1. 重粒子線治療の基礎的，臨床的研究
2. 放射線感受性に関与する腫瘍関連遺伝子，細胞増殖因子受容体およびそのシグナル伝達に関する研究
3. 放射線誘発アポトーシスとp53その他癌関連遺伝子に関する研究
4. 低酸素細胞マーカーによる組織内低酸素細胞と放射線に関する研究
5. 悪性腫瘍の診断，治療におけるFDG-PETの有用性の研究
6. 前立腺癌，子宮頸癌，肺癌，悪性リンパ腫の放射線治療に関する研究

医学部教育；
放射線生物学および放射線治療についての講義，実習を行ない，医師に必要な放射線腫瘍学の基礎知識を習得させている．

大学院教育：
古典的な放射線生物学，放射線治療学から，分子生物学や病理学，その他も含めた腫瘍学全般について幅広く教育を行ない，放射線腫瘍学分野の研究者および専門的な臨床腫瘍医を育成している．特に重粒子線治療の高度に関する先端的研究を推進する。

1. 放射線治療；年間900人以上の放射線治療を行っている（脳腫瘍，頭頸部癌，肺癌，乳癌，食道癌，前立腺癌，子宮癌，リンパ腫等）：直線加速器3台による外照射，低線量率・高低線量率小線源治療（腔内照射，組織内照射），放射性ヨードによる甲状腺治療疾患の治療等．
2. 重粒子線治療；2010年3月より開始しており、頭頸部癌，肺癌，肝臓癌，前立腺癌，骨軟部腫瘍などの治療を行なっている．2010年度は92例の治療を行ない，2011年度はさらに200例程度の治療を行う予定である．
3. 病棟診療；放射線治療の他，化学療法，緩和医療も行なっている．
4. 悪性腫瘍患者の診断；X線，CT，MRI，超音波，PET等の画像，内視鏡を用いた診断および治療方針の決定を行なっている．

1. IAEA（国際原子力機関）の活動への協力：　ワークショップを定期的に開催し，さらに平成１5年度からは教授が国際原子力機関（IAEA）のアジア地域活動の医療・健康分野の責任者を努めている．
2. 重粒子線治療の普及に努め，研究会や講演会を開催している．
3. Austral-Asian Journal of Cancerの事務局として癌研究の発展に貢献している．
4. 群馬放射線腫瘍研究会事務局として，地域の放射線腫瘍学，癌治療の発展に貢献している．

Al-Jahdari WS, Sakurai H, Yoshida Y, Mobaraki A, Suzuki Y, Nakano T.
MK615, a prospective anti-proliferative agent, enhances CD4/CD8 ratio after exposure to irradiation. 
Int J Radiat Oncol Biol Phys. 87:81-90, 2011.

Wakatsuki M, Ohono T, Yoshida D, Noda S, Saitoh J, Shibuya K, Katoh H, Suzuki Y, Takahashi T,Nakano T.
Intracavitary Combined with CT-guided Interstitial Brachytherapy for Locally Advanced Uterine Cervical Cancer: Introduction of the Technique and a Case Presentation.
J Radiat Res. 52:54-58, 2011

Yoshida D, Ebara T, Sato Y, Kaminuma T, Takahashi T, Asao T, Nakano T.
Interaction of radiation and pemetrexed on a human malignant mesothelioma cell line in vitro.
Anticancer Res. 31:2847-51, 2011

Ohkubo Y, Kato S, Kiyohara H, Tsuruoka I, Tamaki T, Noda SE, Ohno T, Nakano T.
Dose volume analysis of radiotherapy for inoperable patients with stage I-II endometrial carcinoma.
J Radiat Res. 52:666-73, 2011

Fukuoka K, Tanaka F, Tsujimura T, Hashimoto-Tamaoki T, Hasegawa S, Nakano T.
Exploratory study on the detection of markers for diagnosing early-stage malignant mesothelioma.
Nihon Eiseigaku Zasshi. 66:553-7, 2011

Tamaki T, Ishikawa H, Takahashi T, Tamaki Y, Kitamoto Y, Okamoto M, Noda SE, Katoh H, Shirai K, Sakurai H, Nakano T.
Comparison of efficacy and safety of low-dose-rate vs. high-dose-rate intraluminal brachytherapy boost in patients with superficial esophageal cancer.
Brachytherapy. 2011 Jun 21. [Epub ahead of print]

Yamada S, Tabata C, Tabata R, Fukuoka K, Nakano T.
Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma.
Clin Chem Lab Med. 49:1721-6, 2011

Okamoto M, Ishikawa H, Ebara T, Kato H, Tamaki T, Akimoto T, Ito K, Miyakubo M, Yamamoto T, Suzuki K, Takahashi T, Nakano T.
Rectal Bleeding After High-Dose-Rate Brachytherapy Combined with Hypofractionated External-Beam Radiotherapy for Localized Prostate Cancer: The Relationship Between Dose-Volume Histogram Parameters and the Occurrence Rate.
Int J Radiat Oncol Biol Phys. 2011 May 26. [Epub ahead of print]

Toita T, Kato S, Niibe Y, Ohno T, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Tokumaru S, Yamauchi C, Suzuki O, Sakurai H, Numasaki H, Teshima T, Oguchi M, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N.
Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2).
Int J Radiat Oncol Biol Phys. 2011 Apr 4. [Epub ahead of print]

