in COS-7 cells and co-activation with transcriptional enhancer factor-4.
Sugimoto H, Sugimoto S, Tatei K, Obinata H, Bakovic M, Izumi T, Vance DE.
J Biol Chem. 2003 May 30;278(22):19716-22. Epub 2003 Mar 17.

Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4.
Saimura M, Nagai E, Mizumoto K, Maehara N, Minamishima YA, Katano M, Matsumoto K, Nakamura T, Tanaka M.
Clin Cancer Res. 2002 Oct;8(10):3243-9.

Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor.
Takizawa T, Kato M, Kimura H, Suzuki M, Tachibana A, Obinata H, Izumi T, Tokuyama K, Morikawa A.
J Allergy Clin Immunol. 2002 Aug;110(2):241-8.

Leukotriene receptors: classification, gene expression, and signal transduction.
Izumi T, Yokomizo T, Obinata H, Ogasawara H, Shimizu T.
J Biochem. 2002 Jul;132(1):1-6.

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice.
Minamishima YA, Nakayama K, Nakayama K.
Cancer Res. 2002 Feb 15;62(4):995-9.

Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase.
Hanaka H, Shimizu T, Izumi T.
Biochem J. 2002 Feb 1;361(Pt 3):505-14.

Effect of serum depletion on centrosome overduplication and death of human pancreatic cancer cells after exposure to radiation.
Shono M, Sato N, Mizumoto K, Minamishima YA, Nakamura M, Maehara N, Urashima T, Saimura M, Qian L, Nishio S, Nagai E, Tanaka M.
Cancer Lett. 2001 Sep 10;170(1):81-9.

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells.
Sato N, Mizumoto K, Nakamura M, Maehara N, Minamishima YA, Nishio S, Nagai E, Tanaka M.
Cancer Genet Cytogenet. 2001 Apr 1;126(1):13-9.

Down-regulation of p27Kip1 expression is required for development and function of T cells.
Tsukiyama T, Ishida N, Shirane M, Minamishima YA, Hatakeyama S, Kitagawa M, Nakayama K, Nakayama K.
J Immunol. 2001 Jan 1;166(1):304-12.

A possible role for centrosome overduplication in radiation-induced cell death.
Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima YA, Farber JL, Tanaka M.
Oncogene. 2000 Nov 2;19(46):5281-90.

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.
Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K.
Genes Dev. 2000 Jun 15;14(12):1439-47.

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S.
EMBO J. 2000 May 2;19(9):2069-81.

Specificity of Rel-inhibitor interactions in Drosophila embryos.
Tatei K, Levine M.
Mol Cell Biol. 1995 Jul;15(7):3627-34.

Race: a Drosophila homologue of the angiotensin converting enzyme.
Tatei K, Cai H, Ip YT, Levine M.
Mech Dev. 1995 Jun;51(2-3):157-68.

Dif, a dorsal-related gene that mediates an immune response in Drosophila.
Ip YT, Reach M, Engstrom Y, Kadalayil L, Cai H, González-Crespo S, Tatei K, Levine M.
Cell. 1993 Nov 19;75(4):753-63.

New methods to investigate ATP requirement for pre-mRNA splicing: inhibition by hexokinase/glucose or an ATP-binding site blocker.
Tatei K, Kimura K, Ohshima Y.
J Biochem. 1989 Sep;106(3):372-5.

Recognition of 5′ and 3′ splice site sequences in pre-mRNA studied with a filter binding technique.
Tatei K, Takemura K, Tanaka H, Masaki T, Ohshima Y.
J Biol Chem. 1987 Aug 25;262(24):11667-74.

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA.
Mayeda A, Tatei K, Kitayama H, Takemura K, Ohshima Y.
Nucleic Acids Res. 1986 Apr 11;14(7):3045-57.

Messenger RNA splicing: role of small nuclear RNA-protein complexes.
Ohshima Y, Tatei K, Takemura K, Mayeda A, Kitayama H.
Adv Biophys. 1986;21:255-65.

U1 RNA-protein complex preferentially binds to both 5′ and 3′ splice junction sequences in RNA or single-stranded DNA.
Tatei K, Takemura K, Mayeda A, Fujiwara Y, Tanaka H, Ishihama A, Ohshima Y.
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6281-5.

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Professor and Main Research Project

1. Prof. Yoshio Mutoh (1943-1949)
Chemistry, Biochemistry, Mathematics, Physics

2. Prof. Saburo Yamazoe (1949-1974)
Fatigue, Phospholipid of Muscle and Brain, Metabolism in Sperm

3. Prof. Satoshi Yamashita (1974-2000)
Metabolism of Phospholipid, Phospholipase D & C, Choline kinase

4. Prof. Takashi Izumi (2000- )
Lipid mediator, Metabolism of Phospholipid, GPCR