群馬大学 大学院医学系研究科 医学部 医学科

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臨床医学領域 内科学講座

消化器・肝臓内科学

社会に役立つ人事育成と高い水準の基礎研究および臨床研究を行うことは大学の使命であり、私たちは、消化管・肝臓・胆膵領域にわたる研究・診療・教育を一貫して行っています。
基礎研究から臨床研究への橋渡し研究(translational research)の構築・推進を目指し、先進的で実用的な医療の発展に寄与したいと考えています。基礎研究においては、学内の優秀な研究室での研究や海外留学も可能です。臨床研究においては、国際的視野を持ったエビデンスレベルの高い研究を目標とし、関連病院や全国レベルでの多施設共同研究をはじめ国際共同研究の実施も行います。教室員・医会員がお互い協力して、それぞれの課題に取り組んで参ります。

  • スタッフ
  • 研究と教育
  • 臨床業務
  • 社会貢献
  • 業績
  • 沿革

スタッフ

主任教授 浦岡 俊夫
講 師 柿崎  暁
病院講師 河村  修
佐藤  賢
下山 康之
山﨑 勇一
堀口 昇男
助教(臨床研究) 栗林 志行

 

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研究内容

研究内容

・早期消化管癌に対する低侵襲治療法の開発
・革新的な消化管腫瘍に対する内視鏡診断・治療法の開発
・新規内視鏡機器・デバイス・薬剤の開発
・大腸腫瘍の病態解明
・機能性食道疾患の病態解明
・夜間に生じる胃食道逆流の病態生理と薬物の与える影響についての検討
・手術不能かつ内視鏡的切除困難な胃癌に対する光線力学的療法の有効性と安全性の検討
・ウイルス性肝炎の臨床病理学的研究
・非アルコール性脂肪肝炎の病態解明と新規治療法の開発
・遺伝子改変マウスを用いた肝疾患の病態解明
・10mm未満膵嚢胞性病変の多施設前向き研究
・炎症性腸疾患と小胞体ストレスに関する研究

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臨床業務

・消化管早期癌に対する内視鏡的治療(内視鏡的粘膜下層剥離術(ESD)など)
・胃食道逆流症(逆流性食道炎)、アカラシアをはじめとする食道運動障害の診断・治療
・機能性ディスペプシアの診断・治療
・大腸疾患(腫瘍性疾患、炎症性疾患)に関する画像・内視鏡診断、治療
・小腸疾患(腫瘍性疾患、炎症性疾患)に関する画像・内視鏡診断、治療
・内視鏡的逆行性胆膵管造影法(ERCP)手技を応用した、胆膵疾患(膵癌、胆管癌、総胆管結石など)の
 診断および治療
・超音波内視鏡(EUS)手技を応用した、超音波による画像診断やおよび穿刺生検法による病理学的診断を
 含む、胆膵疾患の診断および治療
・自己免疫性膵炎や好酸球性胆管炎など、特殊な胆膵疾患の診断および治療
・胃食道静脈瘤の治療(内視鏡的治療、IVR治療)
・肝細胞癌の内科的治療(ラジオ波焼灼療法、肝動脈塞栓術、重粒子線治療等)
・慢性肝疾患(ウイルス性肝炎、自己免疫性肝炎、非アルコール性脂肪肝炎等)の診断および治療

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社会貢献

・市民公開講座・医療講演会など肝炎・肝がん診療に関する知識の普及・啓発
・肝疾患診療連携病院として県内医療機関の診療ネットワークの構築
・肝炎コーディネータ養成事業など群馬県からの委託業務
・地域拠点病院への胆膵内視鏡医の配置および診療協力体制の構築
・大腸疾患、小腸疾患における県内提携病院等との診療ネットワークの構築
・炎症性腸疾患に関する患者教室

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業績

《2017年》
1. Mehta N, Strong AT, Franco M, Stevens T, Chahal P, Jang S, Lopez R, Patil D, Abe S, Saito Y, Uraoka T, Vargo J, Bhatt A. Optimal injection solution for endoscopic submucosal dissection: A randomized controlled trial of Western solutions in a porcine model. Dig Endosc 2017 [Epub ahead of print]

2. Kinoshita S, Nishizawa T, Uraoka T. Progression to invasive cancer from sessile serrated adenoma/polyp. Dig Endosc. 2017 [Epub ahead of print]