Shirai K, Tamaki Y, Kitamoto Y, Takahashi T, Ishikawa H, Nonaka T, Murata K, Satoh Y, Higuchi K, Nakano T.
Comparison of chemoradiotherapy with radiotherapy alone in patients with esophageal adenocarcinoma.
J Radiat Res. 52:264-9, 2011

Shirai K, Suzuki Y, Okamoto M, Wakatsuki M, Noda SE, Takahashi T,Ishiuchi S.Hasegawa M, Nakazato Y, Nakano T.
Influence ofhistological subtype on survival after combined therapy of surgery and radiation in WHO grade 3 glioma. 
J Radiat Res. 51:589-94, 2010

Kaminuma T, Suzuki Y, Shirai K, Mizui T, Noda SE, Yoshida Y, Funayama T, Takashi T, Kobayashi Y, Shirao T, Nakano T.
Effectiveness of carbon-ion Beams for Apoptosis Induction in Rat Primary Immature Hippocampal Neurons. 
J Radiat Res. 51:627-631, 2010.

Kaminuma T, Karasawa K, Hanyu N, Chang TC, Kuga G, Okano N, Kubo N, Okuma Y, Nagata Y, Maeda Y, Ajisawa A.
Acute Adverse Effect of Radiation therapy on HIV-positive patients in Japan: Study of 31 cases of Tokyo Metoropolitan Komagome hospital. 
J Radiat Res. 51:749-753, 2010.

Ohkubo Y, Iwakawa M, Seino K, Nakawatari M, Wada H, Kamijuku H, Nakamura E, Nakano T, Imai T.
Combining Carbon Ion Radiotherapy and Local Injection of α-Galactosylceramide-Pulsed Dendritic Cells Inhibits Lung Metastases in an In Vivo Murine Model. 
Int J Radiat Oncol Biol Phys. 78:1524-31, 2010.

Oike T, Ohno T, Wakatsuki M, Noda SE, Saitoh JI, Mizukami T, Yoshimoto Y, Okonogi N, Katoh H, Shibuya K, Suzuki Y, Ishikawa H, Ebara T, Takahashi T, Nakano T.
The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Iliac Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer: A Dosimetric Study. 
Journal of Radiation Research. 51:715-21, 2010.

Ishikawa H, Nonaka T, Sakurai H, Tamaki Y, Kitamoto Y, Ebara T, Shioya M, Noda SE, Shirai K, Suzuki Y, Takahashi T, Nakano T.
Usefulness of intraluminal brachytherapy combined with external beam radiation therapy for submucosal esophageal cancer: long-term follow-up results. 
Int J Radiat Oncol Biol Phys. 76:452-9, 2010.

Japan Clinical Oncology Group, Toita T, Ohno T, Kaneyasu Y, Uno T, Yoshimura R, Kodaira T, Furutani K, Kasuya G, Ishikura S, Kamura T, Hiraoka M.
A Consensus-based Guideline Defining the Clinical Target Volume for Pelvic Lymph Nodes in External Beam Radiotherapy for Uterine Cervical Cancer. 
Jpn J Clin Oncol. 40(5):456-63, 2010.

Nakano T, Ohno T, Ishikawa H, Suzuki Y, Takahashi T.
Current Advancement in Radiation Therapy for Uterine Cervical Cancer. 
J.Radiat.Res. 51:1-8, 2010.

Takahashi T, Fukawa T, Hirayama R, Yoshida Y, Musha A, Furusawa Y, Ando K, Nakano T.
In vitro interaction of high-LET heavy-ion irradiation and chemotherapeutic agents in two cell lines with different radiosensitivities and different p53 status. 
Anticancer Res. 30:1961-7, 2010.

Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Nonaka T, Ishikawa H, Katoh H, Takahashi T, Nakano T.
Dose-Volume Histogram Parameters and Clinical Factors Associated with Pleural Effusion After Chemoradiotherapy in Esophageal Cancer Patients. 
Int J Radiat Oncol Biol Phys. in press, 2010.

Mobaraki A, Ohno T, Yamada S, Sakurai H, Nakano T.
Cost-effectiveness of carbon ion radiation therapy for locally recurrent rectal cancer. 
Cancer Sci. 101:1834-9, 2010.

Suzuki Y, Shirai K, Oka K, Mobaraki A, Yoshida Y, Noda SE, Okamoto M, Suzuki Y, Itoh J, Itoh H, Ishiuchi S, Nakano T.
Higher pAkt expression predicts a significant worse prognosis in glioblastomas. 
J Radiat Res. 51:343-8, 2010.

Kato S, Tran DN, Ohno T, Nakano T, Kiyohara H, Ohkubo Y, Kamada T.
CT-based 3D dose-volume parameter of the rectum and late rectal complication in patients with cervical cancer treated with high-dose-rate intracavitary brachytherapy. 
J Radiat Res. 51:215-21, 2010.

Katoh H, Ishikawa H, Hasegawa M, Yoshida Y, Suzuki Y, Ohno T, Takahashi T, Nakano T.
Protective effect of urinary trypsin inhibitor on the development of radiation-induced lung fibrosis in mice.
J Radiat Res. 51:325-32, 2010.