3. Nishizawa T, Akimoto T, Uraoka T, Mitsunaga Y, Maehata T, Ochiai Y, Fujimoto A, Goto O, Kanai T, Yahagi N. Endoscopic string clip suturing method: a prospective pilot study (with video). Gastrointest Endosc 2017 [Epub ahead of print]

4. Kinoshita S, Uraoka T, Nishizawa T, Naganuma M, Iwao Y, Ochiai Y, Fujimoto A, Goto O, Shimoda M, Ogata H, Kanai T, Yahagi N. The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis. Gastrointest Endosc 2017 [Epub ahead of print]

5. Yamada T, Kada A, Uraoka T, Kuwai T, Watanabe N, Sasaki Y, Mabe K, Takahashi Y, Kagaya T, Kimura T, Hamada H, Saito AM, Harada N. Replacement of warfarin with a novel oral anticoagulant in endoscopic mucosal resection: a multicenter, open-label, randomized controlled trial. BMJ Open Gastroenterol 2017;4:e000152

6. Fujimoto A, Uraoka T, Nishizawa T, Shimoda M, Goto O, Ochiai Y, Maehata T, Akimoto T, Mitsunaga Y, Sasaki M, Yamamoto H, Yahagi N. Rebamipide solution: a novel submucosal injection material to promote healing speed and healing quality of ulcers induced by endoscopic submucosal dissection. Gastrointest Endosc 2017 [Epub ahead of print]

7. Banno S, Nishizawa T, Kinoshita S, Mori H, Uraoka T. Endoscopic mucosa-submucosal clip closure method. Endoscopy 2017;49:E307-8

8. Banno S, Kato M, Sunata Y, Hirai Y, Kubosawa Y, Abe K, Takada Y, Hirata T, Takatori Y, Wada M, Kinoshita S, Mori H, Takabayashi K, Kikuchi M, Uraoka T. Risk Factor for Vital Signs Fluctuation during Colonoscopy under Conscious Sedation Consisting of Midazolam and Meperidine. Dig Dis. 2017 [Epub ahead of print]

9. Basford P, Longcroft-Wheaton G, Higashi R, Uraoka T, Bhandari P. Colonic lesion characterisation skills among UK endoscopists and the impact of a brief training intervention. Frontline Gastroenterol 2017;8:2-7

10. Yahagi N, Nishizawa T, Sasaki M, Ochiai Y, Uraoka T. Water pressure method for duodenal endoscopic submucosal dissection. Endoscopy 2017;49:E227-8

11. Wada M, Kato M, Hirai Y, Uraoka T. Salvage resection of recurrent polyp after polypectomy on the colorectal anastomosis using endoscopic submucosal dissection. Gastrointest Endosc 2017;85:1305-6

12. Oka S, Uraoka T, Tamai N, Ikematsu H, Chino A, Okamoto K, Takeuchi Y, Imai K, Ohata K, Shiga H, Raftopoulos S, Lee BI, Matsuda T. Standardization of endoscopic resection for colorectal tumors larger than 10 mm in diameter. Dig Endosc 2017r;29 Suppl 2:40-4

13. Kato M, Shiraishi J, Uraoka T. Second local recurrence with advanced rectal cancer after salvage endoscopic mucosal resection of local recurrence following initial cold polypectomy. Dig Endosc. 2017;29:636

14. Fujimoto A, Goto O, Nishizawa T, Ochiai Y, Horii J, Maehata T, Akimoto T, Kinoshita S, Sagara S, Sasaki M, Uraoka T, Yahagi N. Gastric ESD may be useful as accurate staging and decision of future therapeutic strategy. Endosc Int Open 2017;5:E90-5

15. Naganuma M, Yahagi N, Bessho R, Ohno K, Arai M, Mutaguchi M, Mizuno S, Fujimoto A, Uraoka T, Shimoda M, Hosoe N, Ogata H, Kanai T. Evaluation of the severity of ulcerative colitis using endoscopic dual red imaging targeting deep vessels. Endosc Int Open 2017;5:E76-82

16. Nishizawa T, Ochiai Y, Uraoka T, Akimoto T, Mitsunaga Y, Goto O, Fujimoto A, Maehata T, Kanai T, Yahagi N. Endoscopic slip-knot clip suturing method: prospective pilot study (with video). Gastrointest Endosc 2017;85:433-7

17.    Kinoshita S, Nishizawa T, Ochiai Y, Uraoka T, Akimoto T, Fujimoto A, Maehata T, Goto O, Kanai T, Yahagi N. Accuracy of biopsy for the preoperative diagnosis of superficial nonampullary duodenal adenocarcinoma. Gastrointest Endosc 2017;86:329-32

18.    Kawada A, Kusano M, Hosaka H, Kuribayashi S, Shimoyama Y, Kawamura O, Akiyama J, Yamada M and Akuzawa M, Increase of transient lower esophageal sphincter relaxation associated with cascade stomach. J Cin Biochem Nutr 2017;60:211-215

19.    Shimoyama Y, Thyroid hormones and their related disease Thyroid hormone and digestive system. Journal of the Japan Thyroid Association 2017;8:231-240

20.    Shimoyama Y, Kuribayashi S, Hosaka H, Kawamura O, Fukai Y, Nakayama T, Tanaka H, Tomizawa T, Hoshi K, Yamada T, Mizuide M, Kakizaki S and Kusano M. Chapter5. Photodynamic Therapy for Gastric Cancer Patients on Oral Antithrombotic Therapy. Photodynamic Therapy (PDT): Principles, Mechanisms and Applications 2017;171-184

21.    Shimoyama Y, Kuribayashi S, Hosaka H, Kakizaki S, Kawamura O and Kusano M. A Case of Undifferentiated rectal carcinoma revealed by autopsy. SMGroup Gastrointestinal Endoscopy 2017;3:1-6

22.    Hatanaka T, Arai H, Shibasaki M, Tojima H, Takizawa D, Toyoda M, Takayama H, Abe T, Sato K, Kakizaki S, Yamada M. Factors predicting overall response and overall survival in hepatocellular carcinoma patients undergoing balloon-occluded transcatheter arterial chemoembolization: A retrospective cohort study. Hepatol Res 2017;5 [Epub ahead of print].

23.    Toyoda H, Chayama K, Suzuki F, Sato K, Atarashi T, Watanabe T, Atsukawa M, Naganuma A, Notsumata K, Osaki Y, Nakamuta M, Takaguchi K, Saito S, Kato K, Pugatch D, Burroughs M, Redman R, Alves K, Pilot-Matias TJ, Oberoi RK, Fu B, Kumada H.Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection. Hepatology 2017;9 [Epub ahead of print]

24.    Sato K, Naganuma A, Nagashima T, Hoshino T, Uehara D, Arai Y, Horiuchi K, Yuasa K, Takayama H, Arai H, Hatanaka T, Ohyama T, Tahara H, Sohara N, Kobayashi T, Horiguchi N, Yamazaki Y, Kakizaki S, Kusano M, Yamada M, Murase T, Nakamura T. Elevated serum uric acid level was a notable adverse event during combination therapy with sofosbuvir and ribavirin. Hepatol Res. 2017;8 [Epub ahead of print]

25.    Chan WK, Treeprasertsuk S,  Imajo K, Nakajima A, Seki Y, Kasama K, Kakizaki S, Fan JG, Song MJ, Yoon SK, Dan YY, Lesmana LA, Ho KY, Goh KL, Wong VWS. Clinical features and treatment of non-alcoholic fatty liver disease across the Asia Pacific region – the GO ASIA initiative. Aliment Pharm Ther. 2017, in press.

26.    Shiba S, Abe T, Shibuya K, Katoh H, Koyama Y, Shimada H, Kakizaki S, Shirabe K, Kuwano H, Ohno T, Nakano T. Carbon ion radiotherapy for 80 years or older patients with hepatocellular carcinoma. BMC Cancer. 2017;17:721

27.    Yamasaki Y, Kobayashi K, Inaba A, Uehara D, Tojima H, Kakizaki S, Chiba K. Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice. Xenobiotica. 2017;11:1-8. [Epub ahead of print]

28.    Yamazaki Y, Naganuma A, Arai Y, Takeuchi S, Kobayashi T, Takakusagi S, Hatanaka T, Hoshino T, Namikawa M, Hashizume H, Takizawa D, Ohyama T, Suzuki H, Horiguchi N, Takagi H, Sato K, Kakizaki S, Kusano M, Nagashima S, Takahashi M, Okamoto H, Yamada M. Clinical and virological features of acute hepatitis E in Gunma prefecture, Japan between 2004 and 2015. Hepatol Res. 2017;47:435-445.

29.    Yamabe A, Irisawa A, Shibukawa G, Sato A, Fujisawa M, Arakawa N, Yoshida Y, Igarashi R, Maki T, Yamamoto S, Ikeda T, Abe Y, Hoshi K. Inflammatory Bile Duct Obstruction during the Healing Stage of Severe Acute Pancreatitis. Intern Med .2017;56:1037-1040

30.    Sato A, Irisawa A, Bhutani MS, Shibukawa G, Yamabe A, Fujisawa M, Igarashi R, Arakawa N, Yoshida Y, Abe Y, Maki T, Hoshi K, Ohira H. Significance of normal appearance on endoscopic ultrasonography in the diagnosis of early chronic pancreatitis. Endosc Ultrasound 2017;10

《2016年》
1.    Nishizawa T, Uraoka T, Sagara S, Suzuki H, Akimoto T, Kanai T, Yahagi N.  Endoscopic slipknot clip suturing method: an ex vivo feasibility study (with video).  Gastrointest Endosc 2016;83:447-50

2.    Schölvinck DW, Goto O, Seldenrijk CA, Bisschops R, Horii J, Ochiai Y, Schoon EJ, Schenk BE, Uraoka T, van Oijen MG, Bergman JJ, Yahagi N, Weusten BL. Detection of palisade vessels as a landmark for Barrett’s esophagus in a Western population. J Gastroentero 2016;51:682-90

3.    Hayward C, Uraoka T, Yahagi N. Endoscopic submucosal dissection and its potential role in the management of early colorectal neoplasia in UK. Frontline Gastroenterol 2016;7:129-34

4.    Sano Y, Tanaka S, Kudo SE, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K, Horimatsu T, Sakamoto N, Fu KI, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I, Terai T, Yamano HO, Kaneko K, Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Iwatate M, Ishikawa H, Murakami Y, Yoshida S, Saito Y. Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team. Dig Endosc 2016;28:526-33

5.    Matsuda T, Oka S, Ikematsu H, Matsushita HO, Mori Y, Takeuchi Y, Tamai N, Kawamura T, Chino A, Keum B, Khomvilai S, Uraoka T. Endoscopic diagnosis of colorectal serrated lesions: Current status and future perspectives based on the results of a questionnaire survey. Dig Endosc 2016;28 Suppl 1:35-42

6.    Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, Ohta Y, Toshimitsu K, Nakazato Y, Kawasaki K, Uraoka T, Watanabe T, Kanai T, Sato T.  A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell 2016;18:827-38

7.    Pioche M, Rivory J, Nishizawa T, Uraoka T, Touzet S, O’Brien M, Saurin JC, Ponchon T, Denis A, Yahagi N  Randomized comparative evaluation of endoscopic submucosal dissection self-learning software in France and Japan. Endoscopy 2016;48:1076-83

8.    Kusano M, Hosaka H, Yasuoka H, Kawamura O, Kawada A, Kuribayashi S, Shimoyama Y, Mizuide M, Tomizawa T, Ishihara S, Sagawa H, Akiyama J, Sato K, Kakizaki S, Moki F New endoscopic classification of cascade stomach, a risk factor for reflux esophagitis. J Gastroenterol 2016;52:211-217

9.    Kawamura O, Kohata Y, Kawami N, Iida H, Kawada A, Hosaka H, Shimoyama Y, Kuribayashi S, Fujiwara Y, Iwakiri K, Inamori M, Kusano M, Hongo M. Liquid-containing and acid refluxes may be less frequent in the Japanese population -Normal values of 24-hour esophageal impedance and pH monitoring. J Neurogastroenterol Motil 2016;22:620-629

10.    Iwakiri K, Kinoshita, Habu Y, Oshima T, Manabe N, Fujiwara Y, Nagahara A, Kawamura O, Iwakiri R, Ozawa S, Ashida K, Ohara S, Kashiwagi H, Adachi K, Higuchi K, Miwa H, Fujimoto K, Kusano M, Hoshihara Y, Kawano T, Haruma K, Hongo M, Sugano K, Watanabe M, Shimosegawa T. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol 2016;51:751-67

11.    Narita T, Yunoki S, Ohyabu Y, Yahagi N, Uraoka T. In situ gelation properties of a collagen-genipin sol with a potential for the treatment of gastrointestinal ulcers. Med Devices (Auckl) 2016;9:429-39

12.    Uraoka T, Ochiai Y, Fujimoto A, Goto O, Kawahara Y, Kobayashi N, Kanai T, Matsuda S, Kitagawa Y, Yahagi N. A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection─induced ulcer in the stomach. Gastrointest Endosc 2016;83:1259-64

13.    Niikura R, Nagata N, Doyama H, Ota R, Ishii N, Mabe K, Nishida T, Hikichi T, Sumiyama K, Nishikawa J, Uraoka T, Kiyotoki S, Fujishiro M, Koike K. Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan: A multicenter questionnaire study. World J Gastrointest Endosc 2016;8:785-94

14.    Takatori Y, Kato M, Sakaguchi E, Banno S, Abe K, Takada Y, Hirata T, Wada M, Kinoshita S, Takabayashi K, Kikuchi M, Kikuchi M, Fujiyama Y, Uraoka T.  A case of extra-medullary involvement of acute monocytic leukemia that presented as obstructive jaundice.  Gastrointest Endosc 2016;83:666-7

15.    Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M.  Large muscle layer defect of stomach caused by ESD closed by using the endoloop-clips technique. Gastrointest Endosc 2016;83:1282-3

16.    Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M. Laterally spreading tumor involving a colon diverticulum successfully resected by endoscopic submucosal dissection. Gastrointest Endosc 2016;84:191-2

17.    Seki Y, Kakizaki S, Horiguchi N, Hashizume H, Tojima H, Yamazaki Y, Sato K, Kusano M, Yamada M, Kasama K. Prevalence of nonalcoholic steatohepatitis in Japanese patients with morbid obesity undergoing bariatric surgery. J Gastroenterol. 2016;51:281-9

18.    Hatanaka T, Kakizaki S, Shimada Y, Takizawa D, Katakai K, Yamazaki Y, Sato K, Kusano M, Yamada M. Early decreases in α-fetoprotein and des-γ-carboxy prothrombin predict the antitumor effects of hepatic transarterial infusion chemotherapy with CDDP powder in patients with advanced hepatocellular carcinoma. Intern Med. 2016;55:2163-71

19.    Sagawa T, Kakizaki S, Tomizawa T, Nakayama T, Tanaka H, Tojima H, Sato K, Kusano M, Okamura S, Yamada M. Faecal lactoferrin is a useful biomarker for mucosal healing in patients with ulcerative colitis during granulocyte and monocyte adsorptive apheresis therapy. Colorectal Dis. 2016;18:696-702.

20.    Koki Hoshi, Atsushi Irisawa, Goro Shibukawa, Akane Yamabe, Mariko Fujisawa, Ryo Igarashi, Ai Sato, Takumi Maki. Agenesis of the gallbladder in monozygotic twin sisters. Case Reports in Gastrointest Med 2016

21.    Koki Hoshi, Atsushi Irisawa, Goro Shibukawa, Akane Yamabe, Mariko Fujisawa, Ryo Igarashi, Yoshitsugu Yoshida, Yoko Abe, Koh Imbe. Validation of a realistic, simple, and inexpensive EUS-FNA training model using isolated porcine stomach. Endoscopy International Open 2016:E1004-E1008

22.    Mukai S, Itoi T, Ashida R, Tsuchiya T, Ikeuchi N, Kamada K, Tanaka R, Umeda J, Tonozuka R, Fukutake N, Hoshi K, Moriyasu F, Gotoda T, Irisawa A. Multicenter, prospective, crossover trial comparing the door-knocking method with the conventional method for EUS-FNA of solid pancreatic masses (with videos). Gastrointest Endosc 2016;1210-7

23.    Akane Yamabe, Atsushi Irisawa, Goro Shibukawa, Koki Hoshi, Mariko Fujisawa, Ryo Igarashi, Yoko Abe, Koh Imbe. An experimental study to assess the best maneuver when using a reverse side-bevel histology needle for EUS-guided fine-needle biopsy. Endosc Int Open 2016;E56-61

24.    Yamabe A, Irisawa A, Wada I, Shibukawa G, Fujisawa M, Sato A, Igarashi R, Maki T, Hoshi K. Application of a silver coating on plastic biliary stents to prevent biofilm formation : an experimental study using electron microscopy. Endosc Int Open 2016;E1090-E1095

25.    Yamabe A, Irisawa A, Shibukawa G, Hoshi K, Fujisawa M, Igarashi R, Sato A, Maki T, Hojo H. Rare condition of needle tract seeding after EUS-guided FNA for intraductal papillary mucinous carcinoma. Endosc Int Open 2016;E756-8

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沿革

私たちはこれまで旧第一内科学の第三研究室として活動してきましたが、平成29年度になり消化器・肝臓内科学の講座として新しくスタートし、平成30年1月に初代教授として浦岡俊夫教授が着任しました。これまでの伝統を継承しつつ諸先輩方のご指導を賜りながら、多方面で活躍する消化器・肝臓内科医および研究者の育成に努めます。